Results for Environment
40,772 grants found
Showing 37,621 – 37,640 of 40,772 grants for "Environment"
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major threat to global health. Therefore, it is essential that we fully understand the mechanism of viral infe...
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major threat to global health. Therefore, it is essential that we fully understand the mechanism of viral infe...
HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial Clinical Site
PROJECT SUMMARY/ABSTRACT The University of Arkansas for Medical Sciences (UAMS) will be a clinical site for the HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological...
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes
Recent evidence put forth by our group and others suggests type 1 diabetes (T1D) pathogenesis involves a combination of immune, islet, and acinar pancreas defects. In addition to a...
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
Project Summary Human immunodeficiency virus type 1 (HIV-1) remains a major threat to global health. Therefore, it is essential that we fully understand the mechanism of viral infe...
HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial Clinical Site
PROJECT SUMMARY/ABSTRACT The University of Arkansas for Medical Sciences (UAMS) will be a clinical site for the HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological...
Biology-aware machine learning methods for characterizing microbiome genotype and phenotype
PROJECT SUMMARY 1 The Mirarab laboratory designs leading computational methods for answering biological and biomedical ques- 2 tions, focusing on scalability and accuracy.These met...
The Role of Type I Interferons in Factor VIII Inhibitor Formation
Project Summary/Abstract Anti-factor VIII (FVIII) alloantibodies, known as inhibitors, develop in 20-30% of patients with severe hemophilia A following therapy with FVIII infusion....
Enabling study of electrically transduced information from biomolecules with a low-cost, versatile measurement (Versametrics) system
ABSTRACT Most approaches to studying or detecting biomolecules rely on spectroscopic techniques.While much progress has been made using spectroscopy, there is a wealth of informati...
Synaptic Physiology of the Vestibular Periphery
Project Summary.Vestibular afferent responses deviate from the coherent mechanical stimulation imparted by their overlying accessory structures.This implicates further processing b...
Role of DNA methylation in regulating striatal molecular rhythm alterations in depression
PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is a leading global cause of disability. A prominent feature of MDD is circadian rhythm disturbances.Recent studies have sh...
Clinical Decision Support Tool to Assess Risk and Prevent Agitation Events
PROJECT SUMMARY/ABSTRACT This award is a four-year plan to support Ambrose Wong, MD, MSEd, an emergency physician, in his transition towards an independent research career that foc...
Federated Automated Survey Tool (FAST)
Summary/Abstract Public health o?cials within both acute and chronic disease realms have relied predominantly on survey data to gather information on disease prevalence, behavioral...
The Role of Type I Interferons in Factor VIII Inhibitor Formation
Project Summary/Abstract Anti-factor VIII (FVIII) alloantibodies, known as inhibitors, develop in 20-30% of patients with severe hemophilia A following therapy with FVIII infusion....
Development of Optic Nerve Relays to Restore Retinofugal Connections
Project Summary/Abstract Optic neuropathies and retinal diseases are leading causes of irreversible blindness worldwide. Currently, there are no therapies to restore vision loss. W...
Digital Biomarkers of Ulcerative Colitis Flare
This project will evaluate longitudinally collected physiological metrics, with a focus on autonomic nervous system function (heart rate variability [HRV]), using wearable devices....
Defining the antigenic determinants of the adaptive immune response in IgG4-related disease
This mentored research program aims to develop Dr. Perugino into an independent investigator studying the immunologic mechanisms of fibrosis.The research goals entail the identific...
Bioactive lipid mediated Endothelial niche regulation of alveolar epithelial repair
Abstract The lung alveolar epithelium is exposed to the environment and pathogens and is thus highly susceptible to injury.Repair of the alveolar epithelium requires the activation...
Prenatal Origins of Neurometabolic Consequences
1 ABSTRACT 2 3 There is growing incidence of neurodevelopmental disorders (NDD).Causes for NDDs include ischemic 4 placental disorders (IPD) with fetal/intra-uterine growth restric...
Arsenic and other co-metals in the San Carlos Apache drinking water
ABSTRACT.The broad, long-term objectives of this K01 project are to improve the health of Apache American Indians through a study that examines the association between cancer (CA)...