Results for Environment
40,772 grants found
Showing 37,721 – 37,740 of 40,772 grants for "Environment"
South Texas Alzheimer’s Disease Center Outreach, Recruitment and Engagement Core
Summary Outreach, Recruitment and engagement (OREC) In 2050, Hispanic adults over age 65 are expected to account for 20% of the population, up from 7% in 20101. However, they remai...
South Texas Alzheimer's Disease Center Clinical Core
Abstract The Mexican-American (MA) Hispanic community is the most rapidly growing minority and is disproportionately affected by Alzheimer’s disease and related dementias (ADRDs)....
South Texas Alzheimer’s Disease Center Outreach, Recruitment and Engagement Core
Summary Outreach, Recruitment and engagement (OREC) In 2050, Hispanic adults over age 65 are expected to account for 20% of the population, up from 7% in 20101. However, they remai...
Development of Optic Nerve Relays to Restore Retinofugal Connections
Project Summary/Abstract Optic neuropathies and retinal diseases are leading causes of irreversible blindness worldwide. Currently, there are no therapies to restore vision loss. W...
Biomaterial technologies for interrogating sex differences in tissue repair and homeostasis
PROJECT SUMMARYAn individuals’ biological sex significantly affects their ability to repair and regenerate tissue. A clear example of this is the reduced ability for women to heal...
Bioactive lipid mediated Endothelial niche regulation of alveolar epithelial repair
Abstract The lung alveolar epithelium is exposed to the environment and pathogens and is thus highly susceptible to injury. Repair of the alveolar epithelium requires the activatio...
Targeted sequencing of cell-free DNA for monitoring of prostate cancer progression
PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) results in more than 160,000 diagnoses in the US each year with essentially all patients eventually progressing to metastatic castr...
Development of Optic Nerve Relays to Restore Retinofugal Connections
Project Summary/Abstract Optic neuropathies and retinal diseases are leading causes of irreversible blindness worldwide. Currently, there are no therapies to restore vision loss. W...
The role of cGAS in Senesence and the formation of SADS
Project Summary Aging is characterized by a general decline in overall health and a gradual deterioration across multiple organ systems. However, our understanding of the aging pro...
Prenatal Origins of Neurometabolic Consequences
1 ABSTRACT 2 3 There is growing incidence of neurodevelopmental disorders (NDD). Causes for NDDs include ischemic 4 placental disorders (IPD) with fetal/intra-uterine growth restri...
Characterizing the Genomic Basis of Immune-Mediated Resilience Against Tuberculosis in an Admixed Peruvian Population
Project Summary/Abstract Tuberculosis (TB) remains the global leading cause of death from an infectious agent. Understanding why some patients present with early symptoms while oth...
Redox defenses and evasion of reactive oxygen species mediated host immunity in Mycobacterium tuberculosis
Project Summary Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), caused 1.4 million deaths in 2017, more than any other pathogen. TB treatment remains di...
Changes in cognition and psychiatric disorder symptoms during cannabis abstinence using a novel discordant twin design
PROJECT SUMMARY/ABSTRACT Changes in the legal landscape of cannabis have occurred simultaneously with increases in use among adults. Research efforts have focused on examining cons...
Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated loci
Abstract The goal of this NIH Pathway to Independence award is to provide Dr. J. Nicholas (Nick) Cochran with a comprehensive training program to prepare him to be a leading indepe...
This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersal
PROJECT SUMMARY Bacteria alternate between a free-swimming lifestyle and existing in sessile communities known as biofilms. The biofilm lifecycle consists of three stages: founder...
iPPSIS: implanted Passive Pressure Sensor Interrogated with (ultra)-Sound
PROJECT SUMMARY/ABSTRACT Changes to cerebral spinal fluid flow (CSF) dynamics may occur with traumatic brain injury, subarachnoid and/or intraventricular hemorrhage, brain neoplasm...
Steroid hormone dependent gene expression and neuroplasticity in the brain
PROJECT SUMMARY Steroid hormones in humans and other animals coordinate physiological and behavioral processes underlying optimal responses to the social environment.The brain is a...
Defining Mechanisms of NAIP5-independent Flagellin Sensing during Bacterial Infection
PROJECT SUMMARY/ABSTRACT: Antibiotic resistant bacterial infections are an immediate public threat to the United States and global healthcare systems.We must gain a deeper understa...
Identifying novel regulators of the biogenesis and intracellular trafficking of ApoB lipoproteins
PROJECT SUMMARY - Metabolic syndrome affects up to 1/3 of the US population and is associated with dyslipidemia.In liver and intestine, lipid is catabolized, incorporated into comp...
An eco-friendly solution to workplace infection risk durng the COVID-19 pandemic and beyond.
SUMMARY/ABSTRACT The COVID-19 pandemic has ravaged the globe in 2020, with a disproportional effect on the working class: healthcare workers, emergency services personnel (police,...