Results for Environment
40,772 grants found
Showing 36,521 – 36,540 of 40,772 grants for "Environment"
Domain-adaptive federated learning to develop machine learning models for predicting incident and progression of geographic atrophy
Abstract: Age-related macular degeneration (AMD) is one of the leading causes of severe vision loss. Early detection, prompt intervention, and reliable assessment of treatment outc...
PreventT2 Together: Examing the efficacy of couple-based lifestyle intervention to prevent type 2 diabetes
PROJECT SUMMARY/ABSTRACT Nearly half of U.S. adults have or are at risk of developing type 2 diabetes. Lifestyle intervention is efficacious and the first line of prevention among...
Regulation of epithelial junctions stability and turnover by the RhoG exchange factor SGEF
PROJECT SUMMARY Epithelial cells form tightly packed sheets of uniformly polarized cells, with an apical membrane contacting the environment, lateral membranes held together by spe...
Delving into a Unique Transcription Factor Family to Regulate HIV Transcription
ABSTRACT The persistence of latently infected memory CD4+ T cells releasing a low-level trickling of viral RNAs and proteins in people living with HIV (PLWH) on antiretroviral ther...
Optimising Maternal and Perinatal Death Surveillance and Response to prevent future deaths
Research question: Can perinatal and maternal deaths be reduced by implementation of a customised ‘Toolbox’ of interventions to optimise Maternal and Perinatal Death Surveillance a...
Investigation of the preadipocyte primary cilia signalosome
Consequences associated with obesity can be miƟgated by shiŌing adipose Ɵssue expansion from hypertrophic to hyperplasƟc expansion; the former increases overall size of exisƟng adi...
Myelofibrosis impacts the hematopoietic niche through TNF-a
Project Summary/Abstract Myeloproliferative neoplasms (MPNs) are a clonal expansion of hematopoietic cells, and progression leads to deposition of collagen fibers throughout the bl...
Delineating pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey disease
Abstract: The epidermis provides a critical barrier between the body and its environment; it is composed of multiple layers of keratinocytes that form robust connections by assembl...
Machine-learning prediction model for personalized urinary tract infection care in children
PROJECT SUMMARY The overarching goal of Dr. Wang’s proposal is to reduce the known risk of renal injury from febrile urinary tract infection (fUTI) in children by implementing a pr...
Positive food parenting intervention to promote healthy growth in children at risk for obesity
PROJECT SUMMARY/ABSTRACT Given our obesogenic environment with abundant access to energy-dense foods, parents often feel lost about how to help their kids make healthy food choices...
Computational Stability Analysis to Predict Heart Failure after Myocardial Infarction
PROJECT SUMMARY Myocardial infarction (MI) can lead to heart failure (HF), which severely impacts the quality of life of millions of Americans. MI triggers a cascade of cardiac gro...
SitS: Collaborative Research: Understand and Forecast Long-term Variations of in-situ Geophysical and Geomechanical Characteristics of Degrading Permafrost in the Arctic
Climate change is resulting in warming of the permafrost across the Arctic and sub-Arctic, which results in changes in the geological and mechanical properties of soils. Quantifyin...
Addressing Disparities in Polygenic Risk Score for Coronary Heart Diseases in Diverse Populations
PROJECT SUMMARY/ABSTRACT Coronary heart disease (CHD) remains a leading cause of death worldwide, and accurate risk prediction is crucial for early intervention. While clinical ris...
Collaborative Research: GEM: A novel Machine learning technique to Parameterize EneRgetic Electron maps (AMPERE)
Energetic electron precipitation (EEP) occurs when the high-energy electrons trapped in Earth's radiation belts enter the atmosphere and collide with atmospheric particles, de...
INVESTigations of Muscle and Bone Health: Developing Automated Approaches for CT-Based Analyses
PROJECT SUMMARY Obesity is a common, serious, and costly condition among older adults. Weight loss (WL) is an effective strategy to combat obesity-related comorbidities; however, t...
Leveraging a budding yeast model to characterize the functional consequences of mutations in histone genes that are implicated in human disease
PROJECT SUMMARY Histone proteins are crucial for regulating gene expression and accessibility to genomic DNA. Mutations in genes encoding histones cause abnormal gene expression, d...
Role of interleukin-6 signaling on T cell potential of aged hematopoietic stem cells and thymic progenitors
PROJECT SUMMARY/ABSTRACT T cell production declines with age and contributes to decreased immune function and increased susceptibility to infections and cancers in older adults. Th...
Chemical Strategies to Map Bacterial Response to Environmental Change
The Carlson Group applies the diverse tools of chemical biology to understand how bacteria harness their limited genome to inhabit nearly every ecological niche on our planet. Thes...
Medical Student Summer Research Program in Aging and Alzheimer's disease (MSSRPA)
PROJECT SUMMARY / ABSTRACT This T35 application requests funding for the Case Western Reserve University School of Medicine (CWRU SOM) Medical Student Summer Research Program in Ag...
Development and feasibility testing of intervention(s) to support increased participation in active travel in under-represented groups
Background Active travel is beneficial to both our health and our environment. Cycling and walking for commuting can be effective in integrating physical activity into our daily ro...