Results for Environment
40,772 grants found
Showing 36,081 – 36,100 of 40,772 grants for "Environment"
NeoSep-ADAPT: Synthesizing Real World Data, systematic reviews, patient and public input, expert consensus and clinical staff perspectives to develop and pilot a master protocol for an adaptive platform trial of neonatal sepsis management.
Sepsis continues to be a major driver of mortality as well as acute and chronic morbidity among neonates requiring hospital-care.Because of the potentially catastrophic outcomes, m...
Role of Trem1 in ultraviolet radiation-induced immune suppression
Ultraviolet B (UVB) radiation (290-320 nm) causes immune suppression, in addition to inducing mutant cells. Tumors will occur only when there are mutant cells in an immune suppress...
Role of Trem1 in ultraviolet radiation-induced immune suppression
Ultraviolet B (UVB) radiation (290-320 nm) causes immune suppression, in addition to inducing mutant cells. Tumors will occur only when there are mutant cells in an immune suppress...
Role of Trem1 in ultraviolet radiation-induced immune suppression
Ultraviolet B (UVB) radiation (290-320 nm) causes immune suppression, in addition to inducing mutant cells. Tumors will occur only when there are mutant cells in an immune suppress...
Role of Trem1 in ultraviolet radiation-induced immune suppression
Ultraviolet B (UVB) radiation (290-320 nm) causes immune suppression, in addition to inducing mutant cells. Tumors will occur only when there are mutant cells in an immune suppress...
Synthetic biology and organelle genomics: A rubisco library as a case study in evolutionary landscapes and organellar engineering
Food security is a critical issue facing human health in the 21st century as the global population approaches 10 billion and climate change threatens the food supply. Photosyntheti...
COVID-19: High Efficiency SARS-CoV-2 Virus Aerosol Sampling and Sensing
As the current COVID-19 pandemic has demonstrated, aerosolized pathogens such as SARS-CoV-2 can spread explosively if not quickly detected.Early detection of these airborne pathoge...
Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function
Project Summary Hematopoiesis involves the continuous production of red blood cells (erythrocytes), immune cells (leukocytes) and blood clotting platelets over the lifespan of the...
Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function
Project Summary Hematopoiesis involves the continuous production of red blood cells (erythrocytes), immune cells (leukocytes) and blood clotting platelets over the lifespan of the...
Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function
Project Summary Hematopoiesis involves the continuous production of red blood cells (erythrocytes), immune cells (leukocytes) and blood clotting platelets over the lifespan of the...
Improving antibiotic treatment decisions through machine learning
PROJECT SUMMARY / ABSTRACT Infections from antibiotic resistant bacteria represent one of the biggest challenges facing modern medical care. Suboptimal antibiotic use is one of the...
Building Quantum Information Science Intuition through Digital Games
This Innovations in Development project is funded by the Advancing Informal STEM Learning program, which seeks to advance new approaches to, and evidence-based understanding of, th...
Investigating the role of fatty acid metabolism in melanocyte differentiation: Insights into the metabolic requirements of development
PROJECT SUMMARY Melanocytes are a key cell lineage in the skin and are required for skin pigmentation. Defects in melanocyte development and function can lead to pigmentation disor...
Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function
Project Summary Hematopoiesis involves the continuous production of red blood cells (erythrocytes), immune cells (leukocytes) and blood clotting platelets over the lifespan of the...
Blocking Latent TGF-β2 Activation as a Therapeutic Strategy for Renal Fibrosis
ABSTRACT. Transforming growth factor beta2 (TGF-β2) is an important therapeutic target for renal fibrosis, the principal cause of end-stage renal failure in chronic kidney disease...
Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuits
Project summary The mammalian brain is remarkably dynamic and can quickly adjust its functional state in response to changes in the environment. For example, when a salient event o...
Revealing Principles of Subcellular RNA Localization by Proximity Labeling
PROJECT SUMMARY The human body comprises of trillion of cells, which are the building blocks of life. Each cell is highly organized, with various constituents within localizing to...
Elucidating the role of SUMO ligase Su(var)2-10 in piRNA-guided transcriptional silencing and repressive chromatin formation
Project Summary: Heterochromatin refers to the compacted and transcriptionally suppressed chromatin state that typically includes repeat-rich regions near chromosomal arm ends, tra...
Microbiomal Mediators of TL1A-induced-Fibrosis
ABSTRACT Inflammatory Bowel Disease (IBD) results from a series of complex interactions between susceptibility and severity genes, the environment and the mucosal immune system, pr...
Racial/Ethnic Differences in Palliative Care Services and Potentially Avoidable Hospitalizations at End-of-Life in Nursing Homes Nationwide
On any day, approximately 1.6 million Americans live in the nation’s nursing homes (NHs) and 90% of the residents are ≥ 65-years old. In the last two decades, there has been an inc...