Results for Technology
53,864 grants found
Showing 49,461 – 49,480 of 53,864 grants for "Technology"
An Ultrasensitive and Low-Cost p24 Antigen Test for the Early Detection of HIV
PROJECT SUMMARY The goal of this NIH SBIR Phase I proposal is to develop a low-cost and rapid point-of-care (POC) p24 test for early detection of human immunodeficiency virus (HIV)...
Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer
Project Summary/Abstract Colorectal carcinoma (CRC) is the 4th most diagnosed cancer but the 2nd leading cause of cancer death mainly due to its metastatic disease (mCRC) in the li...
Antisense oligonucleotide treatment for Pompe disease
Project Abstract: Pompe disease is a devastating myopathy resulting from the deficiency of the lysosomal enzyme acid alpha- glucosidase (GAA),resulting in accumulation of glycogen...
CAREER: Integrating Interaction, Embodiment, and Emotion to Transform Language Models
When children learn language, they incorporate information from many sources including what they see, touch, smell, hear, and how they feel. Before children can speak, they feel em...
Improving Outcomes for Spanish-Speaking Surgical Patients with Limited English Proficiency
Project Summary In 2018, nearly 67 million people in the US spoke a language other than English at home and, among them, 40% met criteria for limited English proficiency (LEP). Peo...
Improving Outcomes for Spanish-Speaking Surgical Patients with Limited English Proficiency
Project Summary In 2018, nearly 67 million people in the US spoke a language other than English at home and, among them, 40% met criteria for limited English proficiency (LEP). Peo...
Improving Outcomes for Spanish-Speaking Surgical Patients with Limited English Proficiency
Project Summary In 2018, nearly 67 million people in the US spoke a language other than English at home and, among them, 40% met criteria for limited English proficiency (LEP). Peo...
Promoting Effective Self-Management of Chronic Pain with mHealth Neurofeedback
ABSTRACT One in five Americans has chronic pain. Many pharmacological pain interventions exist but increase risk of opioid abuse. There is a critical need to find safe, accessible,...
Molecular and Cellular Analysis of Allograft Loss in Kidney Transplant Biopsies
African Americans (AAs) have higher risk for kidney allograft loss after kidney transplantation compared with other races. Our Deterioration of Kidney Allograft Function Genomics s...
Investigation of self-nucleic acids as a trigger for neuroinflammation
PROJECT SUMMARY Pattern recognition receptors (PRRs) are an essential component of the innate immune system responsible for detecting invading pathogens and activating appropriate...
Molecular and Cellular Analysis of Allograft Loss in Kidney Transplant Biopsies
African Americans (AAs) have higher risk for kidney allograft loss after kidney transplantation compared with other races. Our Deterioration of Kidney Allograft Function Genomics s...
Contribution of DNA replication to epigenetic inheritance in a model multi-cellular organism
Asymmetric cell division (ACD) contributes to cellular diversity during development and adult tissuehomeostasis. ACD generates two genetically identical daughter cells with distinc...
muMS2: an open source R package for analyzing and integrating multi-omics datasets to improve early detection and understanding of colorectal cancer
One in every 20 Americans develops colorectal cancer (CRC) and, once diagnosed, more than one-third will not survive 5-years. Although screening is available, stool assays such as...
Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
PROJECT SUMMARY A major gap in cancer diagnostics is that state-of-the-art imaging and other existing methods fail to reliably detect low levels of cancer known as minimal residual...
Central Amygdala to Lateral Hypothalamus Neuropeptide Y projections as a Target in Sex-Specific Binge-Like Ethanol Consumption in Mice
PROJECT SUMMARY Heavy alcohol use and dependence has become a major public health concern within the United States and across the globe, with limited treatments currently available...
Central Amygdala to Lateral Hypothalamus Neuropeptide Y projections as a Target in Sex-Specific Binge-Like Ethanol Consumption in Mice
PROJECT SUMMARY Heavy alcohol use and dependence has become a major public health concern within the United States and across the globe, with limited treatments currently available...
Investigation of Self-Nucleic Acids as a Trigger for Neuroinflammation
PROJECT SUMMARY Pattern recognition receptors (PRRs) are an essential component of the innate immune system responsible for detecting invading pathogens and activating appropriate...
Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
PROJECT SUMMARY A major gap in cancer diagnostics is that state-of-the-art imaging and other existing methods fail to reliably detect low levels of cancer known as minimal residual...
Adolescent Screening and Personalized Intervention Resource for Mild/Moderate Substance Abuse and Co-Occurring Problems
Project Summary We propose to design and pilot-test a technology-based, multicomponent behavioral health intervention for JIY. The design and functionality of the mobile health int...
Wearable Sensors and AI to Recognize and Evaluate IADLs
Project Summary/Abstract: Mild cognitive impairment (MCI) reportedly affects up to 24% of older adults and involves an associated decline in functional mobility. Individuals with M...