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199,248 grants found
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Nanoparticle-mediated ocular delivery of novel NAD-boosting small molecules for ophthalmic disease.
Metabolic decline may be a critical, and treatable, pathogenic component of glaucoma. Glaucoma is one of the most prevalent neurodegenerations worldwide, affecting 80 million patie...
Services for inter- and cross-disciplinary data discovery, access, sharing and reuse in the EOSC Federation
The EOSC Data Commons project’s mission is to contribute to tThe EOSC Data Commons project’s mission is to contribute to the establishment of EOSC as the European Research Commons,...
A new look at prostitution in medieval Europe: Exploring the potential of ancient pathogen genomics with individuals buried in red light districts.
SEXWARC contributes to a paradigm shift in the archaeology of prostitution. The discipline has thus far mainly been limited to a description of the structural features of which bro...
Mechanical Basis of Genome Organisation through INO80
Recent breakthroughs found that mechanical features of gene promoters influence nucleosome positioning through ATP-dependent chromatin remodeling enzymes. This finding challenges c...
Precision Synthesis of High Entropy Chalcogenide Nanocrystals to Elucidate Growth Kinetics and Surface Properties for Energy Applications
As technology advances, traditional semiconductor materials and designs are approaching their physical and performance limitations. This underscores the urgent need for innovation...
ZBP1-induced Inflammation and REcognition of Z-Nucleic Acids
Nucleic acids are potent inducers of an immune response. Nucleic acids normally exist in a right-handed conformation. However, during conditions of cellular stress, nucleic acids c...
The Challenge of Islam and the Transformation of Eastern Christian Normative Regimes, ca. 630-1100
In the crucial half-millennium between the death of the Prophet Muhammad and the First Crusade, an absolutely essential part in the origins of Christian-Muslim relations has been o...
Restoring the Immune Response in Glioblastoma by Microglial-Targeting of Autophagy Inhibitors.
Glioblastoma is a highly aggressive type of brain cancer that kills around 15,000 people per year in Europe alone. It also has a devastating effect on patients' quality of life. Th...
International circulation of technicians. A prosopographical study about agents and scientists inside Unrra, Fao and Unesco (1943-1960)
The research aims to analyse the role of Unrra, Unesco and Fao in planning a new global order since World War II based on Education, Science and management of the Environment, look...
Operationalizing relational values for a more equitable marine conservation
The global commitment to protect 30% of the oceans by 2030 faces several key challenges in preserving nature without exacerbating existing coastal resource conflicts. As ocean prot...
Probing nuclear parton dynamics in Heavy-Ion Collisions with Hard Probes
Perturbative QCD (pQCD) derived from first principles, is used to predict experimental observations involving large momentum transfer, such as high-energy jet productions in proton...
THE ROLE OF SYNAPSE POLARITY ON THE FORMATION AND PLASTICITY OF INHIBITORY CONNECTIONS
In adults, GABA acts as the primary inhibitory neurotransmitter, but during early development, GABAergic synaptic transmission has depolarising effects and can influence various de...
The role of SYNGAP1 isoforms in brain development
Synaptic Ras GTPase activating protein (SynGAP) is crucial for neuronal communication and is highly concentrated in excitatory synapses. Mutations in the SYNGAP1 gene cause SYNGAP1...
PHOS-SVD: PHOSpholipids in Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) is the leading cause of vascular dementia, plays a significant role in Alzheimer's disease and increases stroke risk, highlighting its critical...
Lithium point-of-care testing to improve adherence to monitoring guidelines and quality of maintenance therapy for bipolar disorder: a randomised feasibility trial.
Lithium is the first-line treatment for bipolar disorder. Due to its narrow therapeutic window and risk of toxicity, people taking lithium require regular blood testing to monitor...
Ultrathin Two-Dimensional Polymer Heterostructure Membranes Enabling Unidirectional Ion Transport
Current separation technology is crucial for many aspects of human life and accounts for ~15% of the worlds energy consumption. While the particle flow through separation columns i...
Delegating decisions: An overlooked way of pursuing immoral goals
Modern societies are tormented by warfare, crime, corruption, and environmental exploitation. If many people have prosocial goals and desire to see themselves and to be seen by oth...
Overcoming Mechanically-Induced Resistance to Chemo-Immunotherapy in Pancreatic Cancer
Cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels, drastically reducing delivery of drugs. My co-workers a...
Evolutionary Arms Races Shaping the Germline Epigenome
Germline chromatin pathways are key to the stable inheritance of genetic and epigenetic information. They also participate in intense evolutionary battles between genetic entities...
Neuronal implementation of cognitive maps for navigation
Intelligent behavior is based on internal models of the world that enable mental simulations and strategic planning. A leading model to study such “cognitive maps” are networks of...