Results for Environment
40,772 grants found
Showing 35,881 – 35,900 of 40,772 grants for "Environment"
Determine host surface interactions of MARTX toxin of foodborne Vibrio vulnificus
Project Summary/Abstract The marine pathogen Vibrio vulnificus is a highly lethal Gram-negative bacteria inhabiting coastal waters. It causes intestinal infections via consumption...
Multimodal, multiclass prediction of disease status in Alzheimer’s
Project Summary As the number of Americans living with Alzheimer’s disease (AD) is projected to reach 13 million by 2050, we must prioritize efforts for early disease detection. Th...
Targeting antioxidant vulnerabilities in KEAP1/NRF2 mutant NSCLC
The transcription factor NRF2 is a central regulator of cellular redox balance. Mutations in NRF2 and its negative regulator KEAP1 are found in 15-34% of non-small cell lung cancer...
Characterization of Naphthalene DNA Adducts in Mice and Firefighters
Project Summary/Abstract Naphthalene (NA), a simple polycyclic aromatic hydrocarbon, is persistently present in the environment as a byproduct of combustion of fossil fuels and bur...
Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)
Project Summary/Abstract This R01 Proposal, “Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in viv...
Palliative Care at Home for Patients with Dementia
PROJECT SUMMARY / ABSTRACT Persons with advanced Alzheimer’s disease and related dementias present unique challenges for the healthcare system; they typically have complex chronic...
Paxillin and Androgens in the Regulation of Ovarian Follicle Development
1 Project Summary / Abstract 2 This career development project will provide a path for a highly qualified candidate with a combined MD/PhD 3 degree into a career as an independent...
Computational Stability Analysis to Predict Heart Failure after Myocardial Infarction
PROJECT SUMMARY Myocardial infarction (MI) can lead to heart failure (HF), which severely impacts the quality of life of millions of Americans. MI triggers a cascade of cardiac gro...
Relating functional MRI to neuronal activity: accounting for effects of microarchitecture
The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits.Functional magnetic resonance imaging (fMRI) has great potential to ach...
Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars
ABSTRACT Over the past 20-years, the BIRCWH Program at the University of Kentucky (UK) has been extremely successful in creating a research environment to prepare early career scie...
Multimodal, multiclass prediction of disease status in Alzheimer’s
Project Summary As the number of Americans living with Alzheimer’s disease (AD) is projected to reach 13 million by 2050, we must prioritize efforts for early disease detection. Th...
Palliative Care at Home for Patients with Dementia
PROJECT SUMMARY / ABSTRACT Persons with advanced Alzheimer’s disease and related dementias present unique challenges for the healthcare system; they typically have complex chronic...
Paxillin and Androgens in the Regulation of Ovarian Follicle Development
1 Project Summary / Abstract 2 This career development project will provide a path for a highly qualified candidate with a combined MD/PhD 3 degree into a career as an independent...
Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer
PROJECT SUMMARY - PROJECT 2 Most patients with pancreatic cancer (PC) do not survive one year and less than 10% survive five years. This is unfortunate, given the slow rate of grow...
Relating functional MRI to neuronal activity: accounting for effects of microarchitecture
The central goal of the BRAIN Initiative is to understand the structure and function of human brain circuits.Functional magnetic resonance imaging (fMRI) has great potential to ach...
Targeting antioxidant vulnerabilities in KEAP1/NRF2 mutant NSCLC
The transcription factor NRF2 is a central regulator of cellular redox balance. Mutations in NRF2 and its negative regulator KEAP1 are found in 15-34% of non-small cell lung cancer...
Deconstructing Post-Stroke Hemiparesis for Precision Neurorehabilitation
PROJECT SUMMARY / ABSTRACT Dr. David Lin is a Neurocritical Care and Neurorehabilitation specialized Neurologist at VA Providence Health Care System whose career goal is to conduct...
Targeting Cysteine Susceptibility in Glioblastoma
Project Abstract Glioblastoma (GBM) is one of the most lethal human cancers. Standard GBM treatments, such as radiation (RT) and temozolomide (TMZ), exhibit poor efficacy with a la...
Collaborative Research: Connecting Models to Observations of Tidal Disruption Events
The disruption and subsequent accretion of stars by super-massive black holes (SMBHs) has been linked to many luminous flares observed in the nuclei of nearby galaxies. Our theoret...
ASCENT: Reconfigurable Metal-Free Microsystems with Alternative Power Sources
This Addressing Systems Challenges through Engineering Teams (ASCENT) project will enable a suite of technologies for sustainable micro- and nano-electronics development. The emerg...