Results for Environment
40,772 grants found
Showing 36,781 – 36,800 of 40,772 grants for "Environment"
The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters
This project will seek to define the relative risk contributions of microbial and genetic factors to the development of inflammatory bowel disease (IBD) within a cohort of high-ris...
Control of extracellular matrix remodeling by CD29+ astrocytes
PROJECT SUMMARY/ABSTRACT Remodeling of the extracellular matrix (ECM) is a central mechanism by which central nervous system (CNS) reward substrates, such as the nucleus accumbens...
The role of endothelial derived Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) in the pathogenesis of COPD
PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and current therapy only treats symptoms but cannot stop progression of...
A new multi-pathway kinase activity assay applied to compound library screening in cancer biology
Project Abstract Dysregulation of protein kinase signaling pathways is a hallmark of most human cancers. Although targeting kinases has been an effective therapeutic strategy in di...
Psychological Drivers of Self-Destructive Behaviors in PTSD
Self-destructive behaviors are frequently comorbid with posttraumatic stress disorder (PTSD) among Veterans, where they are linked to increased distress and impairment. Self-destru...
Integrating Spatial Omics and Drug Imaging to Dissect the Role of Pancreatic Tumor Microenvironment in Drug Resistance
PROJECT SUMMARY This proposal describes a career development program to prepare Dr. Lu for an independent research career that focuses on developing computational and experimental...
Collaborative Research: Integrated distribution models for North American mammals as tests of niche conservatism.
Mapping animal populations is a powerful approach for learning what factors are important to the species. By comparing records of where animals are common, rare, or absent with loc...
Novel regulatory role of nuclear miRNAs in repatterning the transcriptional and post-transcriptional dynamics in MDD brain
The fine-tuning of transcriptional regulation by gene x environment interaction is central to maladaptive processes associated with major depressive disorder (MDD). Research over t...
Defining and targeting epigenetic plasticity-driven drug resistance and immune escape in melanoma
Project summary Melanoma is a heterogeneous tumor, with a high degree of phenotypic plasticity that allows for rapid adaptation to BRAF-MEK inhibitor therapy. Initial therapeutic r...
Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men
Abstract Malaysia's HIV epidemic is rapidly expanding, with recent evidence suggesting increasing sexual transmission, especially in MSM. HIV prevalence among MSM is now at an...
Computational and theoretical fluid mechanics modeling for transport in dense tumors
Intratumoral perfusion has long been recognized as a critical issue in both clinical diagnosis and therapy of dense solid cancerous tumors.In such context, a first-principles mecha...
Novel regulatory role of nuclear miRNAs in repatterning the transcriptional and post-transcriptional dynamics in MDD brain
The fine-tuning of transcriptional regulation by gene x environment interaction is central to maladaptive processes associated with major depressive disorder (MDD). Research over t...
Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men
Abstract Malaysia's HIV epidemic is rapidly expanding, with recent evidence suggesting increasing sexual transmission, especially in MSM. HIV prevalence among MSM is now at an...
Clinical Practice Network
PROJECT SUMMARY/ABSTRACT The purpose of the Clinical Practice Network (CPN) of the MATCHES Telehealth Research Center is to provide the environment for conducting and evaluating th...
Travel: Support for US graduate students and postdocs to attend the 2022 BEPSII international field school
Sea ice plays a critical role in polar ecosystems and in regional and global climate. Sea ice moderates the exchange of carbon dioxide and other gases between the atmosphere and oc...
Development of a Minimally Invasive Partial Circulatory Support Device for Chronic Use
PROJECT SUMMARY The Nautilus pump is a centrifugal, totally implantable, compact, long-lasting partial circulatory assist device implanted via a minimally invasive pacemaker pocket...
fMRI prediction of the severity of alcohol use disorder
PROJECT SUMMARY Alcohol use disorder (AUD) remains a leading cause of morbidity and mortality in the United States, and most people who attempt to quit drinking relapse within six...
Exploring Disrupted H3K27me3 in Mendelian Disorders of the Epigenetic Machinery and Restoring Its Balance as a Therapeutic Approach to Treat Abnormal Growth
Project Summary Growth and neurologic development are fundamental aspects of child health. Both are consistently disrupted in Mendelian disorders of the epigenetic machinery (MDEMs...
fMRI prediction of the severity of alcohol use disorder
PROJECT SUMMARY Alcohol use disorder (AUD) remains a leading cause of morbidity and mortality in the United States, and most people who attempt to quit drinking relapse within six...
Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium Disease
PROJECT SUMMARY/ABSTRACT: The goal of this study is to define cell-specific regulatory networks and key drivers of cellular response to beryllium (Be) that result in the granulomat...