Results for Technology
53,864 grants found
Showing 49,421 – 49,440 of 53,864 grants for "Technology"
A Randomized, Controlled Trial of Sublingual Buprenorphine through Telemedicine vs In-Person Care as Usual in the Treatment of Opioid Use Disorder
Opioid Use Disorder (OUD) effects 1.6 million Americans per year, and contributes to significant morbidity and mortality, driven by the opioid overdose epidemic. Despite 3 FDA appr...
muMS2: an open source R package for analyzing and integrating multi-omics datasets to improve early detection and understanding of colorectal cancer
One in every 20 Americans develops colorectal cancer (CRC) and, once diagnosed, more than one-third will not survive 5-years. Although screening is available, stool assays such as...
Liquid chromatography and mass spectrometry instrument system
This instrument application requests funds to purchase a liquid chromatography (LC) / mass spectrometry (MS) system comprised of a SCIEX 4500 triple stage quadrupole (TSQ) mass spe...
Fluid channel Array Brick (FAB) Blood-Gas Exchangers for building Artificial Lungs for Critical Respiratory Failure Treatment
Project Summary/Abstract Essential life-maintaining O2 and CO2 gas exchange for over 1 million patients worldwide with critical respiratory failure or undergoing heart/lung surgery...
A Randomized, Controlled Trial of Sublingual Buprenorphine through Telemedicine vs In-Person Care as Usual in the Treatment of Opioid Use Disorder
Opioid Use Disorder (OUD) effects 1.6 million Americans per year, and contributes to significant morbidity and mortality, driven by the opioid overdose epidemic. Despite 3 FDA appr...
Adolescent Screening and Personalized Intervention Resource for Mild/Moderate Substance Abuse and Co-Occurring Problems
Project Summary We propose to design and pilot-test a technology-based, multicomponent behavioral health intervention for JIY. The design and functionality of the mobile health int...
Randomized ESRD Trial COmparing CBT alone VERsus with buprenorphine (RECOVER)
PROJECT SUMMARY/ABSTRACT Over 60% of patients with kidney failure treated with long-term hemodialysis report chronic pain from highly prevalent musculoskeletal and neuropathic cond...
Central Amygdala to Lateral Hypothalamus Neuropeptide Y projections as a Target in Sex-Specific Binge-Like Ethanol Consumption in Mice
PROJECT SUMMARY Heavy alcohol use and dependence has become a major public health concern within the United States and across the globe, with limited treatments currently available...
Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD
During the K01 period, I will fill critical gaps in my training through meeting 6 training goals: 1) advance my understanding of the experiences of persons with Alzheimer’s Disease...
Investigation of Self-Nucleic Acids as a Trigger for Neuroinflammation
PROJECT SUMMARY Pattern recognition receptors (PRRs) are an essential component of the innate immune system responsible for detecting invading pathogens and activating appropriate...
Wearable Sensors and AI to Recognize and Evaluate IADLs
Project Summary/Abstract: Mild cognitive impairment (MCI) reportedly affects up to 24% of older adults and involves an associated decline in functional mobility. Individuals with M...
Development of a Highly Accurate Wrist/Ankle-Mount Non-invasive Blood Pressure Monitor for Neonatal Patients
SUMMARY/ABSTRACT More than 340,000 neonates are admitted to the neonatal intensive care unit (NICU) each year in the United States. Monitoring arterial blood pressure (BP) for them...
Adolescent Screening and Personalized Intervention Resource for Mild/Moderate Substance Abuse and Co-Occurring Problems
Project Summary We propose to design and pilot-test a technology-based, multicomponent behavioral health intervention for JIY. The design and functionality of the mobile health int...
Development of a Highly Accurate Wrist/Ankle-Mount Non-invasive Blood Pressure Monitor for Neonatal Patients
SUMMARY/ABSTRACT More than 340,000 neonates are admitted to the neonatal intensive care unit (NICU) each year in the United States. Monitoring arterial blood pressure (BP) for them...
NIHR CLEAN-Air(Africa) Unit “Clean modern energy for all”. Benefitting health, society, environment and climate in sub-Saharan Africa to achieve the 2030 Sustainable Development Goals.
Globally 3.8 billion people rely on polluting fuels (e.g. wood, charcoal, kerosene) for cooking. Household air pollution (HAP) from burning these fuels caused 2.3 million premature...
Development of PROTACs Targeting Papain-like Protease as Broad-Spectrum Anti-Coronavirus Therapeutics
PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic caused by SARS-CoV-2 has paralyzed much of the world. Encouragingly, a few COVID-19 vaccines have been developed and approved...
Development of PROTACs Targeting Papain-like Protease as Broad-Spectrum Anti-Coronavirus Therapeutics
PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic caused by SARS-CoV-2 has paralyzed much of the world. Encouragingly, a few COVID-19 vaccines have been developed and approved...
Promoting Effective Self-Management of Chronic Pain with mHealth Neurofeedback
ABSTRACT One in five Americans has chronic pain. Many pharmacological pain interventions exist but increase risk of opioid abuse. There is a critical need to find safe, accessible,...
Structural biology core
CORE 4: SRUCTURAL BIOLOGY SUMMARY Structural biology plays a key role in elucidating molecular mechanisms of biological processes and in therapeutic development. De novo structure...
Developing Antivirals Targeting Proteases and Polymerases of Coronaviruses, Picornaviruses and Bunyavirales
PROJECT 2: DEVELOPING ANTIVIRALS TARGETING PROTEASES AND POLYMERASES OF CORONAVIRUSES, PICORNAVIRUSES AND BUNYAVIRALES SUMMARY The goal of this Project is to develop drug-like inhi...