Results for Technology
53,864 grants found
Showing 48,921 – 48,940 of 53,864 grants for "Technology"
Clinical Practice Network
PROJECT SUMMARY/ABSTRACT The purpose of the Clinical Practice Network (CPN) of the MATCHES Telehealth Research Center is to provide the environment for conducting and evaluating th...
Intracellular delivery of DNA-editing proteins by viscoelastic cell stretching
Summary/Abstract Immune cell therapies are a powerful new class of “living medicines” for treating cancer and other diseases, but producing them remains laborious, inefficient, and...
PANDAA for universal, pan-lineage molecular detection of filoviruses to enable rapid epidemic response.
Ebolavirus [EBOV] and Marburgvirus [MARV] are filoviruses that cause severe hemorrhagic fevers in humans and primates and are listed among the urgently concerning pathogens priorit...
Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent manner
PROJECT ABSTRACT As of 2018, 30.3 million Americans have been diagnosed with diabetes (10% of the U.S. population with a male sex bias). Its close associations with many chronic di...
Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process
PROJECT SUMMARY Liver transplantation is the only cure for liver failure, but many patients die waiting for a transplant due to a vast shortage of donor livers. Insufficient donor...
The Cancer Proteome Atlas: an Integrated Bioinformatics Resource for Functional Cancer Proteomic Data
SUMMARY/ABSTRACT Reverse-phase protein arrays (RPPAs) offer a powerful functional proteomic approach to investigate molecular mechanisms and response to therapy in cancer. MD Ander...
Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process
PROJECT SUMMARY Liver transplantation is the only cure for liver failure, but many patients die waiting for a transplant due to a vast shortage of donor livers. Insufficient donor...
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care
Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care Project Summary/Abstract X-ray imaging techniques including plain x-ray, tomosynthesis and computed...
Mechanisms and dynamics of allosteric function in proteins
Abstract Biology is driven through the action of proteins. We know that structure often provides the foundation for proteins’ function, but in recent years it has become clear that...
Mechanisms and dynamics of allosteric function in proteins
Abstract Biology is driven through the action of proteins. We know that structure often provides the foundation for proteins’ function, but in recent years it has become clear that...
Mechanisms and dynamics of allosteric function in proteins
Abstract Biology is driven through the action of proteins. We know that structure often provides the foundation for proteins’ function, but in recent years it has become clear that...
Digital Multiplexed Analysis of Circulating Nucleic Acids in Small-Volume Blood Specimens
Abstract Our goal is to develop a technology platform to repeatedly measure cancer biomarkers from a few drops of blood collected from cancer patients at home. Our team identified...
Smartphone-based optical scanner to physiologically assess diabetic foot ulcers
PROJECT SUMMARY One in three people with diabetes mellitus is at risk of diabetic foot ulcers (DFUs), with over 10% amputated. The current global pandemic has driven a significant...
Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults
PROJECT SUMMARY Physical activity and weight management are key components of ideal cardiovascular health but many young adults are insufficiently active and gaining weight rapidly...
Lesions and loss of smooth muscle cells in brain underlies small vessel disease
In response to the FOA, PAR-22-026, we propose an integrated and technologically/conceptually innovative approach to advance our mechanistic understanding of how dysfunction of sma...
Smartphone-based optical scanner to physiologically assess diabetic foot ulcers
PROJECT SUMMARY One in three people with diabetes mellitus is at risk of diabetic foot ulcers (DFUs), with over 10% amputated. The current global pandemic has driven a significant...
Diurnal control of memory allocation by the circadian gene Per1
Project Summary/Abstract: Humans and other animals are governed by an internal circadian clock that regulates the cycling of biological processes, including memory, across the 24h...
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
PROJECT SUMMARY/ABSTRACT Heart failure (HF) and mild cognitive impairment (MCI) are prevalent among older adults in the U.S. Patients with HF are twice as likely to have MCI than p...
Digital Multiplexed Analysis of Circulating Nucleic Acids in Small-Volume Blood Specimens
Abstract Our goal is to develop a technology platform to repeatedly measure cancer biomarkers from a few drops of blood collected from cancer patients at home. Our team identified...
Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults
PROJECT SUMMARY Physical activity and weight management are key components of ideal cardiovascular health but many young adults are insufficiently active and gaining weight rapidly...