Results for Environment
40,772 grants found
Showing 35,981 – 36,000 of 40,772 grants for "Environment"
Advancing technologies for the collection and analysis of high dimensional immunoprofiles and tumor images
SUMMARY-ABSTRACT The overall goal of this proposal is to use highly multiplexed, high-resolution imaging of tissues and tumors to deeply characterize the microenvironments of diver...
Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's disease
PROJECT SUMMARY Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with severe impairment of memory, cognition and executive functions that has a tremendous healt...
Outreach
PROJECT SUMMARY OUTREACH CORE The Outreach Core (OC) will be a multi-faceted arm of NeuroTech Harbor (NTH) to seek out high-risk, high- reward technology ideas in the neurotechnolo...
Developing a Temporally-Regulated Gene Therapy for Therapeutic Angiogenesis
Project Summary/Abstract Cardiovascular diseases affect millions of patients worldwide and account for nearly a third of deaths globally. Ischemia, or a reduced blood supply, occur...
Using artificial intelligence to support efficient same-day diagnostic imaging in breast cancer screening
Breast cancer is the most common solid cancer and the second leading cause of cancer death among U.S. women. Multiple studies have shown that screening mammography decreases breast...
Assessing how ocular surface nerves, immune cells, and epithelial cells communicate to encourage neuro-immune homeostasis
PROJECT SUMMARY The nature and function of ocular surface nerves play a critical role in maintaining ocular surface health while preventing disease. Disruption of ocular surface se...
Planning grant for a multi-site trial to examine the effectiveness of recovery community centers serving Black communities to support persons using medications for opioid use disorder
Project Summary To address the ongoing opioid epidemic, the U.S. Department of Health and Human Services (HHS) seeks to improve access to treatment and recovery services. Currently...
Buildings on the Grid Edge
To support the decarbonisation of our energy system and to enable increased renewables-penetration into our energy mix, the UK's energy system requires new forms of flexibilit...
The Development of Recyclable Hybrid Solid Electrolytes for Battery Applications
The exponential growth in rechargeable battery technologies over the last 20-years is due to the rising demand for portable electronics, but more recently, batteries have become an...
Moving Target Cyber Defence for Operational Technology
Those targeted Operation Technology (OT) attacks seen in the public domain to date (e.g. Stuxnet, Triton, CrashOverride, BlackEnergy in Ukraine) demonstrate that attackers require...
Development of a robotic directed evolution approach to whole cell biosensor production
Whole cell biosensors are single-celled organisms that have been re-engineered to detect and respond to elements of their environment. Whole cell biosensors can be used to measure...
Understanding Consumer Harm in Online Multiplayer Video Games
This research aims to understand consumer harm experienced by gamers in online multiplayer video games. Consumer harm (or Consumer Detriment) means any loss, damage, or negative im...
Modulating Alzheimer’s Disease by mTORC1 inhibition to augment lysosomal activity
PROJECT SUMMARY/ABSTRACT: This proposal is in application for a Pathway to Independence Award for Dr. Travis Lear at the Aging Institute at the University of Pittsburgh. Dr. Lear h...
New computational tools for understanding and predicting AD via age-associated DNA methylation changes
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, with late-onset AD affecting about 1 in 9 people over 65-years old in the US. The increasing elderly populat...
Post-GWAS Functional Genomics Analysis to Define Pathogenic Mechanisms for Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is an enigmatic and morbid disease where insights are emerging regarding genetic susceptibility to disease. Genome-wide Associ...
Advancing equitable implementation of genomic medicine in nephrology
There is an immense national investment in Precision Medicine, however fulfillment of its promises depends on broad utilization of genetic testing among nephrologists and patients,...
Examining the Interplay of Negative Social Experiences and Self-Criticism on Suicide Risk in the Lab and Daily Life
Project Summary/Abstract This National Research Service Award will provide essential training and resources for the PI to facilitate her goal of becoming an independent investigato...
Clean Hands Accessible and Manageable for Patients (CHAMPs): A technology-based self-management intervention to improve patient hand hygiene and reduce hand contamination among older adults.
PROJECT SUMMARY/ABSTRACT Our long-term goal to establish sustainable, patient-centered interventions at the patient level to engage patients in safety and prevention by offsetting...
Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohort
PROJECT SUMMARY Alzheimer's disease and related dementias (ADRD) have become a growing public health crisis and are one of the major causes of disability among people over 65....
Advancing equitable implementation of genomic medicine in nephrology
There is an immense national investment in Precision Medicine, however fulfillment of its promises depends on broad utilization of genetic testing among nephrologists and patients,...