Results for Technology
53,864 grants found
Showing 49,001 – 49,020 of 53,864 grants for "Technology"
Post-transcriptional regulation of germline mRNAs in C. elegans
Project Summary: My lab is interested in defining how the maternal load is established during oogenesis and decoded after fertilization. We know the identity of most important mate...
Validation of Occupancy Images from PET Data. A Novel Endpoint for Drug Discovery
Abstract The most useful application of PET imaging in CNS drug development is to measure occupancy of new drug candidates at target binding sites (e.g., receptors, transporters, a...
Validation of Occupancy Images from PET Data. A Novel Endpoint for Drug Discovery
Abstract The most useful application of PET imaging in CNS drug development is to measure occupancy of new drug candidates at target binding sites (e.g., receptors, transporters, a...
Validation of blood-based predictive biomarkers of therapeutic response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
PROJECT SUMMARY/ABSTRACT Neoadjuvant chemoradiation therapy (nCRT) followed by surgery is the standard of care for patients with locally advanced rectal cancer (LARC), which accoun...
Transforming STEM Professionals into Culturally Responsive STEM Teachers
This project aims to serve the national need of preparing high quality, effective secondary STEM teachers who will serve in high-need school districts. Across the country, high-nee...
REU Site in Interdisciplinary Materials Research
NON-TECHNICAL DESCRIPTIONThe REU Site at Southern Illinois University Carbondale provides research opportunities for an average of 14 undergraduates per year (including 2 supported...
Manufacturing the Future with Supercritical CO2 and Minimum Quantity Lubrication
Currently the dominant approach for cooling and lubricating machining processes, such as drilling, milling and turning, is to use emulsion-based coolants (otherwise known as metalw...
Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer
Abstract Applying CAR T cell therapy to solid tumors such as ovarian cancer (OvCa) is widely considered a major opportunity but also a major challenge and thus the focus of this pr...
Development and Pilot RCT of a Telehealth-delivered Peer Navigation and Coping Skills Intervention to Increase PrEP Uptake and Adherence in Young Black Men who Have Sex with Men
ABSTRACT Young Black men who have sex with men (YBMSM) ages 15-24 are heavily affected by HIV transmission such that, at current rates, it is estimated that about half of Black MSM...
Study of Pathway-Dependent Effects of Luminal Microbial Metabolites Including Short Chain Fatty Acids and Bile Acids in Irritable Bowel Syndrome Through Meta-omics Analysis of Fecal Specimens
PROJECT SUMMARY The gut microbiome and its metabolites including short chain fatty acids (SCFA) and bile acids (BA) regulate gastrointestinal (GI) physiology and carry immense pote...
Validity and Utility of Consumer-based Wearable Fitness Trackers to Monitor Free-Living Physical Activity Energy Expenditure and Sleep in Children 5-12 Years Old
Accurate measurement of free-living physical activity (PA), energy expenditure (EE), and sleep of children (5-12yrs) is complex, with no single method free of limitations. Validati...
Mobile Ecological Momentary Diet Assessment: A Low Burden, Ecologically-Valid Approach to Measuring Dietary Intake in Near-Real Time
ABSTRACT The excessive intake of saturated fat and added sugars has been identified as a leading cause of premature mortality among adults in the U.S. contributing to approximately...
Phase I clinical trial of adoptive transfer of autologous folate receptor-alpha redirected CAR T cells for ovarian cancer
Abstract Applying CAR T cell therapy to solid tumors such as ovarian cancer (OvCa) is widely considered a major opportunity but also a major challenge and thus the focus of this pr...
Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.
Project Summary/Abstract The prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis, neuronal migration, and formation of neu...
HSI Pilot Project: Building Bridges into Math and STEM at San Diego State University-Imperial Valley
With support from the Improving Undergraduate STEM Education: Hispanic-Serving Institutions (HSI Program), this pilot project aims to build math capacity at San Diego State Univers...
Dispersion Strengthened Magnesium Alloys - Solidification of Nanocolloids
Vehicle lightweighting represents a vital strand of an integrated national approach to transport decarbonisation. There is a general agreement that the CO2 emissions from cars need...
C-DIAS RP 2: Implementing contingency management for stimulant use in specialty addiction treatment organizations
C-DIAS RESEARCH PROJECT 2: PROJECT SUMMARY/ABSTRACT This rigorous experiment addresses a critical public health problem--the rising stimulant/opioid epidemic. It advances implement...
Krabbe disease therapy integrating gene transfer with lectin-enhanced enzyme delivery to treat pathologies of the CNS
Krabbe disease (globoid cell leukodystrophy) is a rare inherited disorder caused by a deficiency in the lysosomal enzyme galactosylceramidase (GALC) leading to destruction of the p...
Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men
Abstract Malaysia's HIV epidemic is rapidly expanding, with recent evidence suggesting increasing sexual transmission, especially in MSM. HIV prevalence among MSM is now at an...
Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men
Abstract Malaysia's HIV epidemic is rapidly expanding, with recent evidence suggesting increasing sexual transmission, especially in MSM. HIV prevalence among MSM is now at an...