Results for Environment
40,772 grants found
Showing 35,041 – 35,060 of 40,772 grants for "Environment"
The Impact of Donor Hematopoietic DNMT3A Mutations in Stem Cell Transplant Recipients
PROJECT SUMMARY/ABSTRACT Hematopoietic cell transplant (HCT) is an important treatment modality for patients with hematologic malignancy (HM).Its success depends on the ability of...
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation
ABSTRACT We propose to develop novel neurorecording devices using sequential thin-film transistors that are capable of recording and stimulating brain activity with thousands of ch...
Decoding temporal epithelial signaling programs to restore homeostasis in acute lung injury
Abstract Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common pulmonary syndrome with high mortality.ALI/ARDS stems from a communication breakdown between l...
Integrating GPS, GIS, and Ecological Momentary Assessment to Determine the Effect of Home and Neighborhood Context on Adolescent Sleep
Project Summary/Abstract Insufficient sleep doubles the risk of obesity among youth and increases the risk of cardiovascular disease (CVD) in adulthood. Over 75% of US high school...
Driving Pressure as a Target for Lung-Protective Ventilation
PROJECT SUMMARY/ABSTRACT Sarina Sahetya, MD MHS is a pulmonary and critical care physician-scientist at Johns Hopkins University, with a Master?s degree in Clinical Investigation.T...
Enteroendocrine Regulation of Intestinal Metabolism
PROJECT SUMMARY Dr. Heather McCauley is mentored by Dr.James Wells at Cincinnati Children?s Hospital Medical Center (CCHMC), the largest pediatric research institution in the natio...
The contribution of late onset unexplained epilepsy to cognitive decline and its interaction with vascular and Alzheimer's disease pathologies
Project Summary As life expectancy increases, the burden of seizures in the elderly will increase with up to half of the cases with no identifiable cause termed Late Onset Unexplai...
Ataxia Telangiectasia Mutated (ATM)-mediated hepatic DNA damage in pediatric nonalcoholic fatty liver disease
Pediatric nonalcoholic fatty liver disease (PNAFLD) is the leading cause of chronic liver disease in childhood.Progression from fatty liver (FL) to steatohepatitis (NASH) significa...
Injectable Fibrous Scaffolds for Meniscal Repair
Project Summary/Abstract The meniscus is an important load-bearing structure that protects the underlying articular cartilage and thus reduces the incidence of osteoarthritis (OA)....
Mechanisms of skin commensal colonization resistance against opportunistic Staphylococci
PROJECT SUMMARY Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) on healthy skin.Evidence suggests that CoNS actively shape the skin immu...
Group 1 Metabotropic Glutamate Receptor’s Influence on T Cells During Chronic Toxoplasma Infection
PROJECT SUMMARY/ABSTRACT Toxoplasma gondii (T. gondii) is one of the most effective transmissible pathogens in the world, infecting approximately two billion people. Encystment of...
Early life adversity amplifies behavioral opportunism by altering striatal dopamine signaling
PROJECT SUMMARY Early life adversity (ELA) is associated with a significant increase in risk for substance use disorder. However, the mechanisms by which ELA increases the risk for...
Developing new tools to probe membrane protein-lipid interactions for biomedical applications
Integral membrane proteins reside in the biological membrane where they function and intimately interact with lipid molecules. The environment of the biological membrane is dynamic...
Neural control of coordinated eye movements
Project Summary / Abstract We look between targets located in the 3D visual environment by making disjunctive saccades that bring the target image onto both foveae.Each gaze shift...
Reduced thioredoxin in both the cytosol and mitochondria: a key modulator of age-related cancer development in Trx1KO x Trx2KO mice?
This proposal is prompted by our observation that the down-regulation of thioredoxin (Trx) in both the cytosol and mitochondria (Trx1KO x Trx2KO) in mice resulted in reduced sponta...
Childhood fluoride exposure and sleep patterns
PROJECT SUMMARY I am a clinical psychologist interested in understanding the role of environmental exposures in neuro-endocrine development.The goal of this proposal is to receive...
The Roles of a Novel Microprotein in Wound Healing and Cancer
Project Summary The pathways that regulate processes necessary for wound healing, such as proliferation and migration, are often co-opted by tumors, leading to their description as...
Assessing Ligand vs Ligandless Catalysis to Simplify Chemical Transformations and Drug Discovery
PROJECT SUMMARY The detection of new microbe strains together with drug resistant bacteria require innovative advances in chemical synthesis and biology to ensure prompt developmen...
Processing of TGFbeta as a mechanism for precise temporal orchestration in long term memory formation
PROJECT SUMMARY One of the great challenges of modern neuroscience is understanding the detailed molecular choreography required for the formation of lasting memories in the brain....
Identification of genetic modifiers of GATA6 in human congenital heart diseases
PROJECT SUMMARY Outflow tract (OFT) anomalies comprise more than 30% of congenital heart diseases (CHD) and are life- threatening in the absence of surgical interventions.GATA6 het...