Results for Environment
40,772 grants found
Showing 36,061 – 36,080 of 40,772 grants for "Environment"
Metabolic impact of Intralipid on synaptic function as a mechanism of resuscitation in local anesthetic systemic toxicity
Project Summary Intravenous lipid emulsions (ILEs) are important therapies. Though designed for parenteral nutrition, they were discovered to be an antidote for local anesthetic sy...
Towards a Quantum-Mechanical Understanding of Redox Chemistry in Proteins
Project Summary/Abstract Metals are found in almost every protein that serves a biological function, and understanding their role in the chemical reactions that guide metabolism an...
Cellular and Molecular Response to Gentamicin-Induced Injury in Underdeveloped Kidneys
PROJECT SUMMARY Humans born before 34-36 weeks of gestation age have low nephron endowment and a 2-3-fold increased risk of chronic kidney disease (CKD). Preterm infants are also a...
Towards a Quantum-Mechanical Understanding of Redox Chemistry in Proteins
Project Summary/Abstract Metals are found in almost every protein that serves a biological function, and understanding their role in the chemical reactions that guide metabolism an...
ANT LIA: Collaborative Research: Adaptations of Southern Ocean Diatoms to Manganese Scarcity: Can Physiological Ingenuity Overcome Unfavorable Chemistry?
The current understanding of what controls productivity in the Southern Ocean is based mostly on the scarcity of a metal compound needed for algal growth, Dissolved Iron in seawate...
Organotypic whole hemisphere models to probe structure-function in neurodevelopment and neurological disease
The brain is our most complex organ and governs everything from cognition and emotion to movement and stress response. Much of the brain’s function is determined by interactions of...
FREEpHRI: Flexible, Robust and Efficient physical Human-robot Interaction with iterative learning and self-triggered role adaption
Globally, the number of robots in use in 2020 is over 2.25 million, which will multiply even faster in the next 10-years, reaching 20 million by 2030. The fast adoption of robots h...
Investigating the metabolic regulation of tumor desmoplasia
PROJECT SUMMARY/ABSTRACT The ability of fibroblasts to synthesize extracellular matrix (ECM) proteins is critical for wound healing; however, this program is coopted by cancer cell...
Investigating the metabolic regulation of tumor desmoplasia
PROJECT SUMMARY/ABSTRACT The ability of fibroblasts to synthesize extracellular matrix (ECM) proteins is critical for wound healing; however, this program is coopted by cancer cell...
Transcriptional activation of RCOR2 as a novel oncogenic mechanism in supratentorial ependymoma
PROJECT SUMMARY Brain and other tumors of the central-nervous system (CNS) are the most common cancers in children aged 0-14-years in the USA. Ependymoma (EPN) is the third most co...
Defining Sex-Specific Systemic and Gut Inflammatory Profiles in People Living with HIV
Project summary Women living with HIV may have a unique, but currently ill-defined inflammatory response to chronic HIV infection. Despite generally having lower viral loads then m...
Defining Sex-Specific Systemic and Gut Inflammatory Profiles in People Living with HIV
Project summary Women living with HIV may have a unique, but currently ill-defined inflammatory response to chronic HIV infection. Despite generally having lower viral loads then m...
Revealing the role of blood microbiome in childhood asthma
Project Summary/Abstract Asthma is one of the most common chronic respiratory diseases worldwide. Microbial dysbiosis in the gut and lungs has increasingly been associated with the...
Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
PROJECT SUMMARY. Type 1 diabetes (T1D) is historically described as an endocrine (β-cell) specific autoimmune disease. However, reduced pancreatic size and subclinical exocrine ins...
The Genetic Architecture of Diabetic Retinopathy
The Genetic Architecture of Diabetic Retinopathy Project Summary/Abstract Diabetic retinopathy (DR) is the leading cause of vision loss and preventable blindness in adults, afflict...
Vanderbilt Stimulating Access to Research in Residency (V-StARR)
The goal of this application is to continue the highly successful Vanderbilt - Stimulating Access to Research in Residency; V-StARR) mentored training program for residents in Medi...
Characterizing Evoked Potentials of Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation (DBS) is a surgical intervention used to treat the cardinal motor symptoms of Parkinson’s disease (PD) when medical interventions fail. While DBS for the mot...
The role of the osteocyte in responses to osteoporosis anabolic treatment in humans and mice
Osteoporosis and other diseases of bone fragility are treated with two classes of drugs: Anti-resorptives (bisphosphonates, antibodies to RANKL) or anabolics, and their sequential...
EFRI ELiS: Biofilm-functionalized and -maintained, living infrastructure systems
Infrastructure is essential for the safety, economic well-being and health of our nation. However, continuing to build and maintain infrastructure using traditional, solely structu...
Decoding Speech using Invasive Brain-Computer Interfaces based on Intracranial Brain Signals (dSPEECH)
Some patients cannot speak because of impairment or degeneration of neural pathways recruited in speech production or movement such as motor neurone disease (MND) or amyotrophic la...