Results for Environment
40,772 grants found
Showing 37,301 – 37,320 of 40,772 grants for "Environment"
Roles of fibrin(ogen) in conformational activation of hemostatic proteinase precursors
Prothrombin and plasminogen, two central hemostatic zymogens, are activated proteolytically by cleavage of an activation loop. The newly formed N-terminus inserts into a binding po...
Quantifying the Race for the Surface via IV-MLSM
Abstract Implant-associated infections are the bane of musculoskeletal tissue engineering. With over 1.5 million total hip and total knee replacement procedures performed each year...
The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters
This project will seek to define the relative risk contributions of microbial and genetic factors to the development of inflammatory bowel disease (IBD) within a cohort of high-ris...
Investigation of Enteric Nervous System Regeneration in Zebrafish Using a Cell Ablation System with Spatio-Temporal Control
This project aims to determine the regenerative capacity of the enteric nervous system (ENS) and identify the cellular and molecular mechanisms that control ENS regeneration. The E...
Integrating Spatial Omics and Drug Imaging to Dissect the Role of Pancreatic Tumor Microenvironment in Drug Resistance
PROJECT SUMMARY This proposal describes a career development program to prepare Dr. Lu for an independent research career that focuses on developing computational and experimental...
A Molecular Case Series: Deep Cellular and Spatial Epigenetic Characterization of Human Colorectal Cancer
PROJECT SUMMARY/ABSTRACT Cancer has long been thought of as a disease caused by genetic mutations that enable a cell to grow out of control. However, there is growing awareness of...
Cellular barcoding of developmental hematopoiesis
PROJECT SUMMARY/ ABSTRACT Hematopoietic stem cells (HSCs) lie at the top of the blood hierarchy and are capable of giving rise to all blood cells of an organism. Consequently, thei...
Redox regulation of the UPR sensor Ire1
Project Summary/Abstract The oxidative protein folding machinery in the endoplasmic reticulum (ER) is currently appreciated as a potentially significant source of reactive oxygen s...
Redox regulation of the UPR sensor Ire1
Project Summary/Abstract The oxidative protein folding machinery in the endoplasmic reticulum (ER) is currently appreciated as a potentially significant source of reactive oxygen s...
Staphylococcus aureus Type 7b Secretion System assembly and regulation
PROJECT SUMMARY Staphylococcus aureus is a pervasive pathogen that causes invasive disease in humans. The type 7b secretion system (T7bSS) of S. aureus transports a specific set of...
Long-term neurocognitive outcomes of HIV-exposed uninfected children
ABSTRACT Climate change disproportionately affects vulnerable populations, including those of lower socioeconomic status, people living with HIV, and young children living in low-r...
Defining and targeting epigenetic plasticity-driven drug resistance and immune escape in melanoma
Project summary Melanoma is a heterogeneous tumor, with a high degree of phenotypic plasticity that allows for rapid adaptation to BRAF-MEK inhibitor therapy. Initial therapeutic r...
Novel regulatory role of nuclear miRNAs in repatterning the transcriptional and post-transcriptional dynamics in MDD brain
The fine-tuning of transcriptional regulation by gene x environment interaction is central to maladaptive processes associated with major depressive disorder (MDD). Research over t...
Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men
Abstract Malaysia's HIV epidemic is rapidly expanding, with recent evidence suggesting increasing sexual transmission, especially in MSM. HIV prevalence among MSM is now at an...
Defining and targeting epigenetic plasticity-driven drug resistance and immune escape in melanoma
Project summary Melanoma is a heterogeneous tumor, with a high degree of phenotypic plasticity that allows for rapid adaptation to BRAF-MEK inhibitor therapy. Initial therapeutic r...
Targeting Microenvironmental Signals in Myeloid Malignancies
ABSTRACT Interactions of stem cells with their surrounding microenvironment are known to be essential for both normal development, and for sustaining self-renewing adult stem cells...
Psychological and neural mechanisms of social-cognitive deficits in ADHD
Project Summary Attention-deficit hyperactivity disorder (ADHD) is prevalent during early and middle childhood, causing substantial disruptions to everyday life of afflicted childr...
The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
Project Summary / Abstract Consumption of cannabis products is increasing in the United States. The prevalence of past month use among adults has grown from 5.8% in 2007 to 11.5% i...
Medical Scientist Training Program
Project Summary The mission of the Harvard/MIT MD-PhD program is to provide an academic and social environment that inculcates in our students the vital importance of rigorous clin...
Neural Representation of Learning Social Interactions in Non-Human Primates
Project Summary/Abstract. Visually guided social behavior, specifically cooperation, is one of the primary forces driving the evolution of intelligence and is critical to the healt...