Results for Environment
40,772 grants found
Showing 37,761 – 37,780 of 40,772 grants for "Environment"
Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications
Project Summary: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques th...
Adapting and evaluating an integrated intervention for adolescent substance use and pain during oral surgery
PROJECT SUMMARY Substance use (SU) is most commonly initiated during adolescence. Earlier age of onset is associated with more significant and persistent adverse outcomes, such as...
Synergistic effect of APOE genotype and obesity in CNS inflammation and risk of Alzheimer's disease
PROJECT SUMMARY We have previously pursued the hypothesis that APOE genotype alters normal brain neurochemistry and structure early in life, generating an environment that alters t...
Dysphagia in Hospitalized Persons with Dementia
Project Summary Oropharyngeal dysphagia (OD) is a syndrome that affects up to 84% of hospitalized older adults with Alzheimer's disease and Related Dementias (ADRD), and is as...
Trajectories of Cognition in Middle Age: Implications for Alzheimer's Disease and Related Dementias in the U.S.
PROJECT SUMMARY/ABSTRACT The number of Americans with Alzheimer's disease and related dementias (ADRD) is projected to reach 13.8 million by 2050. Given the current lack of di...
Age-appropriate flexible pediatric drug delivery systems
ABSTRACT/SUMMARYPediatric medications require dose flexibility to obtain desired therapeutic concentration. Most medications are producedfor adults as capsules and tablets, which a...
Identifying novel regulators of the biogenesis and intracellular trafficking of ApoB lipoproteins
PROJECT SUMMARY - Metabolic syndrome affects up to 1/3 of the US population and is associated with dyslipidemia. In liver and intestine, lipid is catabolized, incorporated into com...
Developing a widely-useable wearable Circadian Profiling System to assess 24-hour behavioral rhythm disruption in people with dementia and their family caregivers
Supplement Project Summary: The parent study (1R41AG069596-01A1) is prototyping and performing initial user testing of a novel wearable-based monitoring system. The system, which w...
Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications
Project Summary: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques th...
Trajectories of Cognition in Middle Age: Implications for Alzheimer's Disease and Related Dementias in the U.S.
PROJECT SUMMARY/ABSTRACT The number of Americans with Alzheimer's disease and related dementias (ADRD) is projected to reach 13.8 million by 2050. Given the current lack of di...
Trajectories of Cognition in Middle Age: Implications for Alzheimer's Disease and Related Dementias in the U.S.
PROJECT SUMMARY/ABSTRACT The number of Americans with Alzheimer's disease and related dementias (ADRD) is projected to reach 13.8 million by 2050. Given the current lack of di...
Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications
Project Summary: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques th...
Molecular and spatial mapping of hypothalamic cell-types using the Xenium analyzer
PROJECT SUMMARY Steroid hormones in humans and other animals coordinate physiological and behavioral processes underlying optimal responses to the social environment. The brain is...
Collaborative Proposal: NSF-DFG Echem: Understanding the Mechanism of Urea Oxidation on Nickel-Based Electrocatalysts
Urea – a common high-nitrogen chemical waste product of mammalian metabolism, and a major component of fertilizer – poses significant threat to water resources from agricultural ru...
CAREER: Understanding Interfaces in Solid State Energy Storage Systems and Cross-Disciplinary Education
Advanced lithium-ion batteries for vehicle transport and renewable electricity grid storage applications could improve domestic energy security but performance gaps in cost and bat...
RTG: Computational Mathematics for Data Science
Computational and data-enabled science has become the third pillar of science, completing theory and experimentation. Its success has been fueled by breakthroughs in scientific com...
Identifying novel regulators of the biogenesis and intracellular trafficking of ApoB lipoproteins
PROJECT SUMMARY - Metabolic syndrome affects up to 1/3 of the US population and is associated with dyslipidemia. In liver and intestine, lipid is catabolized, incorporated into com...
Exploiting the Hydrophobic Glycosyl Pocket of IgG1 for Imaging and Drug Delivery Applications
Project Summary: Due to the rapidly growing importance of antibody-mediated drug delivery, there is a critical need for simple and efficient site-specific conjugation techniques th...
Elucidating the Mitochondrial and Nuclear functions of ATP Synthase Subunit ATP5A1 that Maintain Genome Integrity in Response to Oxidative Stress
PROJECT SUMMARY – Maintenance of genome integrity is a fundamental function of all cellular life. Respiring organisms maintain robust antioxidant systems to defend against patholog...
This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersal
PROJECT SUMMARY Bacteria alternate between a free-swimming lifestyle and existing in sessile communities known as biofilms. The biofilm lifecycle consists of three stages: founder...