Results for Technology
53,864 grants found
Showing 48,941 – 48,960 of 53,864 grants for "Technology"
Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults
PROJECT SUMMARY Physical activity and weight management are key components of ideal cardiovascular health but many young adults are insufficiently active and gaining weight rapidly...
Vesicular Acetylcholine Transporter Function in the Central Nervous System
Regulation of the synthesis, storage, release and degradation of the neurotransmitter acetylcholine (ACh) is essential for normal organismal capabilities such as the ability to mov...
US-Japan Workshop on Needs, Priorities and Partnerships to Advance Human-Centered Data for Resilience
Despite significant technological advances in modeling and simulating natural hazard impacts on society, disaster resilience is, at its heart, a matter of human resilience. Thus, w...
Singlet Oxygen-cleavable Prodrugs for Treating Non-Muscle Invasive Bladder Cancers
Bladder cancer (estimated 83,730 new cases and 17,200 death in 2021) is unique in that most (70-80%) of patients are diagnosed with early-stage, non-muscle invasive bladder cancer...
Singlet Oxygen-cleavable Prodrugs for Treating Non-Muscle Invasive Bladder Cancers
Bladder cancer (estimated 83,730 new cases and 17,200 death in 2021) is unique in that most (70-80%) of patients are diagnosed with early-stage, non-muscle invasive bladder cancer...
Relaying radicals for catalytic couplings: Catalysis with SmI2
Synthetic chemistry is the engine that drives the advance of science and technology as man-made molecules and materials are vital to the work of thousands of scientists around the...
Ethics Core (FABRIC)
Bridge2AI: a FAIR AI BRIDGE Center (FABRIC) Ethics Core Summary The use of artificial intelligence (AI), and particularly machine learning (ML), in healthcare opens up many opportu...
Analysis of the Pediatric Heart Network Echocardiogram Database to Establish Left Ventricular Strain Z-scores
PROJECT SUMMARY In children, calculating ejection (EF) and shortening fraction (SF) using echocardiography (echo) is the standard of care for evaluating left ventricular (LV) funct...
Analysis of the Pediatric Heart Network Echocardiogram Database to Establish Left Ventricular Strain Z-scores
PROJECT SUMMARY In children, calculating ejection (EF) and shortening fraction (SF) using echocardiography (echo) is the standard of care for evaluating left ventricular (LV) funct...
Mechanisms and dynamics of allosteric function in proteins
Abstract Biology is driven through the action of proteins. We know that structure often provides the foundation for proteins’ function, but in recent years it has become clear that...
Research and Mentoring Program in Improving Access to Incontinence Care for Older Adults
PROJECT SUMMARY This application for a K24 Midcareer Investigator Award will promote Dr. Alayne Markland’s mentoring and career development in patient-oriented research on lower ur...
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care Project Summary/Abstract X-ray imaging techniques including plain x-ray, tomosynthesis and computed...
Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer
Project Summary/Abstract Colorectal carcinoma (CRC) is the 4th most diagnosed cancer but the 2nd leading cause of cancer death mainly due to its metastatic disease (mCRC) in the li...
Antisense oligonucleotide treatment for Pompe disease
Project Abstract: Pompe disease is a devastating myopathy resulting from the deficiency of the lysosomal enzyme acid alpha- glucosidase (GAA),resulting in accumulation of glycogen...
The Cancer Proteome Atlas: an Integrated Bioinformatics Resource for Functional Cancer Proteomic Data
SUMMARY/ABSTRACT Reverse-phase protein arrays (RPPAs) offer a powerful functional proteomic approach to investigate molecular mechanisms and response to therapy in cancer. MD Ander...
Mechanisms and dynamics of allosteric function in proteins
Abstract Biology is driven through the action of proteins. We know that structure often provides the foundation for proteins’ function, but in recent years it has become clear that...
Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process
PROJECT SUMMARY Liver transplantation is the only cure for liver failure, but many patients die waiting for a transplant due to a vast shortage of donor livers. Insufficient donor...
Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent manner
PROJECT ABSTRACT As of 2018, 30.3 million Americans have been diagnosed with diabetes (10% of the U.S. population with a male sex bias). Its close associations with many chronic di...
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care Project Summary/Abstract X-ray imaging techniques including plain x-ray, tomosynthesis and computed...
Validation of blood-based predictive biomarkers of therapeutic response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
PROJECT SUMMARY/ABSTRACT Neoadjuvant chemoradiation therapy (nCRT) followed by surgery is the standard of care for patients with locally advanced rectal cancer (LARC), which accoun...