Results for Environment
40,772 grants found
Showing 35,921 – 35,940 of 40,772 grants for "Environment"
Real-World Accelerator to evolve the standard of Care and Engagement in clinical studies (RACE)
Incomplete and inconsistent capture of race and ethnicity data from real-world data (RWD) limits the full description of the distribution, safety, and effectiveness of FDA regulate...
The Influence of Nicotine Withdrawal on Oxygen Sensing
PROJECT SUMMARY/ABSTRACT CANDIDATE: Dr. Wollman’s career objective is to establish an independent research program investigating the influence of nicotine withdrawal on oxygen sens...
Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer
PROJECT SUMMARY - PROJECT 2 Most patients with pancreatic cancer (PC) do not survive one year and less than 10% survive five years. This is unfortunate, given the slow rate of grow...
HUMAN-CENTRIC NON-INVASIVE PHYSIOLOGICAL SENSING SYSTEM FOR EARLY DETECTION OF WORKERS? HEAT STRESS IN THE FIELD
HUMAN-CENTRIC NON-INVASIVE PHYSIOLOGICAL SENSING SYSTEM FOR EARLY DETECTION OF WORKERS' HEAT STRESS IN THE FIELD PROJECT SUMMARY Heat stress can abruptly raise the core body t...
Targeting Cysteine Susceptibility in Glioblastoma
Project Abstract Glioblastoma (GBM) is one of the most lethal human cancers. Standard GBM treatments, such as radiation (RT) and temozolomide (TMZ), exhibit poor efficacy with a la...
Targeting antioxidant vulnerabilities in KEAP1/NRF2 mutant NSCLC
The transcription factor NRF2 is a central regulator of cellular redox balance. Mutations in NRF2 and its negative regulator KEAP1 are found in 15-34% of non-small cell lung cancer...
MISC-CBO: A cluster randomized control trial to improve the mental health of OVC in South Africa
ABSTRACT Globally, there are over 16 million orphans and vulnerable children (OVC), with estimates of between 1.9-3.7 million for South Africa (SA). Despite high mental health need...
Determine host surface interactions of MARTX toxin of foodborne Vibrio vulnificus
Project Summary/Abstract The marine pathogen Vibrio vulnificus is a highly lethal Gram-negative bacteria inhabiting coastal waters. It causes intestinal infections via consumption...
Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy
SUMMARY Traditional phase I dose-finding strategies monitor drug response only for two weeks, based on the assumption that it will suffice to observe how therapy affects doubling time...
Navigating the Fentanyl Age with Community Drug Checking
Project Summary The drug supply is in enormous flux with illicitly manufactured fentanyl (IMF) and analogs creating a deadly environment for people who use drugs (PWUD). Claiming 9...
Targeting Cysteine Susceptibility in Glioblastoma
Project Abstract Glioblastoma (GBM) is one of the most lethal human cancers. Standard GBM treatments, such as radiation (RT) and temozolomide (TMZ), exhibit poor efficacy with a la...
The role of phase separation in a transcriptional repression mechanism relevant to Candida albicanspathogenesis.
Project Summary: Candida albicans is an opportunistic fungal pathogen capable of causing mucosal and systemic disease. Oropharyngeal candidiasis (OPC) is a frequent fungal disease...
MISC-CBO: A cluster randomized control trial to improve the mental health of OVC in South Africa
ABSTRACT Globally, there are over 16 million orphans and vulnerable children (OVC), with estimates of between 1.9-3.7 million for South Africa (SA). Despite high mental health need...
Deconstructing Post-Stroke Hemiparesis for Precision Neurorehabilitation
PROJECT SUMMARY / ABSTRACT Dr. David Lin is a Neurocritical Care and Neurorehabilitation specialized Neurologist at VA Providence Health Care System whose career goal is to conduct...
Structure and function of mGluR3 interactions with beta-arrestins and the membrane.
PROJECT SUMMARY This proposal contains a comprehensive program to support a transition toward an independent research career focused on understanding how membrane protein function...
Characterization of Naphthalene DNA Adducts in Mice and Firefighters
Project Summary/Abstract Naphthalene (NA), a simple polycyclic aromatic hydrocarbon, is persistently present in the environment as a byproduct of combustion of fossil fuels and bur...
Multimodal, multiclass prediction of disease status in Alzheimer’s
Project Summary As the number of Americans living with Alzheimer’s disease (AD) is projected to reach 13 million by 2050, we must prioritize efforts for early disease detection. Th...
Determine host surface interactions of MARTX toxin of foodborne Vibrio vulnificus
Project Summary/Abstract The marine pathogen Vibrio vulnificus is a highly lethal Gram-negative bacteria inhabiting coastal waters. It causes intestinal infections via consumption...
Investigating and targeting metabolic vulnerabilities of MYC-driven small cell lung cancer
PROJECT ABSTRACT Small cell lung cancer (SCLC) is a fatal neuroendocrine lung tumor that is challenging to treat due to early metastasis, rapid growth, and a lack of easily targeta...
Functional networks underlying cognitive decline in aging and Alzheimer's disease
Project Summary Aging and Alzheimer’s disease (AD) are characterized by progressive cognitive decline, ranging from mild to severe deficits in episodic memory and executive functio...