Results for Environment
40,772 grants found
Showing 35,001 – 35,020 of 40,772 grants for "Environment"
The Contribution of Omic Profiles to Weight Loss and Obesity
PROJECT SUMMARY The development of cardiovascular disease (CVD) is a complex process, with obesity being a major risk factor. Weight loss among overweight/obese individuals is a ke...
The role of Rpl5 haploinsufficiency in hematopoietic stem/progenitor cell function in Diamond Blackfan anemia
PROJECT SUMMARY/ABSTRACT Anemia is an extraordinarily common condition that affects approximately 1 in 3 people around the globe. Erythropoiesis is exquisitely sensitive to both en...
Pathologic Substrates of Neuropsychiatric Symptoms in Aphasic Dementia
PROJECT SUMMARY. The increasing prevalence of dementia worldwide is considered a looming public healthcrisis, and few effective treatments are available to alleviate patients’ cogn...
Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson disease
Parkinson disease (PD) is the second most common progressive neurodegenerative disorder characterized by tremendous clinical heterogeneity. PD with dementia is considered one of th...
A Preconception Health Intervention to Reduce Substance Exposed Pregnancies among Incarcerated Women
PROJECT SUMMARY The devastating effects of illicit substance use during pregnancy on mothers and children is widespread, affecting more than 500,000 births between 2017 and 2018. A...
CAREER: Crystallization of Chiral Liquid Crystals Under Curved Confinement
This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). NON-TECHNICAL ABSTRACTLiquid crystals, with properties between conventional...
CAREER: Computational tools for analyzing and interpreting DNA methylation
This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).DNA methylation is a critical biological process that plays such an important...
Investigations Into Dynamic DNA Recognition and Processing During Eukaryotic Nucleotide Excision Repair
DNA undergoes continuous damage from endogenous and environmental sources. Unrepaired DNA damage interferes with cellular functions such as replication and transcription, often res...
CAREER: Backyard Evolution across a Seasonal Metapopulation in Drosophila
This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).This project will further our understanding of how evolution happens when the...
CAREER: Examining bacterial filamentation as a mechanism for cell-to-cell spreading in an animal host
This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).Bacterial pathogens pose a continuing threat to health and agriculture, and a...
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
Abstract Despite major gains in smoking cessation treatment, over half of recently quit smokers will relapse within the first year. Two systematic reviews of relapse prevention stu...
CAREER: Making Smart Hospital Rooms Useful
Integrating smart home technology into hospital patient rooms should make hospitals more efficient, improve patient recovery and rehabilitation, and enhance the experience of being...
A deep learning framework for high-definition prediction and interpretation of protein localization
Proteins are molecules that perform diverse functions in various cell compartments and subcellular organelles. Aberrant localization of proteins may lead to harmful effects on cell...
Identifying Differential Psychosocial and Neurobiological Risk Factors of the Transition from Acute to Chronic Pain in Black and Non-Hispanic White Adults
Abstract Low back pain affects an estimated 65 million individuals in the United States, and Black Americans are disproportionately affected by the detrimental consequences of pain...
Identifying Differential Psychosocial and Neurobiological Risk Factors of the Transition from Acute to Chronic Pain in Black and Non-Hispanic White Adults
Abstract Low back pain affects an estimated 65 million individuals in the United States, and Black Americans are disproportionately affected by the detrimental consequences of pain...
Maternal Stress Resilience During Pregnancy and Offspring Emotion Regulation
PROJECT SUMMARY/ABSTRACT Evidence shows that maternal stress exposure during pregnancy can have enduring effects on offspring emotion regulation (ER), a transdiagnostic factor unde...
Biostatistics and Bioinformatics Core
Project Summary – Bioinformatics and Biostatistics Core C The Biostatistics Core has been an integral part of the first Wistar/UPenn SPORE in Skin Cancer (2001-2009; 2014-2019). Co...
Data science tools to identify robust exposure-phenotype associations for precision medicine
Project Summary/Abstract Phenotypic variability across demographically diverse populations are driven by environmental factors.The overall goal of this proposal is to deploy data s...
Impact of clonal hematopoiesis mutations on toxicity and outcomes following oncologic therapy
PROJECT SUMMARY Studies in healthy individuals have shown that acquired DNA mutations are surprisingly common in normal- appearing tissues. Clonal hematopoiesis (CH) mutations are...
Predicting and Preventing Suicidal Ideation among High-Risk Sexual and Gender Minority Adolescents
PROJECT SUMMARY Sexual and gender minority (SGM) adolescents are at increased risk for suicide. Approximately 1 in 3 SGM adolescents report having attempted suicide compared to 1 i...