Results for Environment
40,772 grants found
Showing 37,661 – 37,680 of 40,772 grants for "Environment"
Defective heme transport in the development of congenital hydrocephalus
PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is a debilitating neurologic condition with complex genetic and environmental inputs, characterized by excessive accumulation...
Changes in cognition and psychiatric disorder symptoms during cannabis abstinence using a novel discordant twin design
PROJECT SUMMARY/ABSTRACT Changes in the legal landscape of cannabis have occurred simultaneously with increases in use among adults.Research efforts have focused on examining conse...
MANATEE-T1D: Metformin ANd AutomaTEd insulin delivery system Effects on renal vascular resistance, insulin sensitivity, and cardiometabolic function in youth with Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT: Diabetic kidney disease (DKD) and cardiovascular disease (CVD) remain the leading causes of morbidity and mortality in people with type 1 diabetes (T1D) a...
The role of enteroendocrine cell differentiation in the success of bariatric surgery
Project Abstract: One of the most prominent reasons to study the mechanisms underlying the success of bariatric surgery is to replicate surgery outcomes with non-invasive treatment...
Nitric oxide immune dependent resistance mechanisms to anti-PD-1 therapy
Project Summary/Abstract I, Joseph Markowitz, MD PhD, am a junior medical oncologist at Moffitt Cancer Center interested in developing immune-based therapeutics for the benefit of...
Host-microbiome interactions after lung transplantation and chronic lung allograft dysfunction
PROJECT SUMMARY/ABSTRACT This project describes a 5-year mentored career development plan with the goal of training the principal investigator to become an independent physician-sc...
Southern California Center for Chronic Health Disparities in Latino Children and Families.
Obesity and related chronic diseases, type 2 diabetes, non-alcoholic fatty liver disease, and dyslipidemia continue to increase in the U.S., and Latinos are disproportionally affec...
The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern
PROJECT SUMMARY Asthma is a chronic inflammatory disease of the airways.Asthma prevalence has increased markedly in the United States, with 19 million adults reporting current asth...
AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma
AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma PROJECT SUMMARY Drug discovery is a laborious, time-consuming, and expensive...
Role of DNA methylation in regulating striatal molecular rhythm alterations in depression
PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is a leading global cause of disability. A prominent feature of MDD is circadian rhythm disturbances. Recent studies have s...
Synaptic Physiology of the Vestibular Periphery
Project Summary. Vestibular afferent responses deviate from the coherent mechanical stimulation imparted by their overlying accessory structures. This implicates further processing...
The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern
PROJECT SUMMARY Asthma is a chronic inflammatory disease of the airways. Asthma prevalence has increased markedly in the United States, with 19 million adults reporting current ast...
Increased risk of STI and HIV among adolescent girls and young women due to COVID-19 and pandemic mitigation: Biological, behavioral, and psychosocial mediators
From late March 2020, in response to COVID-19, Kenya began a lockdown including shuttering schools. On 16th October, rising seniors could return to school to prepare for exams.In w...
The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern
PROJECT SUMMARY Asthma is a chronic inflammatory disease of the airways. Asthma prevalence has increased markedly in the United States, with 19 million adults reporting current ast...
SWI/SNF chromatin remodelers in tumor-associated antigen-specific CD8+ cytotoxic T cells
Project Summary/Abstract: Transcriptional and chromatin dysregulation are hallmarks of cancer. In this project, we functionally characterize alterations in the pioneer transcriptio...
ImpAct of COVID-19 on CaRe TransitOns and Health OutcomeS for Vulnerable PopulationS in Nursing Homes and Home HealthCARE Agencies (ACROSS-CARE)
The COVID-19 pandemic has disproportionately impacted elderly vulnerable populations (i.e., racial/ethnic minorities and rural residents). The high risk for acquiring COVID-19 and...
Metalloprotein Mechanisms of Redox Regulation and Catalysis
Abstract for Metalloprotein Mechanisms of Redox Regulation and Catalysis This proposal covers the three R01 grants funding my laboratory and aims to fill gaps in understanding the...
Investigating the influence of natural social information on infants’ development of emotion understanding
Project Summary/Abstract The ability to perceive and categorize emotion information early in life is crucial for healthy social cognitive development. Prior research has attempted...
Defining the antigenic determinants of the adaptive immune response in IgG4-related disease
This mentored research program aims to develop Dr. Perugino into an independent investigator studying the immunologic mechanisms of fibrosis. The research goals entail the identifi...
Digital Biomarkers of Ulcerative Colitis Flare
This project will evaluate longitudinally collected physiological metrics, with a focus on autonomic nervous system function (heart rate variability [HRV]), using wearable devices....