Results for Technology
53,864 grants found
Showing 49,261 – 49,280 of 53,864 grants for "Technology"
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
PROJECT SUMMARY Hematopoietic Stem/Progenitor Cells (HSPC) gene therapy has provided clinical benefits in several patients affected by a variety of genetic diseases, some of which...
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
PROJECT SUMMARY Hematopoietic Stem/Progenitor Cells (HSPC) gene therapy has provided clinical benefits in several patients affected by a variety of genetic diseases, some of which...
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity Testing
PROJECT SUMMARY In vitro 3-D cultures are a promising way to assess delayed mitochondrial toxicity (MtT) caused by antiretroviral therapy. Standard MtT testing requires large numbe...
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity Testing
PROJECT SUMMARY In vitro 3-D cultures are a promising way to assess delayed mitochondrial toxicity (MtT) caused by antiretroviral therapy. Standard MtT testing requires large numbe...
Ground Level Enhancement Event Monitor (GLEEM)
The risks posed by space weather are becoming more widely recognised, and they are now listed on the UK National Risk Register. In particular, hard solar energetic particle (SEP) e...
Molecular Characterization of Autoreactive B Cells in Immune Checkpoint Inhibitor-Induced Autoimmune Sicca
PROJECT SUMMARY Autoimmune sicca can arise spontaneously, as in Sj?gren?s syndrome (SjS), or acutely, as an immune-related adverse event (irAE) following immune checkpoint inhibito...
Collaborative robot (cobot) controlled system for transcranial magnetic stimulation
Transcranial Magnetic Stimulation (TMS) is a method for non-invasive neuromodulation that uses strong currents passed to a coil placed next to the scalp to induce electric fields a...
LetSync: An mHealth approach to HIV care engagement among black men in couples
PROJECT SUMMARY/ABSTRACT (Original proposal) Based on current diagnoses rates, one in two Black men-who-have-sex-with-men (BMSM) will be diagnosed with HIV during their lifetime.In...
Molecular Characterization of Autoreactive B Cells in Immune Checkpoint Inhibitor-Induced Autoimmune Sicca
PROJECT SUMMARY Autoimmune sicca can arise spontaneously, as in Sjӧgren’s syndrome (SjS), or acutely, as an immune-related adverse event (irAE) following immune checkpoint inhibito...
Personalized Clinical Decision Support to Improve Participation in Hospital at Home
PROJECT SUMMARY Inpatient hospitalization is costly – accounting for $1.1 trillion in health care spending annually in the United States – and is associated with high morbidity and...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer. This is a particular concern for...
Just-in-Time, Online, Intelligent Tutoring for Automated System Integration: Developing a Problem-Solving Environment that Enhances Student Learning
This project aims to serve the national interest by creating technology-based tools that help undergraduate students and new engineers learn to integrate automated systems. Automat...
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
PROJECT SUMMARY Hematopoietic Stem/Progenitor Cells (HSPC) gene therapy has provided clinical benefits in several patients affected by a variety of genetic diseases, some of which...
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
PROJECT SUMMARY Hematopoietic Stem/Progenitor Cells (HSPC) gene therapy has provided clinical benefits in several patients affected by a variety of genetic diseases, some of which...
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
ABSTRACT Blood biopsy is a rapidly advancing technology in which circulating elements (DNA, RNA, proteins, exosomes) released from tumor cells are collected and assessed. In most c...
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
PROJECT SUMMARY Hematopoietic Stem/Progenitor Cells (HSPC) gene therapy has provided clinical benefits in several patients affected by a variety of genetic diseases, some of which...
Diurnal Variation in Soil Nitrous oxide Emissions (DIVINE): drivers and mechanisms
Nitrous oxide (N2O) is a potent greenhouse gas (GHG) with a global warming potential 298 times that of carbon dioxide. Agriculture contributes approximately two thirds of anthropog...
Creating Equitable Pathways to Careers in Biotechnology
The Los Angeles/Orange County region supports almost 5,000 life science or biotechnology firms that collectively employ nearly 100,000 people. Over the next five years, the biotech...
Adaptation: Project CREST - Changing Research Experiences, Structures, and (in)Tolerance through the Adaptation of Promising Equity Practices
It is imperative that the U.S. have a thriving academic research community. Yet, women and minority faculty in science, technology, engineering, math (STEM) and the social behavior...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer. This is a particular concern for...