Results for Environment
40,772 grants found
Showing 35,901 – 35,920 of 40,772 grants for "Environment"
Collaborative Research: WoU-MMA: The Benchmark Measurement of Quasar Spectroscopic Variability and Implications for Supermassive Black Hole Binaries and Changing-Look Quasars
Most, if not all, reasonably massive galaxies host supermassive black holes in their centers, with masses of millions to billions of times the mass of the Sun. The most luminous no...
FW-HTF-P: Building Human-Technology Safety Partnerships in Roadside Work Zones
Highway construction and maintenance is reported as one of the most unsafe occupations in the United States. Road workers are six times more likely to be injured or killed during w...
WoU-MMA: IceCube Data Analysis in the U.S. 2022-2025
This award provides funding for U.S. scientists to perform the scientific analysis of data taken with the IceCube Neutrino Observatory (ICNO) located at the U.S. Amundsen-Scott Sou...
Probing functioning lung at the cellular resolution in health and disease
Summary: The lung is the site of many pathophysiologies due to air-borne pathogens, pollutants, and primary and metastatic cancer, and its diverse microenvironment is continuously...
Culturally Adapted Pain Management for Indigenous Peoples in the Pacific Northwest (CAP-I)
PROJECT SUMMARY/ABSTRACT The prevalence of chronic pain is higher among American Indian/Alaskan Native (AI/AN) people than any other group in the United States. Although a number o...
A Human Salivary Glycome Discovery Platform for Interrogating Glycan Function in Oral Innate Immunity
Project summary The oral cavity is the first critical interface between potentially harmful substances or pathogens in the host environment, and evolution of the adaptive and innat...
Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer
PROJECT SUMMARY - PROJECT 2 Most patients with pancreatic cancer (PC) do not survive one year and less than 10% survive five years. This is unfortunate, given the slow rate of grow...
MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
ABSTRACT Preventative and therapeutic strategies for late onset Alzheimer’s Disease (AD) depend on access to reliable biomarkers for early detection, ideally minimally invasive and...
The Influence of Nicotine Withdrawal on Oxygen Sensing
PROJECT SUMMARY/ABSTRACT CANDIDATE: Dr. Wollman’s career objective is to establish an independent research program investigating the influence of nicotine withdrawal on oxygen sens...
Targeting cysteine susceptibility in glioblastoma
Project Abstract Glioblastoma (GBM) is one of the most lethal human cancers. Standard GBM treatments, such as radiation (RT) and temozolomide (TMZ), exhibit poor efficacy with a la...
MISC-CBO: A cluster randomized control trial to improve the mental health of OVC in South Africa
ABSTRACT Globally, there are over 16 million orphans and vulnerable children (OVC), with estimates of between 1.9-3.7 million for South Africa (SA). Despite high mental health need...
Defining and targeting the immune-suppressive metabolic microenvironment of leptomeningeal melanoma metastases
The deadliest complication of late-stage melanoma is leptomeningeal metastasis (LMM), where the cells spread to the cerebrospinal fluid (CSF) space and the membrane coverings of th...
Navigating the Fentanyl Age with Community Drug Checking
Project Summary The drug supply is in enormous flux with illicitly manufactured fentanyl (IMF) and analogs creating a deadly environment for people who use drugs (PWUD). Claiming 9...
HUMAN-CENTRIC NON-INVASIVE PHYSIOLOGICAL SENSING SYSTEM FOR EARLY DETECTION OF WORKERS? HEAT STRESS IN THE FIELD
HUMAN-CENTRIC NON-INVASIVE PHYSIOLOGICAL SENSING SYSTEM FOR EARLY DETECTION OF WORKERS' HEAT STRESS IN THE FIELD PROJECT SUMMARY Heat stress can abruptly raise the core body t...
Health Disparities in Timely Goals of Care Discussions and Hospitalizations Due to Infections in Nursing Home Residents
Over 1.3 million residents live in the 15,600 nursing homes (NHs) across the nation. About 90% of NH residents are 65-years of age or older and more than 50% are in their final sta...
Functional networks underlying cognitive decline in aging and Alzheimer's disease
Project Summary Aging and Alzheimer’s disease (AD) are characterized by progressive cognitive decline, ranging from mild to severe deficits in episodic memory and executive functio...
Investigating and targeting metabolic vulnerabilities of MYC-driven small cell lung cancer
PROJECT ABSTRACT Small cell lung cancer (SCLC) is a fatal neuroendocrine lung tumor that is challenging to treat due to early metastasis, rapid growth, and a lack of easily targeta...
Structure and function of mGluR3 interactions with beta-arrestins and the membrane.
PROJECT SUMMARY This proposal contains a comprehensive program to support a transition toward an independent research career focused on understanding how membrane protein function...
Elucidating the regulation and spread of an integrative and conjugative element from Streptococcus mutans in the oral microbiome
Project Summary/Abstract Microbial evolution is dominated by horizontal gene transfer (HGT), which is prevalent in bacterial biofilms such as dental plaque. HGT is often mediated b...
The role of phase separation in a transcriptional repression mechanism relevant to Candida albicanspathogenesis.
Project Summary: Candida albicans is an opportunistic fungal pathogen capable of causing mucosal and systemic disease. Oropharyngeal candidiasis (OPC) is a frequent fungal disease...