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199,248 grants found
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Receptor-mediated mechanisms in Parkinson´s disease and depression
This programme aims at providing better biomarkers anbd mechanism-based therapies for two common diseases: Parkinson´s disease (PD) and Major depressive disorder (MDD). Besides mot...
Mechanisms of antiviral defense in the CNS - uncovered through patient-mimicking transgenic mice and human brain organoids
Viral infections can cause devastating diseases if not controlled by the immune system.This includes diseases in the central nervous system (CNS) where e.g. herpes simplex virus 2...
Building Bone: Harnessing Fetal Mesenchymal Stem Cells to Treat Osteogenesis Imperfecta.
Our aim is to harness the full potential of our recently developed fetal mesenchymal stem cell (fMSC) therapy.We are currently about to change the lives of people living with Osteo...
The significance of environmental and lifestyle factors for the onset and course of multiple sclerosis.
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults in Europe. The etiology is unclear. Twin studies suggest that environment and/...
BEAM-MS - Brain-resident cell Epigenetics Altered by the Metabolome to target Multiple Sclerosis
Multiple Sclerosis (MS) is a major neurological disorder, characterized by the loss of myelin around nerve axons in the central nervous system due to autoimmune attacks.Oligodendro...
To find the cause of rheumatoid arthritis using humanized mouse models with the major polymorphic genes; HLA-DR and NCF1
Purpose and objective: Investigate the cause of rheumatoid arthritis (RA) using unique mouse strains expressing the major disease-associated human alleles (DRB1 and NCF1) to develo...
IL-6 trans-signalling in HPS and HFRS pathogenesis: a treatable target?
Hantaviruses cause two severe acute diseases; hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal syndrome (HFRS). Fatality rates are 35-40% for HPS and up to 10%...
Pathogenic mechanisms and effects of treatment in chronic, idiopathic inflammatory myopathies, myositis
Myositis is a complex autoimmune disease with high morbidity and mortality. Biomarkers to predict prognosis are lacking.Newly discovered myositis specific autoantibodies predict di...
Understanding how MYC drives transcriptional amplification via regulation of DNA topology
Inhibitors of Topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy. While they have proven effective, the toxicity of current TOP drugs in non-cancer cells, limits...
Towards personalized medicine in pregnancy: Early prediction of pregnancy complications to improve maternal and fetal outcomes
Purpose.The existing antenatal care program is similar for most women with increasing frequency of visits as the pregnancy progresses, aiming to find established pregnancy complica...
Unravelling the Molecular Signatures of Reproductive Mood Disorders: a Multi-Omics Approach Project
The MoodMAP project targets the challenge of diagnosing and treating reproductive mood disorders (RMDs), such as premenstrual disorder and postpartum depression, which significantl...
´Stronger Together´ - Psychological support for parents of children diagnosed with cancer
Parents of children with cancer report increased levels of psychological and relationship distress.Yet, there is a lack of interventions in paediatric oncology care addressing thes...
Platform development of engineered extracellular vesicles for gene editing in the CNS
To date, there are no curative treatments for most neurodegenerative disorders, including synucleinopathies of the central nervous system (CNS) such as Parkinsons disease (PD).The...
Impact of Collective Chemical Exposome of Infertile Couples on the Likelihood of Clinical Pregnancy and Live Birth
Infertility affects 15-20% of all couples during their reproductive lifespans and is a significant couple and public health problem.Despite advanced techniques to address infertili...
Environment before adulthood in Multiple Sclerosis etiology
Through Swedish multiple sclerosis (MS) registers and microbiological biobanks crosslink, we have formed the world´s largest material with pre-symptomatically drawn serum samples....
Regulation of nuclear processes by mast cell tryptase - molecular mechanisms and disease implications
Mast cells (MCs) are versatile immune cells mostly known for their detrimental actions in allergic disease, but they have also been implicated in a range of other pathological sett...
Defining persisting brain injury after eclampsia and identifying new treatment targets to protect the maternal brain
The goal of this project is to define neurological outcomes after eclampsia and to determine underlying pathophysiological pathways to eclampsia which will lead to new drugs for ne...
Medication-wide surveillance of pregnancy drug safety in large-scale real-world data: systematic generation of missing evidence to inform clinical decision-making
Most prescription drugs lack enough evidence on their safety for use during pregnancy.Our overall aim is to systematically gather new evidence for the safety of a comprehensive ran...
A Comprehensive Molecular Map of Human Ovaries Across Life Stages for the Development of Novel Fertility and Ovarian Reserve Markers
Human fertility rates have declined below the population replacement rate in every EU member state, with the age of first-time mothers increasing to 30-years.Maternal age significa...
Is being overweight early in life a risk factor for early diagnosis of type 1 diabetes in children and, if so, does it explain the increase in T1D incidence during the Covid pandemic?
Type 1 diabetes (T1D) is one of the most common disease among children in Sweden and the incidence has doubled in recent decades. Numerous studies have reported an even higher inci...