Results for Environment
40,772 grants found
Showing 34,241 – 34,260 of 40,772 grants for "Environment"
RAPID: Phosphorus Molecular Biogeochemistry during a Rapidly Changing Nutrient Load in Tampa Bay, FL
In late March 2021, a reservoir containing 500 million gallons of wastewater from a fertilizer production plant began leaking into nearby Tampa Bay, Florida, and then was drained i...
αvβ3-induced epithelial cancer progression via macrophage recruitment
Project Summary/Abstract It has recently become clear that carcinogenesis and cancer progression involves dysregulation of immune cells within the tumor microenvironment. The parti...
Structure and Regulatory Mechanisms of the Vacuolar ATPase
Project Summary Our laboratory has a long standing interest in understanding the catalytic and regulatory mechanism of the proton pumping vacuolar ATPase (V-ATPase, V1Vo-ATPase), a...
Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy
Project Summary/Abstract Diabetic retinopathy (DR) is the principal cause of blindness among working-age adults in the United States. In individuals with diabetes mellitus, the dur...
Investigating the role of bromodomain-containing proteins in the production of viable spermatozoa and male fertility
Spermatogenesis is a highly unique differentiation process that involves complex mechanisms of gene regulation, particularly at the level of the transcriptional machinery. The comp...
Cytosolic Access and Instability of DNA nanoparticles
PROJECT SUMMARY/ABSTRACT: A number of candidate therapies such as CRISPR-Cas9 and gene silencing require the efficient delivery of functional nucleic acids to the cell cytosol and...
Bottom-Up Assembly of Functional Salivary Gland Tissues
Project Summary Despite advances in treatment strategies, xerostomia (or dry mouth) remains a permanent and devastating side effect of radiotherapy for head and neck cancers, reduc...
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology Preterm birth before 37th gestational week affects 1 of 10 infants and is an enormous...
Cargo Transport by Myosin Va and Kinesin-1 Molecular Motors: In Vitro Model Systems that Build Complexity in 3-Dimensions.
Project Summary/Abstract Intracellular cargo transport, such as lipid-bound insulin granules and presynaptic vesicles that are destined for secretion at the plasma membrane, rely o...
Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy
Project Summary/Abstract Diabetic retinopathy (DR) is the principal cause of blindness among working-age adults in the United States. In individuals with diabetes mellitus, the dur...
Cytosolic Access and Instability of DNA nanoparticles
PROJECT SUMMARY/ABSTRACT: A number of candidate therapies such as CRISPR-Cas9 and gene silencing require the efficient delivery of functional nucleic acids to the cell cytosol and...
A cryo-box for a 200 kV TEM
Project Summary Our laboratory has a long standing interest in understanding the catalytic and regulatory mechanism of the proton pumping vacuolar ATPase (V-ATPase, V1Vo-ATPase), a...
IUCRC Phase I Baylor College of Medicine: Center to Stream Healthcare In Place (C2SHIP)
Chronic health conditions are financially and emotionally costly. Immediate action is needed to shift from current practice, in which frequently the patient is a passive recipient...
IUCRC Phase I USC: Center to Stream Healthcare In Place (C2SHIP)
Chronic health conditions are financially and emotionally costly. Immediate, creative action is needed to provide solutions for managing physical, social and psychological needs th...
Harnessing the Blinking Heterogeneity of Fluorescent Probes: A New Take on Single-Molecule Research
In this project, funded by the Chemical Structure, Dynamics & Mechanism B Program and the Chemical Measurement and Imaging Program of the Chemistry Division, Kristin L. Wusthol...
Spermatogenic gene regulation and infertility
The Cornell Center for Reproductive Genomics (CRG) was founded in 2007 with the goal of leveraging state-of- the-art genomics technologies for understanding the biology of the mamm...
αvβ3-induced epithelial cancer progression via macrophage recruitment
Project Summary/Abstract It has recently become clear that carcinogenesis and cancer progression involves dysregulation of immune cells within the tumor microenvironment. The parti...
Structure and Regulatory Mechanisms of the Vacuolar ATPase
Project Summary Our laboratory has a long standing interest in understanding the catalytic and regulatory mechanism of the proton pumping vacuolar ATPase (V-ATPase, V1Vo-ATPase), a...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Spermatogenic gene regulation and infertility
The Cornell Center for Reproductive Genomics (CRG) was founded in 2007 with the goal of leveraging state-of- the-art genomics technologies for understanding the biology of the mamm...