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199,248 grants found
Showing 6,641 – 6,660 of 199,248 grants
Genetics Of Rare Polygenic Interstitial Lung Disease
The Interstitial Lung Diseases (ILDs) are a group of rare diseases characterised by inflammation and scarring in the lungs. ILDs can occur as a consequence of inhalation of specifi...
Lineage and ecomorphological diversification of burrowing snakes
Snakes are a large radiation (ca. 4,000 species) of reptiles that evolved from lizard ancestors.Although the early evolutionary history of snakes is hotly debated, the remarkable t...
C9orf72 associated motor neurone disease (MND):investigating the genetic penetrance, expressivity, metabolic and inflammatory clinic-ready biomarkers
The hexanucleotide intronic expansion in C9orf72 is the most common Mendelian cause of MND, but we still have limited understanding of the disease penetrance, expressivity of sever...
Youth wellbeing, healthy relationships and GBV prevention in Tanzania
This participatory action research project will work with young people aged 18-25 in Dar es Salaam, Tanzania to explore the links between emotional wellbeing, relationship quality...
DYNAREP: Illuminating the dynamics of eukaryotic replication on DNA and chromatin
The copying of DNA, or DNA replication, is essential to cellular function. In eukaryotes it is carried out with high fidelity by a multiprotein complex called the replisome. Failur...
Investigating Novel Functions of DCAF16 and unveiling its Degron Sequence for the development of novel drugs (DEGRON)
Targeted therapies are designed to attack specific molecules that are involved in cancer growth and spread.In recent years, targeted therapies have made significant progress in tre...
QUIQ: Quantum information processed at attosecond timescale in double quantum-dot qubits
In the realm of quantum information technology (QIT), scalable qubit platforms with long coherence times and high-fidelity gates areessential for achieving quantum computational po...
Understanding and Improving Electrochemical Carbon Dioxide Capture
This transformative research fellowship will advance electrochemical carbon dioxide capture as a greenhouse gas mitigation technology.To limit global warming to 1.5C and avoid cata...
FLF extension proposal: Re-envisioning child mental health promotion interventions with digital technology
The aims of the fellowship are to examine how emerging technologies can fundamentally re-envision the conceptual models and mechanisms-of-delivery for existing prevention intervent...
Using a novel STAC3 mouse model to bridge the gap in myopathy and malignant hyperthermia mechanisms
A number of hereditary muscle disorders cause muscle weakness coupled with susceptibility to malignant hyperthermia (MH), a potentially fatal reaction to the most commonly used gen...
TopROCS: Topologically protected chiral sensing
Chiral molecules of opposite handedness are indistinguishable when they interact with a mirror-symmetric object, but havedramatically different responses when they interact with an...
The META Trial
Diabetes is a common co-morbidity among people living with HIV. Since Oct 2021, we have been conducting a phase IIIrandomised placebo-controlled trial of metformin among people liv...
UnderstandiNg fraIlty tOwards a future of healthy ageiNg
With falling birth rates and increasing life expectancy we are an ageing society. 20% of boys and 25% of girls born in 2019 are expected to reach their 100th birthday. This would b...
Verifiable and safe multi-agent reinforcement learning
The research proposed here aims to enhance and further investigate safe reinforcement learning in the multi-agent context. To deliver on the objectives in question, it will require...
HELP-GT_Small RNA adjuvants for efficient cardiac gene therapy and gene editing
Progress in gene therapy has been remarkable over the last decade. While most of the in vivo applications are based on the adenoassociated virus (AAV), broader use of these vectors...
Developing an in silico model of the cutaneous lipidome to explore the molecular mechanisms of developing dry skin
Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils.For information on current funding routes, see the common terminology at https:/...
Controlling the formation and properties of topological magnetic phenomena
Throwing a stone into water excites a wave that decays in distance and time. However, some wave-like phenomena, known as topological objects (TOs), don't behave like this. The...
The Ecology of Animal Cognition
ECOLLIGENCE seeks to change the way we think about the evolution of animal memory.For almost fifty years, the field of cognitive ecology has striven to identify ecological selectio...
POWER: Printed Circuit Board Optimized Water Electrolysis with Reduced PGM
To reach Net Zero greenhouse gas (GHG) emissions green hydrogen is needed, particularly for hard-to-abate sectors such as heavy industry, aviation etc.. The majority of green hydro...
MARS: Minimizing Antibiotic-induced Resistant Superinfections
Antibiotics have transformed medicine, saving millions of lives since they were first used to treat a bacterial infection over 80-years ago. But the use of antibiotics also comes w...