Results for Environment
40,772 grants found
Showing 37,701 – 37,720 of 40,772 grants for "Environment"
Diet-microbe interactions modulating host energy balance
PROJECT SUMMARY/ABSTRACT Obesity affects approximately 35% of adults and 17% of children in the United States increasing the risks of heart disease, stroke and type 2 diabetes. The...
Arsenic and other co-metals in the San Carlos Apache drinking water
ABSTRACT. The broad, long-term objectives of this K01 project are to improve the health of Apache American Indians through a study that examines the association between cancer (CA)...
Biomaterial technologies for interrogating sex differences in tissue repair and homeostasis
PROJECT SUMMARYAn individuals’ biological sex significantly affects their ability to repair and regenerate tissue. A clear example of this is the reduced ability for women to heal...
RNA targeting specificity and immunomodulation by the influenza A virus ribonuclease PA-X
PROJECT SUMMARY/ABSTRACT Although inflammation is needed for the host to defend itself against influenza infection, too much inflammation is detrimental to the host, and contribute...
Digital Biomarkers of Ulcerative Colitis Flare
This project will evaluate longitudinally collected physiological metrics, with a focus on autonomic nervous system function (heart rate variability [HRV]), using wearable devices....
Colliding Epidemics During an Opioid Crisis: Impact of the COVID-19 Pandemic on Determinants of HIV and HCV Transmission Among People Who Inject Drugs
PROJECT SUMMARY/ABSTRACT The U.S. plans to End the HIV Epidemic (EHE) and eliminate hepatitis C virus (HCV) infection by 2030. While progress has been made in many groups including...
MANATEE-T1D: Metformin ANd AutomaTEd insulin delivery system Effects on renal vascular resistance, insulin sensitivity, and cardiometabolic function in youth with Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT: Diabetic kidney disease (DKD) and cardiovascular disease (CVD) remain the leading causes of morbidity and mortality in people with type 1 diabetes (T1D) a...
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause
Over 50% of postmenopausal women are affected by the genitourinary syndrome of menopause (GSM), a progressive, chronic condition related to estrogen decline that includes vaginal a...
Adherence to Physical Activity among Midlife Adults with Chronic Pain: The Role of Acute Increases in Pain during Physical Activity
Project Summary/Abstract Over 25% of midlife adults suffer from chronic pain, and promotion of physical activity (PA) among this population is essential to increasing quality of li...
Colliding Epidemics During an Opioid Crisis: Impact of the COVID-19 Pandemic on Determinants of HIV and HCV Transmission Among People Who Inject Drugs
PROJECT SUMMARY/ABSTRACT The U.S. plans to End the HIV Epidemic (EHE) and eliminate hepatitis C virus (HCV) infection by 2030.While progress has been made in many groups including...
Diet-microbe interactions modulating host energy balance
PROJECT SUMMARY/ABSTRACT Obesity affects approximately 35% of adults and 17% of children in the United States increasing the risks of heart disease, stroke and type 2 diabetes.The...
Malondialdehyde-induced Endothelial Dysfunction in Atherosclerosis
PROJECT SUMMARY/ABSTRACT Malondialdehyde (MDA) is a ubiquitous and highly reactive end product of non-enzymatic lipid peroxidation, which is a central event in atherogenesis. MDA c...
SWI/SNF chromatin remodelers in tumor-associated antigen-specific CD8+ cytotoxic T cells
Project Summary/Abstract: Transcriptional and chromatin dysregulation are hallmarks of cancer.In this project, we functionally characterize alterations in the pioneer transcription...
Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated loci
Abstract The goal of this NIH Pathway to Independence award is to provide Dr. J.Nicholas (Nick) Cochran with a comprehensive training program to prepare him to be a leading indepen...
Impact of COVID-19 related stay-at-home orders on traffic, traffic-related air pollution, and cardiovascular health in New York City
PROJECT SUMMARY/ABSTRACT Globally, air pollution is responsible for an estimated 4.2 million deaths per year. In New York City (NYC), traffic-related air pollution (TRAP) contribut...
Targeted sequencing of cell-free DNA for monitoring of prostate cancer progression
PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) results in more than 160,000 diagnoses in the US each year with essentially all patients eventually progressing to metastatic castr...
MANATEE-T1D: Metformin ANd AutomaTEd insulin delivery system Effects on renal vascular resistance, insulin sensitivity, and cardiometabolic function in youth with Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT: Diabetic kidney disease (DKD) and cardiovascular disease (CVD) remain the leading causes of morbidity and mortality in people with type 1 diabetes (T1D) a...
The role of bidirectional transport of lysosome-related organelles in learning and memorystorage
Project Summary/ Abstract Axonal transport, the movement of cargoes such as organelles between the cell body and the synapse, is key for transporting signals and cargoes that media...
Getting on the same page: Leveraging an inpatient portal to engage families of hospitalized children
PROJECT SUMMARY/ABSTRACT While sharing honest, unbiased health information with parents is endorsed by the American Academy of Pediatrics as critical to improving patient safety, h...
Changes in cognition and psychiatric disorder symptoms during cannabis abstinence using a novel discordant twin design
PROJECT SUMMARY/ABSTRACT Changes in the legal landscape of cannabis have occurred simultaneously with increases in use among adults. Research efforts have focused on examining cons...