Results for Environment
40,772 grants found
Showing 34,061 – 34,080 of 40,772 grants for "Environment"
Role of miR-6236 in Obesity-Associated Adipose Tissue Dysfunction
PROJECT SUMMARY/ABSTRACT This proposed two-year project stems directly from studies and career development activities related to my current K08 (DK116668), and represents a new res...
A Web-Based Media Parenting Intervention to Prevent Youth Substance Use
Abstract Youth substance use (SU) is associated with many negative developmental outcomes including morbidity and mortality. Initiation of SU typically occurs during adolescence, a...
Revealing Principles of Subcellular RNA Localization by Proximity Labeling
PROJECT SUMMARY The human body comprises of trillion of cells, which are the building blocks of life. Each cell is highly organized, with various constituents within localizing to...
Improving precision in modeling childhood executive function trajectories using psychometrics
Project Summary: Executive functions are high-level supervisory cognitive skills vital for a child’s social and academic success. Their core components include working memory, inhi...
Multimodal Assessment of Cannabinoid Target Engagement in Adults with Obsessive-Compulsive Disorder
PROJECT SUMMARY/ABSTRACT Obsessive-compulsive disorder (OCD) is a disabling illness affecting about 4.2 million Americans,4 and current treatments including serotonin reuptake inhi...
Optimal Medication Dispensing for People Living with HIV with and without Other Chronic Diseases in Zambia: A Mathematical Model
PROJECT SUMMARY In the current era of universal antiretroviral treatment (ART), health systems have the challenge of optimizing care for a growing number of diverse groups of peopl...
Pathogenesis of Heart Failure with Preserved Ejection Fraction in Chronic Kidney Disease
Project Summary Rupal Mehta, MD is an Assistant Professor of Medicine in the Division of Nephrology and Hypertension at the Northwestern University (NU) Feinberg School of Medicine...
Missouri Study to Explore Early Development (SEED) Follow-Up
Project Summary Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience de...
Understanding the role of TWIST1 in colorectal cancer progression and metastasis
Project Summary: Although almost all colorectal cancer (CRC) mortality is due to metastasis, there are currently no drugs to prevent or halt metastasis. A better understanding of t...
Component A: Study to Explore Early Development (SEED) Follow up Studies
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting >1.5% of children in the United States. Individuals with ASD experience deficits in social communicatio...
Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data
Project Summary - SEED Follow-up Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with...
Colorado SEED Component A & Component B
PROJECT SUMMARY Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience de...
Developing Novel Intervention Approaches to Mitigate Cardiovascular Risk among Young African-American Women
PROJECT SUMMARY Hypertension contributes to high rates of morbidity and mortality of other chronic conditions, including cardiovascular disease, obesity, diabetes, and end stage re...
Improving precision in modeling childhood executive function trajectories using psychometrics
Project Summary: Executive functions are high-level supervisory cognitive skills vital for a child’s social and academic success. Their core components include working memory, inhi...
Investigating Network Plasticity Effects of Repetitive Brain Stimulation Following Invasive and Noninvasive Methods in Humans
Project Summary The goal of this Mentored Patient-Oriented Research Career Development Award (K23) application is to support the additional training, mentorship and experience need...
Delineation of the immunobiology of sarcoidosis and characterization of the effects of Janus kinase inhibition
Project Summary The studies and career development activities described in this K08 application are designed to equip Dr. William Damsky, the Principal Investigator, with experienc...
A BRD4-GATA4 module cooperatively regulates mitochondrial bioenergetic homeostasis in the adult heart
PROJECT SUMMARY / ABSTRACT Heart failure (HF) affects millions of people and costs over 40 billion dollars annually in the United States alone. Despite current pharmacotherapeutic...
Pathogenesis of Heart Failure with Preserved Ejection Fraction in Chronic Kidney Disease
Project Summary Rupal Mehta, MD is an Assistant Professor of Medicine in the Division of Nephrology and Hypertension at the Northwestern University (NU) Feinberg School of Medicine...
Revealing Principles of Subcellular RNA Localization by Proximity Labeling
PROJECT SUMMARY The human body comprises of trillion of cells, which are the building blocks of life. Each cell is highly organized, with various constituents within localizing to...
Regulation of hemoglobin production in normal and disease states
PROJECT SUMMARY / ABSTRACT Reversing the developmental switch from fetal (HbF) to adult hemoglobin is an important therapeutic approach in sickle cell disease (SCD). HbF expression...