Results for Technology
53,864 grants found
Showing 49,741 – 49,760 of 53,864 grants for "Technology"
Mechanisms and effects of pallidal deep brain stimulation on levodopa resistant motor signs in Parkinson's disease
Project Summary/Abstract A large percentage of people with Parkinson’s disease (PD) will develop debilitating levodopa-resistant impairment in postural stability and gait disturban...
Flipped Germinal Centers
PROJECT SUMMARY Developing universal vaccines to influenza and HIV-1 is an urgent global goal. A critical challenge is that immune responses to native HIV-1 envelope (Env) and infl...
Treatment and prevention of osteoarthritis with an intra-articular disease-modifying regenerative therapy
Abstract Nearly one in every ten Americans, and one in every three over the age of 65-years, suffers from osteoarthritis (OA), a degenerative joint disorder that causes progressive...
Ultrasound-based sensors for the fusion and motion correction of MRI and PET/CT data
Project summary Radiology departments are equipped with many different types of medical imaging scanners, such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PE...
Constrained Disentanglement (CODE) Network for CT Metal Artifact Reduction in Radiation Therapy
?ABSTRACT The World Health Organization reported that cancer is the second leading cause of death globally and is re- sponsible for 9.6 million deaths in 2018. Approximately 50% of...
Small molecule inhibitors of hyperphosphorylated tau aggregation and cytotoxicity for the development of Alzheimer’s therapeutics
PROJECT SUMMARY Neurodegeneration in Alzheimer's disease (AD) is increasingly accepted to result from the toxicity of hyperphosphorylated tau aggregates, the major constituent...
Combined RNA Production and Purification Reagents Using Liquid-Liquid Phase Separating Biopolymers
Project Summary The goal of this Phase I SBIR project is to develop a novel purification method that is compatible with in vitro transcription (IVT)-based manufacturing of RNA for...
SDF-1 mRNA gene therapy for restoration of erectile function
Abstract Erectile dysfunction (ED) affects about 18 million men in the U.S. and is estimated to affect 322 million men worldwide by 2025.ED can have a profound negative impact on q...
Clinical Decision Support Tool to Assess Risk and Prevent Agitation Events
PROJECT SUMMARY/ABSTRACT This award is a four-year plan to support Ambrose Wong, MD, MSEd, an emergency physician, in his transition towards an independent research career that foc...
Digital Biomarkers of Ulcerative Colitis Flare
This project will evaluate longitudinally collected physiological metrics, with a focus on autonomic nervous system function (heart rate variability [HRV]), using wearable devices....
The Caregiver Resource Room: Enhancing Support for Caregivers of Alzheimer's Disease and Related Dementias (ADRD)
PROJECT SUMMARY/ABSTRACT With nearly 6 million cases of Alzheimer?s disease and related dementias (ADRD) diagnosed in the United States in 2019, the health and well-being of ADRD c...
Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience
Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. Thus, a high number of children who would benef...
CHOICES for Sickle Cell Reproductive Health: RCT of a Preconception Intervention Model for a Single Gene Disorder
Project Summary/Abstract Our long-term goal is to foster genetically-informed reproductive health knowledge and behaviors among young adults with sickle cell disease (SCD) or sickl...
Identifying Digital Phenotypes of Risk for Alzheimer's Disease and Related Dementias Among Hispanics/Latinos
PROJECT SUMMARY Hispanics/Latinos are at increased risk for developing Alzheimer?s disease and related dementias (ADRD) compared to non-Hispanic Whites.While factors underlying thi...
Identification of new therapeutic targets for ADPKD
Autosomal-dominant polycystic kidney disease (ADPKD) affects more than 12 million people worldwide and is a common cause of end-stage kidney disease (ESKD). ADPKD is caused by muta...
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables Project Summary/Abstract Research: Heart failure is one of the leading caus...
A novel app-based cognitive behavioral therapy intervention for preventing postpartum depression
The prevalence of depression is high after childbirth: rates of postpartum depression (PPD) are as high as 25% among women without prior PPD or depression but with personal or stru...
Harnessing digital data to improve the benefit:harm balance of opioids for non-cancer pain
Background: Opioid use for non-cancer pain has been increasing over the last 15-20-years in North America and Europe and has emerged as a major public health concern in the last de...
The role of cGAS in Senesence and the formation of SADS
Project Summary Aging is characterized by a general decline in overall health and a gradual deterioration across multiple organ systems.However, our understanding of the aging proc...
Non-invasive hemodynamic sensor patch for remote, early detection and prevention of heart failure with left bundle branch block
1 Project Abstract 2 The long-term goal of this SBIR is to develop a remote, non-invasive early-warning system for heart 3 failure progression in presymptomatic patients at elevate...