Results for Environment
40,772 grants found
Showing 34,541 – 34,560 of 40,772 grants for "Environment"
Multi-scale disease modeling of SCN2A-related epilepsy due to gain-of-function variants
Project Summary Epilepsy affects up to 1% of the population worldwide, and 3 million in the United States alone. A growing proportion of pediatric epilepsies are tied to causative...
TBI-induced adenosinergic dysregulation causes cognitive impairment and accelerates Alzheimer's disease pathology
Project Summary Epidemiological studies have revealed traumatic brain injury (TBI) as an important risk factor for development of Alzheimer’s disease (AD), a progressive neurodegen...
The trigger and homeostatic function of a novel immune-sebum circuit
PROJECT SUMMARY Sebum provides vital functions to the skin including moisture retention and defense against foreign inva- sion. Despite the well-defined immunologic function of seb...
Phenotypes of Muscle Loss in Smokers
PROJECT SUMMARY/ABSTRACT Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States and worldwide. Decreased muscle mass is common in COPD and as...
Determining the Involvement of PERK in TMAO Induced Atherosclerosis
ABSTRACT: The World Health Organization reports cardiovascular disease (CVD) as the global leading cause of death. Our long-term goal is to improve public health by advancing clini...
Spousal Influences on Subclinical and Clinical Vascular and Myocardial Disease
PROJECT SUMMARY/ABSTRACT: Project 4 (Lead: Patel; Early Stage Investigator) Spouse lifestyle choices and psychosocial characteristics may powerfully influence the other spouse’s ca...
Uganda Schistosomiasis Multidisciplinary Research Centre (U-SMRC)
SUMMARY Schistosomiasis is a major neglected tropical disease, estimated to affect 240 million people worldwide, leading to loss of a minimum of 1.9 million disability-adjusted lif...
Early Intervention to Promote Cardiovascular Health of Mothers and Children in Northern Appalachia
PROJECT SUMMARY/ABSTRACT As part of NHLBI’s ENRICH program, this research will test an implementation-ready intervention designed to improve cardiovascular health (CVH) among high...
Sensing active movement of the self: reconsidering the cellular basis kinesthesia
Abstract The sense of movement (kinesthesia) provides an interoceptive internal readout of our physical actions in space and is essential for our ability to move fluidly and effect...
Context-specific modulation of Clostridioides difficile virulence by Vancomycin-resistant Enterococcus faecium
Toxin expression and sporulation by Clostridioides difficile are context-specific phenomena that integrate signals from the surrounding environment including the local nutrient mil...
FASEB SRC: The Ubiquitin & Ub-like proteins Conference: Cell Functions and Therapeutic Targeting
Summary/Abstract The 2022 FASEB Summer Research Conference on Ubiquitin & Ub-like proteins: Cell Functions and Therapeutic Targeting will be held at the Southbridge Hotel and C...
Staphylococcus aureus and Pseudomonas aeruginosa interactions in wound pathogenesis
PROJECT ABSTRACT Patients with chronic wound infections have a rich microbial community and several bacterial species have been identified as the main drivers of persistent disease...
Integrative data science approaches for rare disease discovery in health records
ABSTRACT: There are nearly 7,000 diseases that have a prevalence of only one in 2,000 individuals or less. Yet, such rare diseases are estimated to collectively affect over 300 mil...
T cells in neurofibroma pathogenesis and malignanttransformation
PROJECT SUMMARY This proposal describes a five-year plan to prepare Steven Rhodes MD, PhD for independence as a physician scientist studying the immuno-oncologic interfaces of neur...
Development and comparison of multi-tissue and liver-specific epigenetic clock models to measure variation in biological aging in the rhesus macaque.
PROJECT SUMMARY While life expectancy in the United States has risen dramatically over the past several decades, the number of years spent free of major disease and disability (hea...
Network for Advancing Methodological Research in Longitudinal Studies of Aging
Longitudinal studies of the population near, through and after the retirement stage, such as the Health and Retirement Study (HRS), play an important role in aging research because...
Context-specific modulation of Clostridioides difficile virulence by Vancomycin-resistant Enterococcus faecium
Toxin expression and sporulation by Clostridioides difficile are context-specific phenomena that integrate signals from the surrounding environment including the local nutrient mil...
Addressing social adversity to improve outcomes among children undergoing liver transplant: the role for a health advocate on the transplant team
PROJECT SUMMARY . Pediatric liver transplantation is a life-saving procedure for children with end-stage liver disease, yet long-term outcomes remain sub-optimal. Children facing s...
Intergenerational Effects of Stress among Low-Income Pregnant Mothers & their Infants
PROJECT SUMMARY: As demonstrated by a growing number of studies, stress experienced during pregnancy can lead to significant long-term health problems for mothers and their infants...
The Hopkins Undergraduate Summer Training and Research (USTAR) Program
As the US undergoes a demographic transition to a larger and more racially and ethnically diverse older adult population, significant disparities in aging-related diseases will per...