Results for Environment
40,772 grants found
Showing 34,921 – 34,940 of 40,772 grants for "Environment"
Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy
PROJECT SUMMARY Candidate. Krishna G. Aragam, MD MS is a board-certified physician in internal medicine and cardiology at Massachusetts General Hospital (MGH), an Instructor in Med...
teleABLE: Adapting a Behavioral Activation-Based Intervention to Reduce Post-Stroke Sedentary Behavior Using Telehealth
PROJECT SUMMARY/ABSTRACT This K23 application proposes a career development plan to help Dr. Emily Kringle establish an independent research program that focuses on optimizing heal...
An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection
Project Summary Cutting-edge technologies are generating large datasets across biological processes, including those following viral infection and host responses. However, lack of...
A pan-cancer atlas of driver mutations in >100,000 patients based on a hypothesis-driven combined computational and experimental approach
PROJECT SUMMARY Most mutations in cancer genomes are random passengers that do not contribute to oncogenesis, whereas only a few are drivers critical for tumor development. Existin...
Tracking, elucidation and modulation of xenometal homeostasis in bacteria
Bacterial virulence is closely associated with nutrient acquisition, which is essential for growth and proliferation of pathogens.Metal ions constitute essential nutrients, and the...
New approaches to the pathophysiology, diagnosis and management of heparin-induced thrombocytopenia
PROJECT SUMMARY/ABSTRACT Heparin-induced thrombocytopenia (HIT) is a severe, antibody (ab)-mediated prothrombotic syndrome with high morbidity and mortality.The biochemical basis o...
Outreach, Recruitment and Engagement Core
PROJECT SUMMARY ?Outreach Recruitment and Engagement Core (OREC) Increased prevalence of dementia in African American and Hispanic communities compounds the disproportionate econom...
Opioid Dose Reduction in Comprehensive Inpatient Rehabilitation: A pharmaco-behavioral approach
PROJECT SUMMARY This K23 career development award will position the candidate to become an independent clinical researcher with expertise in refining and testing pharmaco-behaviora...
Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy
PROJECT SUMMARY Candidate. Krishna G.Aragam, MD MS is a board-certified physician in internal medicine and cardiology at Massachusetts General Hospital (MGH), an Instructor in Medi...
An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection
Project Summary Cutting-edge technologies are generating large datasets across biological processes, including those following viral infection and host responses. However, lack of...
New approaches to the pathophysiology, diagnosis and management of heparin-induced thrombocytopenia
PROJECT SUMMARY/ABSTRACT Heparin-induced thrombocytopenia (HIT) is a severe, antibody (ab)-mediated prothrombotic syndrome with high morbidity and mortality. The biochemical basis...
Outreach, Recruitment and Engagement Core
PROJECT SUMMARY – Outreach Recruitment and Engagement Core (OREC) Increased prevalence of dementia in African American and Hispanic communities compounds the disproportionate econo...
An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection
Project Summary Cutting-edge technologies are generating large datasets across biological processes, including those following viral infection and host responses.However, lack of c...
Role of arginine-vasopressin and V1A receptor in psychosocial stress-induced myocardial injury
PROJECT SUMMARY/ABSTRACT Heart disease is the leading cause of death in the United States and together with cerebrovascular diseases account for over 28% of total deaths in the Uni...
Outreach, Recruitment and Engagement Core
PROJECT SUMMARY – Outreach Recruitment and Engagement Core (OREC) Increased prevalence of dementia in African American and Hispanic communities compounds the disproportionate econo...
Penn Alzheimer's Disease Research Center (ADRC)
Penn ADRC Overall Project Summary The mission of the University of Pennsylvania?s Alzheimer?s Disease Research Center (Penn ADRC) is to increase research and education on Alzheimer...
teleABLE: Adapting a Behavioral Activation-Based Intervention to Reduce Post-Stroke Sedentary Behavior Using Telehealth
PROJECT SUMMARY/ABSTRACT This K23 application proposes a career development plan to help Dr.Emily Kringle establish an independent research program that focuses on optimizing healt...
Early Intervention to Promote Cardiovascular Health of Mothers and Children in Northern Appalachia
PROJECT SUMMARY/ABSTRACT As part of NHLBI’s ENRICH program, this research will test an implementation-ready intervention designed to improve cardiovascular health (CVH) among high...
Healthy Hearts/ Corazones Saludables: Partnership to promote cardiovascular health in Hispanic and non-Hispanic mothers and children in US home visiting programs
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in US women, accounting for approximately one of every three female deaths. Obesity is arguably...
The role of ubiquitin in GPCR signaling
ABSTRACT The G protein-coupled receptor (GPCR) C-X-C chemokine receptor 4 (CXCR4) and its cognate ligand CXCL12 have been linked to endothelial cell migration, a necessary part of...