Results for Environment
40,772 grants found
Showing 34,641 – 34,660 of 40,772 grants for "Environment"
Data science tools to identify robust exposure-phenotype associations for precision medicine
Project Summary/Abstract Phenotypic variability across demographically diverse populations are driven by environmental factors. The overall goal of this proposal is to deploy data...
Data science tools to identify robust exposure-phenotype associations for precision medicine
Project Summary/Abstract Phenotypic variability across demographically diverse populations are driven by environmental factors. The overall goal of this proposal is to deploy data...
Impact of clonal hematopoiesis mutations on toxicity and outcomes following oncologic therapy
PROJECT SUMMARY Studies in healthy individuals have shown that acquired DNA mutations are surprisingly common in normal- appearing tissues. Clonal hematopoiesis (CH) mutations are...
Predicting and Preventing Suicidal Ideation among High-Risk Sexual and Gender Minority Adolescents
PROJECT SUMMARY Sexual and gender minority (SGM) adolescents are at increased risk for suicide. Approximately 1 in 3 SGM adolescents report having attempted suicide compared to 1 i...
Data science tools to identify robust exposure-phenotype associations for precision medicine
Project Summary/Abstract Phenotypic variability across demographically diverse populations are driven by environmental factors. The overall goal of this proposal is to deploy data...
Genetics of adaptation to toxic environments
SUMMARY Resistance to toxins often evolves via major effect mutations in the target protein.Theory predicts that these major effect mutations carry fitness costs, which are subsequ...
Mediating Role of Gut Microbiota in the Regulation of Colorectal Cancer Risk in the Context of Time-restricted Eating and Calorie Restriction
PROJECT ABSTRACT The goal of this Diversity Supplement is to extend the significance and innovation of the Parent grant by examining the effect of time-restricted eating (TRE) and...
Data science tools to identify robust exposure-phenotype associations for precision medicine
Project Summary/Abstract Phenotypic variability across demographically diverse populations are driven by environmental factors. The overall goal of this proposal is to deploy data...
Biostatistics and Bioinformatics Core
Project Summary – Bioinformatics and Biostatistics Core C The Biostatistics Core has been an integral part of the first Wistar/UPenn SPORE in Skin Cancer (2001-2009; 2014-2019). Co...
Genetics of adaptation to toxic environments
SUMMARY Resistance to toxins often evolves via major effect mutations in the target protein. Theory predicts that these major effect mutations carry fitness costs, which are subseq...
Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy
PROJECT SUMMARY Candidate. Krishna G. Aragam, MD MS is a board-certified physician in internal medicine and cardiology at Massachusetts General Hospital (MGH), an Instructor in Med...
Outreach, Recruitment and Engagement Core
PROJECT SUMMARY – Outreach Recruitment and Engagement Core (OREC) Increased prevalence of dementia in African American and Hispanic communities compounds the disproportionate econo...
An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection
Project Summary Cutting-edge technologies are generating large datasets across biological processes, including those following viral infection and host responses. However, lack of...
teleABLE: Adapting a Behavioral Activation-Based Intervention to Reduce Post-Stroke Sedentary Behavior Using Telehealth
PROJECT SUMMARY/ABSTRACT This K23 application proposes a career development plan to help Dr. Emily Kringle establish an independent research program that focuses on optimizing heal...
New approaches to the pathophysiology, diagnosis and management of heparin-induced thrombocytopenia
PROJECT SUMMARY/ABSTRACT Heparin-induced thrombocytopenia (HIT) is a severe, antibody (ab)-mediated prothrombotic syndrome with high morbidity and mortality. The biochemical basis...
Role of arginine-vasopressin and V1A receptor in psychosocial stress-induced myocardial injury
PROJECT SUMMARY/ABSTRACT Heart disease is the leading cause of death in the United States and together with cerebrovascular diseases account for over 28% of total deaths in the Uni...
Quantitative Measurement of Wildfire Behavior in the Field: Leveraging Remote Sensing for Reproducible Observation and Improved Understanding
The increasing social, ecological and economic impact of wildfires in multiple regions of the world, including the western United States, has spurred research into fire behavior pr...
Belmont Forum Collaborative Research: Global Change Impact on Vulnerable Carbon Reservoirs: Carbon Sequestration and emissions in soils and waters from the Arctic to the Equator
This award provides support to U.S. researchers participating in a project competitively selected by a 9-country initiative on global change research through the Belmont Forum. The...
Belmont Forum Collaborative Research: Residual Risk of Extreme Floods: a challenge for achieving sustainable development goals
This award provides support to U.S. researchers participating in a project competitively selected by a 55-country initiative on global change research through the Belmont Forum. Th...
Seismic and Hydrostratigraphic Characterization of the Onshore-Offshore Freshwater Systems of Martha’s Vineyard and Nantucket, Massachusetts, USA
Coastal hydrological systems provide significant freshwater resources to coastal communities around the world. These resources are exploited by groundwater wells that produce from...