Results for Environment
40,772 grants found
Showing 34,201 – 34,220 of 40,772 grants for "Environment"
Investigating Cardiac Ion Channels by Novel Methods
Our long-term overall goals are to discover physiologic homeostatic mechanisms underlying regulation of CaV1.2 channels in the heart and to identify novel therapeutic targets for h...
Defining the functional role of astrocyte-derived lactate
Project Summary/Abstract: The overarching goal of this proposal is to understand the functional role of the glycolytic end-product lactate in the nervous system. Astrocytes, the mo...
Adoption of Family-Driven Substance Use Services in the Juvenile Justice System: A Pre-Implementation Assessment
PROJECT SUMMARY/ABSTRACT Less than one-third of justice-involved youth (JIY) with an identified substance use (SU) need initiate treatment services.One of the most prominently cite...
Green and Sustainable in situ Remediation of Heavy Metals Contaminated Soils and Aqueous Systems
Green and Sustainable in situ Remediation of Heavy Metals Contaminated Soils and Aqueous Systems Project Summary: This SBIR phase I project will demonstrate the feasibility of in s...
Collaborative Research: RoL-Rules for Dynamic-Light Environmental Sculpting of Genomes
The problem of getting a clear signal in a noisy environment is a problem that not only humans must resolve but one that all organisms in nature experience. The goal of this resear...
Investigating the biology and therapeutic vulnerabilities of ER+ metastatic breast cancer with activating HER2 mutations
Project Summary/Abstract The candidate, Ms.Utthara Nayar, PhD, is a translational cancer biologist, and currently a Research Fellow in Medicine at Dana-Farber Cancer Institute, Har...
Investigation of the design, structure and mechanism of Mena protein interaction inhibitors
Project Summary/Abstract Cancer metastasis depends on coordinated cytoskeletal processes induced by a characteristic change in expression of specific motility and actin-regulatory...
Bottom-Up Assembly of Functional Salivary Gland Tissues
Project Summary Despite advances in treatment strategies, xerostomia (or dry mouth) remains a permanent and devastating side effect of radiotherapy for head and neck cancers, reduc...
Preventing the Calcium Channel Blocker – Lower Extremity Edema – Loop Diuretic Prescribing Cascade in Older Adults
PROJECT SUMMARY.Prescribing cascades (PCs), in which drug-induced adverse events (AEs) result in additional treatment rather than deprescribing or dose reduction of the offending a...
Spermatogenic gene regulation and infertility
The Cornell Center for Reproductive Genomics (CRG) was founded in 2007 with the goal of leveraging state-of- the-art genomics technologies for understanding the biology of the mamm...
Investigating the role of bromodomain-containing proteins in the production of viable spermatozoa and male fertility
Spermatogenesis is a highly unique differentiation process that involves complex mechanisms of gene regulation, particularly at the level of the transcriptional machinery.The compl...
Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy
Project Summary/Abstract Diabetic retinopathy (DR) is the principal cause of blindness among working-age adults in the United States.In individuals with diabetes mellitus, the dura...
Cargo Transport by Myosin Va and Kinesin-1 Molecular Motors: In Vitro Model Systems that Build Complexity in 3-Dimensions.
Project Summary/Abstract Intracellular cargo transport, such as lipid-bound insulin granules and presynaptic vesicles that are destined for secretion at the plasma membrane, rely o...
Structure and Regulatory Mechanisms of the Vacuolar ATPase
Project Summary Our laboratory has a long standing interest in understanding the catalytic and regulatory mechanism of the proton pumping vacuolar ATPase (V-ATPase, V1Vo-ATPase), a...
Cytosolic Access and Instability of DNA nanoparticles
PROJECT SUMMARY/ABSTRACT: A number of candidate therapies such as CRISPR-Cas9 and gene silencing require the efficient delivery of functional nucleic acids to the cell cytosol and...
Addressing Lumbar Puncture Challenges Using Patch Ultrasound and Augmented Reality
PROJECT SUMMARY Every year, neurologists and emergency personnel perform over 400,000 diagnostic and therapeutic lumbar punctures (LP) to collect cerebrospinal fluid (CSF), a vital...
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology Preterm birth before 37th gestational week affects 1 of 10 infants and is an enormous...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy
Project Summary/Abstract Diabetic retinopathy (DR) is the principal cause of blindness among working-age adults in the United States. In individuals with diabetes mellitus, the dur...