Results for Environment
40,772 grants found
Showing 35,201 – 35,220 of 40,772 grants for "Environment"
Modeling Product Selectivity in Electrocatalytic Carbon Dioxide Reduction Using Scaling Relationships
Project Summary The Wood-Ljungdahl (WL) pathway is a CO2 fixation pathway that relies on two different CO2 reducing enzymes — formate dehydrogenase (FDH) and carbon monoxide dehydr...
Resolving the Hierarchy and Regulation of Sebaceous Gland Stem Cells
PROJECT SUMMARY Sebaceous glands (SGs) are appendages of mammalian skin that produce and secrete a mixture of lipids, known as sebum. Sebum production is crucial for skin maintenan...
Minimizing Hypoglycemia in Adults with Type 1 Diabetes through an Integrated Mobile Health and Continuous Glucose Monitoring System
Project Summary / Abstract Level 2 hypoglycemia (blood glucose
Neighborhood perceptions and response to a technology-assisted parenting intervention for youth substance use
PROJECT SUMMARY An adolescent’s neighborhood is associated with their likelihood of developing a substance use disorder. Technology-assisted interventions (TAIs) have been touted t...
Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methods
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects approximately 1 million people in the US and is the #1 cause of non-traumatic disability in...
Collaborative Research: Role of soil microbiome resilience in ecosystem recovery following severe wildfire
Wildfire is a natural feature of healthy forest ecosystems. There is concern because the frequency and intensity of these events are increasing as our climate warms. Among their ma...
Flexible normalization in ferret V1: computational modeling and 2-photon imaging
ABSTRACT The remarkable efficiency of human perception derives from the fact that we do not process each stimulus as a novel event. Instead, past experiences and scene context info...
Midlife Obesity, Neurovascular Senescence and Cognitive Decline
Stefano Tarantini, PhD, is a junior aging researcher whose overarching goal is to develop an independent research program to understand and apply nutritional lifestyle intervention...
Elucidating dietary fructose and alcohol interactions during liver cancer development
Project Summary/Abstract Hepatocellular carcinoma (HCC) has been alarmingly increased, in part due to rapid increases in fatty liver disease. Owing to the lack of early diagnostic...
Investigation of Sirt1 activation to target IDH mutant glioma
Project Summary IDH mutant gliomas are incurable, primary brain tumors that affect young to middle-aged adults and are defined by a mutation in a key metabolic gene. Despite treatm...
Opioid Prescribing and Chronic Pain in the Primary Care Setting
Project Summary/Abstract Amidst high levels of chronic pain, the United States (U.S.) has seen a concurrent opioid overdose epidemic that has led to the deaths of an estimated 702,...
Resolving the Hierarchy and Regulation of Sebaceous Gland Stem Cells
PROJECT SUMMARY Sebaceous glands (SGs) are appendages of mammalian skin that produce and secrete a mixture of lipids, known as sebum. Sebum production is crucial for skin maintenan...
Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methods
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects approximately 1 million people in the US and is the #1 cause of non-traumatic disability in...
Minimizing Hypoglycemia in Adults with Type 1 Diabetes through an Integrated Mobile Health and Continuous Glucose Monitoring System
Project Summary / Abstract Level 2 hypoglycemia (blood glucose
Cell-cell communication mediated by fluid flows
Project Summary Cells can detect external fluid flows across their surface. Such flows, and the flow signaling events they induce, are critical for organ development, homeostasis,...
Investigation of Sirt1 activation to target IDH mutant glioma
Project Summary IDH mutant gliomas are incurable, primary brain tumors that affect young to middle-aged adults and are defined by a mutation in a key metabolic gene. Despite treatm...
Genetic Contributors to White Matter Microstructure in Aging and Alzheimers Disease
PROJECT SUMMARY While reductions in medial temporal lobe (MTL) white matter tract microstructure have been suggested to have a central role in longitudinal cognitive decline in agi...
Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression Risk
PROJECT ABSTRACT One in five adolescents in the United States will experience a depressive episode before age 18. Early prevention could offset a lifetime of morbidity including wo...
Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway
PROJECT SUMMARY/ABSTRACT An estimated 10% of Americans suffer from autoimmune disease, and the vast majority of those affected are women. This application proposes a five-year ment...
Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methods
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects approximately 1 million people in the US and is the #1 cause of non-traumatic disability in...