Results for Environment
40,772 grants found
Showing 35,101 – 35,120 of 40,772 grants for "Environment"
The Roles of a Novel Microprotein in Wound Healing and Cancer
Project Summary The pathways that regulate processes necessary for wound healing, such as proliferation and migration, are often co-opted by tumors, leading to their description as...
Early life adversity amplifies behavioral opportunism by altering striatal dopamine signaling
PROJECT SUMMARY Early life adversity (ELA) is associated with a significant increase in risk for substance use disorder. However, themechanisms by which ELA increases the risk for...
Group 1 Metabotropic Glutamate Receptor’s Influence on T Cells During Chronic Toxoplasma Infection
PROJECT SUMMARY/ABSTRACT Toxoplasma gondii (T. gondii) is one of the most effective transmissible pathogens in the world, infecting approximately two billion people. Encystment of...
Processing of TGFbeta as a mechanism for precise temporal orchestration in long term memory formation
PROJECT SUMMARY One of the great challenges of modern neuroscience is understanding the detailed molecular choreography required for the formation of lasting memories in the brain....
Injectable Fibrous Scaffolds for Meniscal Repair
Project Summary/Abstract The meniscus is an important load-bearing structure that protects the underlying articular cartilage and thus reduces the incidence of osteoarthritis (OA)....
Effect of right-ventricular structural remodeling during pressure overload on the mechanical behavior of myofibers in excised human myocardium
ABSTRACT Chronic pressure overload in the right ventricle (RV), such as that experienced in pulmonary hypertension (PH), leads to structural remodeling of the myocardium as the RV...
Compound Cardiovascular Activity Prediction Using Structural and Genomic Features
Project Summary Unexpected cardiovascular activity plays a substantial role in therapeutic program failure leading to major loss of patient life and research time. Therefore, it is...
Intraflagellar transport process in primary cilium maintenance
PROJECT SUMMARY Primary cilia are non-motile antenna-like sensors that protrude into extracellular space for detecting a wide range of signals, including signals for cell prolifera...
Suicide Clusters in Schools and Communities
SUMMARY The goal of this proposed project is to determine how social environments in schools and communities generate – or ameliorate – vulnerability to youth suicide and suicide c...
Function and regulation of constitutive protein translation in platelets
Project Summary The goals of this proposal are: 1) to elucidate the molecular signaling of protein translation initiation in circulating human platelets and characterize the plasma...
What is the role of blood-brain-barrier regional specificity in the nucleus accumbens?
PROJECT SUMMARY/ABSTRACT The blood-brain barrier (BBB) is a term that describes the unique properties of central nervous system (CNS) blood vessels which allow them to stringently...
South Texas Alzheimer's Disease Center Administrative Core
PROJECT SUMMARY/ABSTRACT – Administrative Core The South Texas Alzheimer’s Disease Center (STAC) Administrative Core (AC), part of the collaborative effort of University of Texas H...
South Texas Alzheimer's Disease Center Research and Education Core
The cost of dementia care in the US will be $1 Trillion by 2050. Moreover, this burden will be highest among minorities, a group that is itself diverse. The Hispanic/Latino populat...
Injectable Fibrous Scaffolds for Meniscal Repair
Project Summary/Abstract The meniscus is an important load-bearing structure that protects the underlying articular cartilage and thus reduces the incidence of osteoarthritis (OA)....
Neural control of coordinated eye movements
Project Summary / Abstract We look between targets located in the 3D visual environment by making disjunctive saccades that bring the target image onto both foveae. Each gaze shift...
Real-Time Bronchoscope Localization Using Machine Learning To Improve Lung Cancer Diagnosis
Project Summary/Abstract Lung cancer 5-year survival rates drop from 61% for early stage diagnosis to just 6% for late stage diagnosis. Currently, fewer than 1 in 5 cases are diagn...
The physical biology of neurodegeneration in sporadic Amyotrophic Lateral Sclerosis/Frontotemporal dementia
On the sporadic Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (sALS/FTD) clinical spectrum, the aggregation and accumulation of disease-associated proteins such as TDP-43 i...
Neural control of coordinated eye movements
Project Summary / Abstract We look between targets located in the 3D visual environment by making disjunctive saccades that bring the target image onto both foveae. Each gaze shift...
Screening for Cognitive Impairment Following Critical Illness: Designing and Testing an Implementation Program to Support High Risk Older Adults
Palakshappa 1K23AG073529-01Critical illness leads to incident mild cognitive impairment (MCI) or Alzheimer’s disease and related dementias (ADRD) in many older adults. Roughly 2.5...
Development of a Training Intervention to Improve Mental Health Treatment for Gender Minority Youth
PROJECT SUMMARY/ABSTRACT Background: Gender minority youth (GMY; children, adolescents, and young adults whose gender identity differs fromtheir birth-assigned sex) face a dispropo...