Results for Environment
40,772 grants found
Showing 34,981 – 35,000 of 40,772 grants for "Environment"
Mechanobiology of Cardiac Outflow Tract Morphogenesis
Proper growth, septation, and maturation of the cardiac outflow tract (OFT) into valved aortic and pulmonary outlets are essential for oxygenated circulation after birth. 1-2% of l...
Exosome treatment-induced mechanisms in chronic wound beds - Resubmission - 1
PROJECT SUMMARY Chronic wounds present a costly social and medical dilemma, particularly in patients with type II diabetes, but there are no effective treatments. These wounds are...
Dissecting the roles of type 2 diabetes-associated variants and effector genes in islet endoplasmic reticulum stress response
PROJECT SUMMARY Type 2 Diabetes (T2D) is a complex disease caused by both genetic and environmental factors. Genome-wide association studies (GWAS) have identified 403 association...
Testing a Multilevel, Multicomponent, Multigenerational Dietary Intervention to Improve Southeast Asian Children's Diets
Background. Poor diet quality is a significant and critical problem for Southeast Asian (SEA) children whose families came to the US as refugees [e.g., Hmong, Cambodian, Laotian, V...
Testing a Multilevel, Multicomponent, Multigenerational Dietary Intervention to Improve Southeast Asian Children's Diets
Background. Poor diet quality is a significant and critical problem for Southeast Asian (SEA) children whose families came to the US as refugees [e.g., Hmong, Cambodian, Laotian, V...
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapy
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a notorious malignancy with no change to the dismal survival rate. Surgery is still the first option where most tumors ar...
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapy
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a notorious malignancy with no change to the dismal survival rate. Surgery is still the first option where most tumors ar...
Molecular Regulators of Synaptic Specificity
Project Summary Specific circuits in the brain determine how we sense and respond to our environment. These highly connected networks emerge during development as neurons extend pr...
A Preconception Health Intervention to Reduce Substance Exposed Pregnancies among Incarcerated Women
PROJECT SUMMARY The devastating effects of illicit substance use during pregnancy on mothers and children is widespread, affecting more than 500,000 births between 2017 and 2018. A...
The Contribution of Omic Profiles to Weight Loss and Obesity
PROJECT SUMMARY The development of cardiovascular disease (CVD) is a complex process, with obesity being a major risk factor. Weight loss among overweight/obese individuals is a ke...
Investigation of cerebrovascular Notch as a novel modulator of cognitive function
Project Summary Alzheimer’s disease (AD) afflicts over 6 million people in the United States, and this number is expected to climb to nearly 13 million by 2050. The development of...
Investigating a role for dopamine in organizing behavioral sequencing
Abstract The brain assesses the environment, makes decisions, and turns decisions into behavior. Behavior, or the total outward movement displayed by an organism, is constructed by...
Pathologic Substrates of Neuropsychiatric Symptoms in Aphasic Dementia
PROJECT SUMMARY. The increasing prevalence of dementia worldwide is considered a looming public healthcrisis, and few effective treatments are available to alleviate patients’ cogn...
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
Abstract Despite major gains in smoking cessation treatment, over half of recently quit smokers will relapse within the first year. Two systematic reviews of relapse prevention stu...
Maternal Stress Resilience During Pregnancy and Offspring Emotion Regulation
PROJECT SUMMARY/ABSTRACT Evidence shows that maternal stress exposure during pregnancy can have enduring effects on offspring emotion regulation (ER), a transdiagnostic factor unde...
Investigating a Role for Dopamine in Organizing Behavioral Sequencing
Abstract The brain assesses the environment, makes decisions, and turns decisions into behavior. Behavior, or the total outward movement displayed by an organism, is constructed by...
Investigation of cerebrovascular Notch as a novel modulator of cognitive function
Project Summary Alzheimer’s disease (AD) afflicts over 6 million people in the United States, and this number is expected to climb to nearly 13 million by 2050. The development of...
Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTD
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two of the costliest and most devastating neurodegenerative diseases. An estimated 16,000 America...
Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTD
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two of the costliest and most devastating neurodegenerative diseases. An estimated 16,000 America...
Supplement: Design and Model-Based Safety Verification of a Volitional Sit-Stand Controller for a Powered Knee-Ankle Prosthesis
Childcare supplement request for 1-F31-EB-032745-01. The information below is for the original submission. ABSTRACT Sit-stand transitions, the motions executed by individuals to st...