Results for Environment
40,772 grants found
Showing 35,341 – 35,360 of 40,772 grants for "Environment"
Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk
PROJECT SUMMARY Structural racism (SR) is defined as mutually reinforcing systems, such as income, education and housing, that disadvantage ethnoracially minoritized individuals. S...
Project 1: Combined Suppression of MYC as therapy for CRPC: the COSMYC trial
PROJECT 1 – PROJECT SUMMARY Prostate cancer cells (PCa) are highly adaptable in response to the tumor microenvironment. In response to chronic exposure to a low testosterone enviro...
Characterization of the Staphylococcus aureus fatty acid degradation pathway
PROJECT SUMMARY/ABSTRACT Bacteria require fatty acids for a variety of biological functions, including the construction of phospholipids. Staphylococcus aureus, like other bacteria...
A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children
Project Summary/Abstract: Sleep is essential for optimal health and development. Poor sleep is associated with impaired functioning and academic performance, and worse health outco...
Effect of mutant HTT on the development and maturation of astrocytes
Project Summary / Abstract: Astrocytes are known to be dysfunctional in Huntington’s disease (HD); however, further research is needed to understand how these star-like cells devel...
Understanding the functional role of fibroid subtype mutations for drug discovery
PROJECT SUMMARY/ABSTRACT Research Project: Uterine fibroids are the most common benign tumors in women of reproductive age. The economic impact of symptomatic uterine fibroids in t...
Reliable Question-Answering Frameworks for Clinical Decision Support using Domain-specific Large Language Models
PROJECT SUMMARY/ABSTRACT Timely and accurate clinical decision-making is critical for the quality of healthcare delivery, impacting everyone from individual patients to entire publ...
Modulatory effects of a retinoid-related protein on intestinal endocrine cells
PROJECT SUMMARY The gastrointestinal tract is the largest endocrine organ in the human body. This is due to the presence of intestinal endocrine cells, a scarce yet important cell...
Nanoparticles to reprogram innate immune cells and disrupt the metastatic niche
Summary. Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that is treated with neo-adjuvant therapy that targets both the primary tumor and systemic dise...
Improving Biopsychosocial Outcomes of Older Adults Facing Fecal Ostomy Surgery
Project Summary. In this K76 proposal, I outline a comprehensive 5-year training program that will support my transition to independence as an emerging leader. The proposal focuses...
Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma
PROJECT SUMMARY/ABSTRACT Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Thus far, eff...
Parents helping Parents for Youth Vaping Cessation (PhP-VX)
Project Summary Youth electronic cigarette (e-cigarette) use is a public health concern. Many youths are eager to quit vaping, and our prior study estimated that 67.3% of adolescen...
The Role of the Exposome and Allostatic Load in Risk and Resilience to Youth Suicide Attempts
ABSTRACT Suicide is the second leading cause of death in US youth. Suicidal behavior is complex and is influenced by a combination of multi-level distal and proximal environmental...
Optimizing hematopoietic stem cell transplantation to treat non-malignant disease
Project Summary/Abstract This proposal outlines the five-year research and career development plans for the PI, Stephen P. Persaud, MD, PhD, who is preparing for a career as an aca...
The adult leopard gecko, an emerging, unconventional experimental model for dental research
7. PROJECT SUMMARY The long-term goal of the proposed research is gain fundamental insights into the process of tooth generation and loss using the innovative leopard gecko model....
Measuring the Impact of Structural Gendered Racism on Black Women’s Cognitive Aging and Risk of Alzheimer’s Disease and Related Dementia: A Mixed-Methods Investigation
PROJECT ABSTRACT Disparities in Alzheimer’s disease and related dementias (ADRD) exist across race as well as sex/gender, and structural oppression is hypothesized to be an importa...
Collaborative Research: SAI: Safe bicycle infrastructure: Preparing for an e-bike future
Strengthening American Infrastructure (SAI) is an NSF Program seeking to stimulate human-centered fundamental and potentially transformative research that strengthens America’s inf...
Collaborative Research: SAI: Safe bicycle infrastructure: Preparing for an e-bike future
Strengthening American Infrastructure (SAI) is an NSF Program seeking to stimulate human-centered fundamental and potentially transformative research that strengthens America’s inf...
Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity
PROJECT SUMMARY The young brain displays remarkable plasticity. This includes an ability to remodel neuronal synaptic connections to learn new tasks in health, as well as being abl...
An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation
ABSTRACT Cigarette smoking is the leading cause of preventable death and disability in the United States. Smoking cessation rates have stagnated in recent years, underscoring the n...