Results for Environment
40,772 grants found
Showing 37,041 – 37,060 of 40,772 grants for "Environment"
Mechanisms associated with organotropic metastasis
ABSTRACT Most cancer patients with solid tumors die of metastatic disease and organotropic spread is an understudied aspect of metastasis, for which new insights are urgently requi...
Predoctoral Training in Pharmacological Sciences
Project Summary This is a “new” T32 grant application seeking support for Training in the Pharmacological Sciences (TIPS) at the Weill Cornell Graduate School (WCGS). If awarded, t...
Investigating the role of fatty acid metabolism in melanocyte differentiation: Insights into the metabolic requirements of development
PROJECT SUMMARY Melanocytes are a key cell lineage in the skin and are required for skin pigmentation. Defects in melanocyte development and function can lead to pigmentation disor...
Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients
PROJECT SUMMARY Crohn’s disease (CD) is characterized by progressive, transmural inflammation that can affect any region of the gastrointestinal tract. Penetrating complications, m...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...
Maryland Occupational Health and Safety Surveillance Project
Maryland Department of Health FOA: PAR-20-312 State Occupational Safety and Health Surveillance Surveillance Program (U60) Maryland Title: Maryland Occupational Health and Safety S...
Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients
PROJECT SUMMARY Crohn’s disease (CD) is characterized by progressive, transmural inflammation that can affect any region of the gastrointestinal tract. Penetrating complications, m...
Investigating the role of fatty acid metabolism in melanocyte differentiation: Insights into the metabolic requirements of development
PROJECT SUMMARY Melanocytes are a key cell lineage in the skin and are required for skin pigmentation. Defects in melanocyte development and function can lead to pigmentation disor...
Lung Structural and Functional Alterations Following Early-life RSV Infection
Abstract Severe respiratory syncytial virus (RSV) infection has been associated with the development of childhood asthma.In this proposal, our hypothesis will test whether early-li...
Investigating the role of fatty acid metabolism in melanocyte differentiation: Insights into the metabolic requirements of development
PROJECT SUMMARY Melanocytes are a key cell lineage in the skin and are required for skin pigmentation.Defects in melanocyte development and function can lead to pigmentation disord...
Blocking Latent TGF-β2 Activation as a Therapeutic Strategy for Renal Fibrosis
ABSTRACT.Transforming growth factor beta2 (TGF-?2) is an important therapeutic target for renal fibrosis, the principal cause of end-stage renal failure in chronic kidney disease (...
Assessment of the Vitamin D Metabolite Ratio as a Therapeutic Target in Clinical Practice
PROJECT SUMMARY/ABSTRACT Impaired vitamin D metabolism is associated with increased risks of bone disease, cardiovascular disease (CVD) and death among patients with chronic kidney...
Inner Strength and Influencing Factors in Persons Newly Diagnosed with Mild Cognitive Impairment and their Family Care Partners
Project Summary/Abstract: The purpose of this individual National Research Service Award (NRSA) application is to provide the applicant with essential research training to become a...
The representation and modulation of sensory information in the learning and memory center of the Drosophila brain
The brain uses the combined physiology of many cells to transform incoming sensory signals into internal representations.This process is critical for the animal?s survival because...
Chromosomal Instability as a Marker and Mechanism of Radiation Response
ABSTRACT Human Papilloma Virus (HPV) causes nearly 5% of all cancers worldwide and is implicated in 95% of cervical and 70% of oropharyngeal cancers (OPC). Curative platinum-based...
Elucidating the role of SUMO ligase Su(var)2-10 in piRNA-guided transcriptional silencing and repressive chromatin formation
Project Summary: Heterochromatin refers to the compacted and transcriptionally suppressed chromatin state that typically includes repeat-rich regions near chromosomal arm ends, tra...
The terminal steps of cortisol and aldosterone biosynthesis
Excess aldosterone and cortisol production from the human adrenal cortex commonly contributes to hypertension, heart failure, obesity, glucose intolerance, and low bone mass. Cytoc...
Inducing Mirth to Improve Memory in Depression
Major Depressive Disorder (MDD) impacts an estimated 17.3 million adult Americans per year, which places an enormous burden on the affected individuals as well as our healthcare sy...
Do Tumor-Immune Interactions Prime Systemic Tolerance of Triple-Negative Breast Cancer Brain Metastases?
PROJECT SUMMARY / ABSTRACT It is widely estimated that 90% of cancer-related deaths are caused by metastasis. This statistic underscores our inability to manage cancer once it diss...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...