Results for Environment
40,772 grants found
Showing 36,661 – 36,680 of 40,772 grants for "Environment"
The Role of Hormonal Dysregulation in Systemic Sclerosis
Although patients with systemic sclerosis (SSc) have increased disability, morbidity, and mortality, no current FDA-approved medications for SSc prevent or reverse fibrosis. Our lo...
A Computational IMage Analysis Platform (CIMAP) for HuBMAP
Abstract: Advancement in high-resolution microscopy has opened unprecedented opportunities to investigate cells and tissues spatially at sub-micron level, via molecular imaging of...
Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine Development
Project Summary / Abstract Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is a disease that kills 1.4 million people every year. There is no reliable...
FASEB SRC: The Protein Phosphatases Conference
ABSTRACT This application requests support for the 2022 edition of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Protein Phosp...
Psychological Drivers of Self-Destructive Behaviors in PTSD
Self-destructive behaviors are frequently comorbid with posttraumatic stress disorder (PTSD) among Veterans, where they are linked to increased distress and impairment. Self-destru...
Control of extracellular matrix remodeling by CD29+ astrocytes
PROJECT SUMMARY/ABSTRACT Remodeling of the extracellular matrix (ECM) is a central mechanism by which central nervous system (CNS) reward substrates, such as the nucleus accumbens...
Staphylococcus aureus Type 7b Secretion System assembly and regulation
PROJECT SUMMARY Staphylococcus aureus is a pervasive pathogen that causes invasive disease in humans. The type 7b secretion system (T7bSS) of S. aureus transports a specific set of...
Overcoming the triple threat to diversity in the health science workforce: empowering the next gen.
Interventions to enhance the pool of underrepresented minority (URM) groups in the research workforce, including Blacks or African Americans, Hispanics or Latinos, American Indians...
ENACT: Translating Health Informatics Tools to Research and Clinical Decision Making
Several challenges exist in the conduct of EHR-based translational research. First, CTSA hubs vary substantially in their capacity to address challenges in EHR data collection, dat...
Role of the complement C3a receptor on immune and non immune intestinal barrier functions and microbiota in colorectal cancer development
While it was initially believed that only a minority of CRC are driven by inflammation, studies showing that treatment with anti-inflammatory medications may prevent or delay the d...
The Role of Creb5 in Maintaining Synovial Joint Homeostasis
Project Summary/Abstract. The broad, long-term goal of this project is to develop a comprehensive understanding of the regulatory network that regulates the differentiation and mai...
The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute.
PROJECT SUMMARY/ABSTRACT The public health success of FDA’s proposed ban on menthol cigarettes hinges upon whether menthol smokers who are unable to quit smoking switch to non-ment...
The Role of Creb5 in Maintaining Synovial Joint Homeostasis
Project Summary/Abstract. The broad, long-term goal of this project is to develop a comprehensive understanding of the regulatory network that regulates the differentiation and mai...
The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute.
PROJECT SUMMARY/ABSTRACT The public health success of FDA’s proposed ban on menthol cigarettes hinges upon whether menthol smokers who are unable to quit smoking switch to non-ment...
Towards Identifying Optimal NICU Admission Criteria for Late Preterm Infants
Late preterm (34-36 weeks gestational age) infants account for 7% of the 3.76 million live births in the United States annually, or over 263,000 infants each year. Compared to term...
Corticospinal Tract Development in Intrauterine Growth Restriction
Project Summary Infants born following intrauterine growth restriction (IUGR) are at risk for the development of cerebral palsy (CP). However, it is not precisely understood how pe...
Towards Identifying Optimal NICU Admission Criteria for Late Preterm Infants
Late preterm (34-36 weeks gestational age) infants account for 7% of the 3.76 million live births in the United States annually, or over 263,000 infants each year. Compared to term...
Towards Identifying Optimal NICU Admission Criteria for Late Preterm Infants
Late preterm (34-36 weeks gestational age) infants account for 7% of the 3.76 million live births in the United States annually, or over 263,000 infants each year. Compared to term...
Mechanisms for cellular copper import via secreted cuproproteins
Project Summary: Copper is an essential micronutrient and a required redox-active cofactor for enzymes necessary for eukaryotic respiration, oxidative stress resistance, and the pr...
Mechanisms for cellular copper import via secreted cuproproteins
Project Summary: Copper is an essential micronutrient and a required redox-active cofactor for enzymes necessary for eukaryotic respiration, oxidative stress resistance, and the pr...