Results for Environment
40,772 grants found
Showing 37,801 – 37,820 of 40,772 grants for "Environment"
Nuclear Transport of Extracellular Vesicle Biomaterials
PROJECT SUMMARY Targeting the interaction between cancer and stromal cells in the tumor microenvironment holds great therapeutic potential.Recently, interest in this type of commun...
Assessing the neuroprotective effect of B cell-therapy after intracerebral hemorrhage
ABSTRACT: Intracerebral hemorrhage (ICH) comprises approximately 15% of strokes affecting 2 million people per year worldwide with up to 70% mortality by 5-years; less than 40% of...
Synergistic effect of APOE genotype and obesity in CNS inflammation and risk of Alzheimer's disease
PROJECT SUMMARY We have previously pursued the hypothesis that APOE genotype alters normal brain neurochemistry and structure early in life, generating an environment that alters t...
Trajectories of Cognition in Middle Age: Implications for Alzheimer's Disease and Related Dementias in the U.S.
PROJECT SUMMARY/ABSTRACT The number of Americans with Alzheimer's disease and related dementias (ADRD) is projected to reach 13.8 million by 2050.Given the current lack of dis...
Dysphagia in Hospitalized Persons with Dementia
Project Summary Oropharyngeal dysphagia (OD) is a syndrome that affects up to 84% of hospitalized older adults with Alzheimer's disease and Related Dementias (ADRD), and is as...
Precision base editing for the treatment of motor neuron diseases
Motor neuron diseases (MNDs) such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are a class of progressive neurodegeneration disorders, often caused by m...
Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications
Project Summary: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques th...
Adapting and evaluating an integrated intervention for adolescent substance use and pain during oral surgery
PROJECT SUMMARY Substance use (SU) is most commonly initiated during adolescence.Earlier age of onset is associated with more significant and persistent adverse outcomes, such as i...
Elucidating the Mitochondrial and Nuclear functions of ATP Synthase Subunit ATP5A1 that Maintain Genome Integrity in Response to Oxidative Stress
PROJECT SUMMARY ? Maintenance of genome integrity is a fundamental function of all cellular life.Respiring organisms maintain robust antioxidant systems to defend against pathologi...
dsRNA production and sensing during DNA virus infection
Project Summary Viral infections are known to produce double-stranded RNA (dsRNA), a molecule that is not present at high levels in uninfected host cells. This property of dsRNA is...
dsRNA production and sensing during DNA virus infection
Project Summary Viral infections are known to produce double-stranded RNA (dsRNA), a molecule that is not present at high levels in uninfected host cells. This property of dsRNA is...
dsRNA production and sensing during DNA virus infection
Project Summary Viral infections are known to produce double-stranded RNA (dsRNA), a molecule that is not present at high levels in uninfected host cells. This property of dsRNA is...
Tactical Behaviors for Autonomous Maneuver
**UPDATE 5 APRIL 2024: The proposal submission date has been updated to 24 April 2024. The FOA has been amended to reflect this submission date and include a Question and Answer do...
China Eximbank provides RMB 359 million government concessional loan for Integrated Government Information System (IGIS) Project
China Eximbank provides RMB 359 million government concessional loan for Integrated Government Information System (IGIS) Project On December 23, 2010, China Eximbank and the Govern...
CAREER: Development and Application of First-Principles Dielectric Embedding Many-Body Perturbation Theory for Heterogeneous Interfaces
NONTECHNICAL SUMMARYThis CAREER award supports research and education in computational and theoretical condensed matter and materials physics. The research part of this project foc...
From Active to Smart Matter
NONTECHNICAL SUMMARYThis award supports theoretical and computational research and education to study emergent behavior in active matter. Active matter is a term coined to describe...
The Interconnection between Mouth and Gut: Understanding the Microbial and Host Factors Influencing Susceptibility to Periodontitis and Colitis
Oral Health is fundamentally tied to general health. However, oral health and general health are perceived as separate entities. Pathologies that arise in the mouth can have a prof...
CAREER: Geometries of Topological Defects in 3D Nematics, from Equilibrium Structure to Active Dynamics
NONTECHNICAL SUMMARYThis CAREER award supports theoretical and computational research and education to advance understanding of how complex, functional organization arises in livin...
CAREER: Geometries of Topological Defects in 3D Nematics, from Equilibrium Structure to Active Dynamics
NONTECHNICAL SUMMARYThis CAREER award supports theoretical and computational research and education to advance understanding of how complex, functional organization arises in livin...
INTEGRATED, CIRCULAR, AND DIGITALLY SUPPORTED SUSTAINABLE SOLUTIONS FOR WASTE MINIMIZATION AND CARBON CAPTURE IN BUILDINGS AND THE CONSTRUCTION SECTOR
The construction sector is responsible for over 35% of the EU’s total waste generation, and accounts for about 50% of all extracted resources and an estimated at 5-12% of total GHG...