Results for Environment
40,772 grants found
Showing 36,241 – 36,260 of 40,772 grants for "Environment"
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women.In particular, endometrial cancer (EC) incidence h...
Dissecting the role of clonal evolution in NPM1-mutant AML
Project Summary/Abstract Candidate: I am a postdoctoral fellow in the lab of Dr. Ross Levine in the Human Oncology & Pathogenesis Program at Memorial Sloan Kettering Cancer Cen...
App-Enhanced CBT for Adolescents at High Risk for Severe Mood Disorders
PROJECT SUMMARY This K23 career development award will position the candidate to become an independent clinical researcher with expertise in the application of mobile health (mHeal...
Dynamic OCE with acoustic micro-tapping for in vivo monitoring of skin graft surgeries
Abstract The goal of this project is a develop a non-contact, non-invasive clinical tool to characterize, image and monitor skin grafting procedures using quantitative, volumetric,...
Targeting the Oncogenic Fusion Transcription Factor PAX3-FOXO1 with Small Molecules
PROJECT SUMMARY Fusion transcription factors (TFs) are an enticing class of cancer targets.When present in a malignancy, these chimeric proteins are often the primary oncogenic dri...
The Influence of Dendritic Structure and Function on Binaural Coincidence Detection in the Medial Superior Olive
PROJECT SUMMARY / ABSTRACT The ability to localize sounds in our environment allows us to filter our attention to tasks that deserve it: escaping a predator, capturing our prey, or...
Mechanisms of cysteinyl leukotriene receptor 2 (CysLT2R)-mediated signaling and migration in melanocytes and uveal melanoma
PROJECT SUMMARY (ABSTRACT) Melanocytes comprise a heterogeneous group of neural crest-derived cells that are present in the skin, eyes, ear, heart, and brain. While the function of...
Variant Determinants of African American Limb Pathology in Peripheral Arterial Disease
Abstract Peripheral artery disease (PAD) is caused by atherosclerosis of the peripheral arteries, most commonly in the lower extremities, and affects 8-12 million individuals in th...
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women. In particular, endometrial cancer (EC) incidence...
“Role of Maternal Obesity in Epigenetic and Metabolic Programming and Lower Respiratory Infection Risk in Early Life”
PROJECT SUMMARY/ABSTRACT Dr. Maria Gutierrez is a pediatric allergist, immunologist, and rheumatologist at Johns Hopkins University (JHU). This K23 application will allow Dr. Gutie...
Targeting the Oncogenic Fusion Transcription Factor PAX3-FOXO1 with Small Molecules
PROJECT SUMMARY Fusion transcription factors (TFs) are an enticing class of cancer targets. When present in a malignancy, these chimeric proteins are often the primary oncogenic dr...
Investigating the metabolic regulation of tumor desmoplasia
PROJECT SUMMARY/ABSTRACT The ability of fibroblasts to synthesize extracellular matrix (ECM) proteins is critical for wound healing; however, this program is coopted by cancer cell...
Directing fate, subtype identity and survival in human pluripotent-derived midbrain dopamine neurons
Project Summary Parkinson's disease (PD) is a movement disorder that involves the selective loss of midbrain dopamine (mDA) neurons in the substantia nigra. Human stem cells,...
App-Enhanced CBT for Adolescents at High Risk for Severe Mood Disorders
PROJECT SUMMARY This K23 career development award will position the candidate to become an independent clinical researcher with expertise in the application of mobile health (mHeal...
Dissecting the role of clonal evolution in NPM1-mutant AML
Project Summary/Abstract Candidate: I am a postdoctoral fellow in the lab of Dr. Ross Levine in the Human Oncology & Pathogenesis Program at Memorial Sloan Kettering Cancer Cen...
Archiving parent-child, marital, and family social Interaction videotapes from a 33 year prospective study of the development of risk and resilience in a high risk population
ABSTRACT The Michigan Longitudinal Study (MLS) is unique for a number of reasons: (1) the study is the earliest beginning (age 3-5 for the proband group) high risk yet also populat...
Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity
PROJECT SUMMARY Advancing age and obesity are tightly linked to the increasing global incidence of skeletal diseases. Osteoporosis in particular poses a major public health threat...
Adaptation and Refinement of a Clinically Applicable Phenotypic Battery to Individualize Opioid Use Disorder Treatment for Women Through the Postpartum Period
PROJECT SUMMARY Opioid overdose is a leading cause of pregnancy-associated mortality with most of these events occurring through the 12 months after delivery rather than the 9 mont...
Probing Event Structure in Children's Naturalistic Memory Using Representational Similarity Analysis of Scalp-Recorded EEG
PROJECT SUMMARY/ABSTRACT From an early age, episodic memory supports critical functions such as decision-making in the present, future thinking, development of the self, and social...
Research and mentoring program in shared decision making in the care of older adults
Adults >75-years are the fastest growing segment of the US population and are increasingly receiving medical interventions from which they often have little chance to benefit, s...