Results for Environment
40,772 grants found
Showing 36,101 – 36,120 of 40,772 grants for "Environment"
Inner Strength and Influencing Factors in Persons Newly Diagnosed with Mild Cognitive Impairment and their Family Care Partners
Project Summary/Abstract: The purpose of this individual National Research Service Award (NRSA) application is to provide the applicant with essential research training to become a...
The representation and modulation of sensory information in the learning and memory center of the Drosophila brain
The brain uses the combined physiology of many cells to transform incoming sensory signals into internalrepresentations. This process is critical for the animal’s survival because...
Chromosomal Instability as a Marker and Mechanism of Radiation Response
ABSTRACT Human Papilloma Virus (HPV) causes nearly 5% of all cancers worldwide and is implicated in 95% of cervical and 70% of oropharyngeal cancers (OPC). Curative platinum-based...
Development of a Predictive Response Signature to Anti-Thymocyte Globulin in Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1D) is caused by T cell-mediated destruction of pancreatic β-cells. A combination of genetic and environmental factors contributes to thi...
Regulation of Dynein-Mediated Transport
PROJECT SUMMARY Organization is a fundamental and defining feature of life at all degrees of scale, from the subcellular level all the way up to the level of the organism. On the c...
Regulation of Dynein-Mediated Transport
PROJECT SUMMARY Organization is a fundamental and defining feature of life at all degrees of scale, from the subcellular level all the way up to the level of the organism. On the c...
Collaborative Research: NSFGEO-NERC: P2C2--Understanding Trans-Hemispheric Modes of Climate Variability: A Novel Tree-Ring Data Transect spanning the Himalaya to the Southern Ocean
The mechanisms that govern trans-hemispheric climate linkages and those between the tropics and higher latitudes are not well understood. This gap in knowledge is caused by a lack...
CAREER: LEarning to Search with Structure (LESS), a Unifying Algorithmic Framework for Gray Box Optimization of Biomanufacturing Systems
This Faculty Early Career Development Program (CAREER) grant will contribute to the advancement of national prosperity and economic welfare by studying efficient operations of sing...
Role of astrocyte-based cholinergic neuromodulation in cognition and in the treatment of cognitive disorders
ABSTRACT Neurons are viewed as the cellular correlate of cognition and only target of clinical therapeutics, in part because manipulating neurons rapidly and directly alters behavi...
Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's Disease
PROJECT SUMMARY AND CAREER DEVELOPMENT ABSTRACT There is no therapy that slows the progression of any symptom of Parkinson’s disease (PD), a progressive, age-related neurodegenerat...
Using Induced Pluripotent Stem Cells to Characterize Cystic Fibrosis
Project Summary/Abstract This proposal details a 5-yr plan to prepare the candidate, Ruobing Wang, MD, for a career as an independent physician-scientist positioned to impact our u...
The Health Sciences & Technology Academy – Alabama (HSTA-AL)
Project Summary/Abstract This innovative project will replicate the successful Health Sciences & Technology Academy from West Virginia, with important adaptations for our purpo...
Role of Monolayer Curvature in Lung Surfactant Morphology and Mechanics
ABSTRACT: Native lung surfactant (LS) coats the air-water interface of the pulmonary alveoli, reducing its sur- face tension and stabilizing the lung from collapse. Virtually every...
Engineering a Vascularized Brain-Chip for Probing and Evaluating Mechanisms of Alzheimer’s Disease
An estimated 1 in 10 Americans age 65 and older are currently living with Alzheimer’s Disease (AD), yet there is still no pharmacologic treatment available that can slow or stop th...
Link between early gut dysfunction and amyloid beta aggregation in Alzheimer's Disease related dementia
PROJECT SUMMARY In recent years, it has become apparent that a “gut-brain” axis exists where communication occurs between the gut, its microbiota, the immune system and the brain....
Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's Disease
PROJECT SUMMARY AND CAREER DEVELOPMENT ABSTRACT There is no therapy that slows the progression of any symptom of Parkinson’s disease (PD), a progressive, age-related neurodegenerat...
Link between early gut dysfunction and amyloid beta aggregation in Alzheimer's Disease related dementia
PROJECT SUMMARY In recent years, it has become apparent that a “gut-brain” axis exists where communication occurs between the gut, its microbiota, the immune system and the brain....
The Health Sciences & Technology Academy – Alabama (HSTA-AL)
Project Summary/Abstract This innovative project will replicate the successful Health Sciences & Technology Academy from West Virginia, with important adaptations for our purpo...
Role of astrocyte-based cholinergic neuromodulation in cognition and in the treatment of cognitive disorders
ABSTRACT Neurons are viewed as the cellular correlate of cognition and only target of clinical therapeutics, in part because manipulating neurons rapidly and directly alters behavi...
Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's Disease
PROJECT SUMMARY AND CAREER DEVELOPMENT ABSTRACT There is no therapy that slows the progression of any symptom of Parkinson’s disease (PD), a progressive, age-related neurodegenerat...