Results for Environment
40,772 grants found
Showing 35,121 – 35,140 of 40,772 grants for "Environment"
Reduced thioredoxin in both the cytosol and mitochondria: a key modulator of age-related cancer development in Trx1KO x Trx2KO mice?
This proposal is prompted by our observation that the down-regulation of thioredoxin (Trx) in both the cytosol and mitochondria (Trx1KO x Trx2KO) in mice resulted in reduced sponta...
Integrating GPS, GIS, and Ecological Momentary Assessment to Determine the Effect of Home and Neighborhood Context on Adolescent Sleep
Project Summary/Abstract Insufficient sleep doubles the risk of obesity among youth and increases the risk of cardiovascular disease (CVD) in adulthood. Over 75% of US high school...
Suicide Clusters in Schools and Communities
SUMMARY The goal of this proposed project is to determine how social environments in schools and communities generate – or ameliorate – vulnerability to youth suicide and suicide c...
Defining a common mechanism of SAMHD1 function in cancer, HIV, and AGS
Project Summary As of 2019 there were 38.0 million individuals living with HIV globally. This number continues to rise yearly despite advances in HIV treatment. A significant chall...
Long-term Trauma Outcomes and Insurance Policy
PROJECT SUMMARY/ABSTRACT Though trauma is often considered an isolated disease process, advancements in acute care have shifted the burden of injury from the acute physiologic insu...
Ciliary melanin concentrating hormone receptors and the link to cognitive dysfunction in mice
Project Abstract The hypothalamic neuropeptide melanin-concentrating hormone (MCH) is a cyclic peptide expressed almost exclusively in the lateral hypothalamus (LH) and zona incert...
Decoding temporal epithelial signaling programs to restore homeostasis in acute lung injury
Abstract Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common pulmonary syndrome with high mortality. ALI/ARDS stems from a communication breakdown between...
Ataxia Telangiectasia Mutated (ATM)-mediated hepatic DNA damage in pediatric nonalcoholic fatty liver disease
Pediatric nonalcoholic fatty liver disease (PNAFLD) is the leading cause of chronic liver disease in childhood. Progression from fatty liver (FL) to steatohepatitis (NASH) signific...
The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
On the sporadic Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (sALS/FTD) clinical spectrum, the aggregation and accumulation of disease-associated proteins such as TDP-43 i...
Compound Cardiovascular Activity Prediction Using Structural and Genomic Features
Project Summary Unexpected cardiovascular activity plays a substantial role in therapeutic program failure leading to major loss of patient life and research time. Therefore, it is...
What is the role of blood-brain-barrier regional specificity in the nucleus accumbens?
PROJECT SUMMARY/ABSTRACT The blood-brain barrier (BBB) is a term that describes the unique properties of central nervous system (CNS) blood vessels which allow them to stringently...
Effect of right-ventricular structural remodeling during pressure overload on the mechanical behavior of myofibers in excised human myocardium
ABSTRACT Chronic pressure overload in the right ventricle (RV), such as that experienced in pulmonary hypertension (PH), leads to structural remodeling of the myocardium as the RV...
Real-Time Bronchoscope Localization Using Machine Learning To Improve Lung Cancer Diagnosis
Project Summary/Abstract Lung cancer 5-year survival rates drop from 61% for early stage diagnosis to just 6% for late stage diagnosis. Currently, fewer than 1 in 5 cases are diagn...
Modulation of ribosome velocity as a means to rescue refractory CF-causing variants
PROJECT SUMMARY (ABSTRACT) Cystic fibrosis (CF) is a lethal autosomal recessive disorder caused by mutation of the CF transmembrane conductance regulator (CFTR).The majority of CF...
Collagen Oxidation, Myofibroblast Activation and Age-Associated Pulmonary Fibrosis
PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease characterized by scarred lung tissue containing excessive extracellular matrix (ECM).Chang...
Translation of epidemiologic findings in enteric disease to public health action
PROJECT SUMMARY/ABSTRACT Epidemiologic studies are critical for understanding the diverse drivers of enteric infections and malnutrition, which lead to recurrent diarrheal illnesse...
Enhanced Dementia Instruction and Tool in Home Hospice Care (EDITH-HC)
PROJECT SUMMARY/ABSTRACT The long-term objective of this K99/R00 application is to develop Dr.Elizabeth Luth?s capacity to conduct studies aimed at reducing caregiver burden and im...
Translation of epidemiologic findings in enteric disease to public health action
PROJECT SUMMARY/ABSTRACT Epidemiologic studies are critical for understanding the diverse drivers of enteric infections and malnutrition, which lead to recurrent diarrheal illnesse...
Neuro-computational mechanisms of social learning and variation along psychiatric symptom dimensions and in autism
PROJECT SUMMARY Social learning is key for acquiring knowledge about the world and for deciding how to act in social situations. By allowing individuals to learn the consequences o...
Synaptic and cellular mechanisms of neuronal synchronization
Project Summary/Abstract Neuronal activity must be precisely coordinated to provide an accurate representation of our environment, a feature exemplified by the electrical patterns...