Results for Environment
40,772 grants found
Showing 34,261 – 34,280 of 40,772 grants for "Environment"
Investigating the role of bromodomain-containing proteins in the production of viable spermatozoa and male fertility
Spermatogenesis is a highly unique differentiation process that involves complex mechanisms of gene regulation, particularly at the level of the transcriptional machinery. The comp...
CAREER: Science and Education for Connecting Urban Irrigation Efficiency to Streamflow in Semi-Arid Cities
Semi-arid U.S. cities are growing rapidly in regions where water is scarce. A major challenge for environmental sustainability is to help semi-arid communities thrive by ensuring t...
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology Preterm birth before 37th gestational week affects 1 of 10 infants and is an enormous...
Cytosolic Access and Instability of DNA nanoparticles
PROJECT SUMMARY/ABSTRACT: A number of candidate therapies such as CRISPR-Cas9 and gene silencing require the efficient delivery of functional nucleic acids to the cell cytosol and...
Bottom-Up Assembly of Functional Salivary Gland Tissues
Project Summary Despite advances in treatment strategies, xerostomia (or dry mouth) remains a permanent and devastating side effect of radiotherapy for head and neck cancers, reduc...
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology Preterm birth before 37th gestational week affects 1 of 10 infants and is an enormous...
Cargo Transport by Myosin Va and Kinesin-1 Molecular Motors: In Vitro Model Systems that Build Complexity in 3-Dimensions.
Project Summary/Abstract Intracellular cargo transport, such as lipid-bound insulin granules and presynaptic vesicles that are destined for secretion at the plasma membrane, rely o...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Equipment supplement - Refeyn TwoMP iSCAT microscope
Project Summary/Abstract Intracellular cargo transport, such as lipid-bound insulin granules and presynaptic vesicles that are destined for secretion at the plasma membrane, rely o...
Updating FishNet 2 to sustain its use in high-impact, global, ichthyological research
FishNet, and its successor, FishNet 2 (http://www.fishnet2.neT), have served the needs of researchers for quality data on fish specimens in research collections for the past 20-yea...
CAREER: Quantifying Radiation Belt Precipitation and Atmospheric Impacts through D-region Ionosphere Imaging
High energy particles from the Sun constantly bombard the Earth. Many are trapped by the Earth’s magnetic field in a region called radiation belt, which extends from an altitude of...
Small and medium enterprises' (SMEs) digital footprints and their ethical implications during the COVID-19 outbreak and beyond
The aim of this project is to help SMEs deal with the management of digital footprints that increased usage of digital tools is creating, especially after the Covid-19 outbreak. It...
Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.
Abstract Cells sense the extracellular environment primarily using G protein-coupled receptors (GPCRs).They represent the largest family of cell surface proteins and play key physi...
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disord...
Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors
Abstract The improvement in breast cancer survival is partially due to improvements in treatments. However, these treatments are not without mild to life-threatening side effects.F...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes.The tumor suppressor protein p53 is a transcription factor orchestrati...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10-years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and pre...
Regulation of Monocyte Entry to the Brain During Neuroinflammation
Project Summary Neuroinflammation can have both protective and detrimental outcomes in brain health, depending on the context. Immune cells that traffic to the brain may be critica...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres—which define and protect the ends of humans’ linear chromosomes—serve as a natural check on carcinogenesis. Genome stability requires cells to di...
Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors
Abstract The improvement in breast cancer survival is partially due to improvements in treatments. However, these treatments are not without mild to life-threatening side effects....