Results for Environment
40,772 grants found
Showing 37,641 – 37,660 of 40,772 grants for "Environment"
Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors
PROJECT SUMMARY/ ABSTRACT The perturbation of phospho-tyrosine mediated signaling networks is an essential occurrence during the multistep process of tumor development and progress...
ImpAct of COVID-19 on CaRe TransitOns and Health OutcomeS for Vulnerable PopulationS in Nursing Homes and Home HealthCARE Agencies (ACROSS-CARE)
The COVID-19 pandemic has disproportionately impacted elderly vulnerable populations (i.e., racial/ethnic minorities and rural residents).The high risk for acquiring COVID-19 and t...
Characterizing the Genomic Basis of Immune-Mediated Resilience Against Tuberculosis in an Admixed Peruvian Population
Project Summary/Abstract Tuberculosis (TB) remains the global leading cause of death from an infectious agent.Understanding why some patients present with early symptoms while othe...
The Multifactorial Roles of Platelets in Uncomplicated Malaria Infection
Project Summary/Abstract The malaria causing Plasmodium parasite continues to be a major public health threat, with at least 230 million annual cases worldwide.Plasmodium vivax (P...
Targeted sequencing of cell-free DNA for monitoring of prostate cancer progression
PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) results in more than 160,000 diagnoses in the US each year with essentially all patients eventually progressing to metastatic castr...
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause
Over 50% of postmenopausal women are affected by the genitourinary syndrome of menopause (GSM), a progressive, chronic condition related to estrogen decline that includes vaginal a...
Getting on the same page: Leveraging an inpatient portal to engage families of hospitalized children
PROJECT SUMMARY/ABSTRACT While sharing honest, unbiased health information with parents is endorsed by the American Academy of Pediatrics as critical to improving patient safety, h...
Investigating the influence of natural social information on infants’ development of emotion understanding
Project Summary/Abstract The ability to perceive and categorize emotion information early in life is crucial for healthy social cognitive development.Prior research has attempted t...
The role of cGAS in Senesence and the formation of SADS
Project Summary Aging is characterized by a general decline in overall health and a gradual deterioration across multiple organ systems.However, our understanding of the aging proc...
RNA targeting specificity and immunomodulation by the influenza A virus ribonuclease PA-X
PROJECT SUMMARY/ABSTRACT Although inflammation is needed for the host to defend itself against influenza infection, too much inflammation is detrimental to the host, and contribute...
Impact of COVID-19 related stay-at-home orders on traffic, traffic-related air pollution, and cardiovascular health in New York City
PROJECT SUMMARY/ABSTRACT Globally, air pollution is responsible for an estimated 4.2 million deaths per year.In New York City (NYC), traffic-related air pollution (TRAP) contribute...
Redox defenses and evasion of reactive oxygen species mediated host immunity in Mycobacterium tuberculosis
Project Summary Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), caused 1.4 million deaths in 2017, more than any other pathogen. TB treatment remains di...
The epigenetic encoding of learning and memory
Abstract The nervous system requires tight control of transcription for processes such as learning and memory formation.The field of epigenetics seeks to understand how changes to...
A Virtual Project-Based Learning Sandbox for Mimetics and Medically Inspired Classroom Engineering (MiMICRE)
Abstract: The US has many more health science STEM jobs available than qualified workers to do them. We also lag other OECD nations in math and science skills.Better STEM education...
Metalloprotein Mechanisms of Redox Regulation and Catalysis
Abstract for Metalloprotein Mechanisms of Redox Regulation and Catalysis This proposal covers the three R01 grants funding my laboratory and aims to fill gaps in understanding the...
Defining the molecular basis controlling hematopoietic stem cell symmetric and asymmetric divisions
PROJECT SUMMARY AND ABSTRACT Hematopoietic stem cells (HSCs) maintain blood homeostasis through a delicate balance in fate choices of self-renewal and commitment to differentiation...
Neuro-computational mechanisms of social learning and variation along psychiatric symptom dimensions and in autism
PROJECT SUMMARY Social learning is key for acquiring knowledge about the world and for deciding how to act in social situations.By allowing individuals to learn the consequences of...
South Texas Alzheimer’s Disease Center Outreach, Recruitment and Engagement Core
Summary Outreach, Recruitment and engagement (OREC) In 2050, Hispanic adults over age 65 are expected to account for 20% of the population, up from 7% in 20101. However, they remai...
South Texas Alzheimer's Disease Center Clinical Core
Abstract The Mexican-American (MA) Hispanic community is the most rapidly growing minority and is disproportionately affected by Alzheimer?s disease and related dementias (ADRDs).N...
Biomaterial technologies for interrogating sex differences in tissue repair and homeostasis
PROJECT SUMMARY An individuals? biological sex significantly affects their ability to repair and regenerate tissue.A clear example of this is the reduced ability for women to heal...