Results for Environment
40,772 grants found
Showing 34,781 – 34,800 of 40,772 grants for "Environment"
The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly
PROJECT SUMMARY Cancer continues to be a leading cause of death worldwide. Despite significant efforts devoted towards developing effective treatments, the survival rates remain lo...
Diabetes Mellitus Promotes Breast Tumor Progression via Glycation Mediated Matrix Stiffening
PROJECT SUMMARY/ABSTRACT Diabetes mellitus is a complex disease associated with hyperglycemia. A growing body of epidemiological evidence supports that patients with comorbidity of...
Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidney
PROJECT SUMMARY/ABSTRACT This NIH Mentored Career Development Award describes a three-year proposal providing the training and mentorship necessary for the candidate to develop int...
Light-Activated Silver Nanoparticles to Eliminate Antibiotic Resistant Bacteria and Genes
Abstract The development of microbial resistance to antimicrobial agents is one of the biggest public health issues of the 21st century. Antibiotic-resistant bacteria (ARB) cause m...
A Superiority Trial of Radiofrequency Ablation for Low Back Pain (ASTRAL)
Low back pain is the #1 contributor to years lived with disability, driven mainly by chronic low back pain (CLBP; pain lasting ≥3 months). An obstacle to reducing the societal burd...
Effects of household concrete floors on child health
PROJECT SUMMARY Soil-transmitted helminth infections and diarrhea are responsible for a large burden of morbidity and mortality among children under 5-years and are associated with...
Impact of the ESRD Treatment Choices Model on Home Dialysis Uptake and Disparities
PROJECT SUMMARY/ABSTRACT Dr. Sri Lekha Tummalapalli is a nephrologist and health services researcher whose long-term goal is to become a leading national expert studying healthcare...
Pandemic preparedness in schools: A community based approach for sentinel surveillance
PROJECT SUMMARY The COVID-19 pandemic prompted governments to implement a range of public health measures, including school closures, to slow the spread of SARS-CoV-2. However, the...
AI-Aided Tool for Day Zero Selection of High Performing Cells for Biopharma Cell Line Development
SUMMARY With the increasing number of protein therapeutic candidates, identifying and isolating single-cell derived colonies is a critical step that is conducted routinely and freq...
Validation of a pediatric thrombosis risk assessment model and characterization of bleeding in hospitalized children through the Children's Hospital Acquired Thrombosis (CHAT) Consortium
PROJECT SUMMARY/ABSTRACT Venous thromboembolism (VTE), a serious and life-threatening condition, has increased in incidence for hospitalized pediatric patients by 70-200%. This has...
Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease
Project Summary/Abstract Intestinal immune responses are linked to the trillions of microorganisms that colonize the gastrointestinal tract. Thus, inter-individual variations in th...
Dissecting the cellular interplays of adipose tissue remodeling in the regulation of insulin sensitivity
PROJECT SUMMARY/ABSTRACT This proposed career development award will provide Dr. Diana Alba MD with targeted mentored training to ensure she develops into an independent researcher...
Outcomes and perspectives on treatment for critical limb ischemia in patients with end-stage renal disease
Project Summary/Abstract Amputation and mortality rates are extraordinarily high for patients living with both advanced peripheral arterial disease, or critical limb ischemia (CLI)...
Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
PROJECT SUMMARY/ABSTRACT This application for a K01 Mentored Research Scientist Award is submitted by Xiaojuan Li, PhD in response to PA-20-190. Dr. Li is a pharmacoepidemiologist...
Genomic Instability from Fragmented Chromosomes in Micronuclei
Project Summary/Abstract Abnormal chromosomes are hallmark features of human diseases and genetic disorders. Cancer genome sequencing has uncovered a complex class of localized gen...
Excellence in Research: Structure and Dynamics of Exciplexes in Thermally Activated Delayed Fluorescence
In this project, jointly funded by the Office of Integrative Activities (OIA), the Chemical Structure, Dynamics, and Mechanisms-A (CSDM-A) program in the Division of Chemistry, and...
Collaborative Research: PlantSynBio: Deciphering the roles of genetic and biochemical redundancy and pathway regulation via refactoring the protective plant cuticle
As stationary organisms that are faced with surviving constantly changing environments, plants have evolved specialized features to protect against environmental stresses. One of t...
Collaborative Research: AGS-FIRP Track 2: Lake-Effect Electrification (LEE) and the Impacts of Wind Turbines on Electrification East of Lake Ontario
The Lake-Effect Electrification (LEE) Project will occur between September and March 2022-23 focused on Lake Ontario and the downwind (east of the lake) region of upstate New York....
Collaborative Research: PlantSynBio: Deciphering the roles of genetic and biochemical redundancy and pathway regulation via refactoring the protective plant cuticle
As stationary organisms that are faced with surviving constantly changing environments, plants have evolved specialized features to protect against environmental stresses. One of t...
CAS: Harvesting Carbon Resources Locked in PVC and Polybutadiene Waste
With the support of the Macromolecular, Supramolecular, and Nanochemistry Program in the Division of Chemistry, Professor Rebecca Braslau of the University of California – Santa Cr...