Results for Environment
40,772 grants found
Showing 33,821 – 33,840 of 40,772 grants for "Environment"
CNS Core: Small: Integrating Real-Time Learning and Control for Large and Dynamic Networked Computer Systems
Large computer and network systems (such as data centers) are the workhorses driving our information society. However, they are also increasingly difficult to control and operate d...
Machine learning approaches to predict Acetylcholinesterase inhibition
Summary Acetylcholine (Ach) is a neurotransmitter at neuromuscular junctions and synapses in the autonomic and central nervous systems. It also functions as a signaling molecule in...
LAAZ-NPH Clinical Center
PROJECT SUMMARY Nutrition is at the epicenter of human health and disease. However, our current “one size fits all” approach to clinical nutrition is failing a large segment of the...
Integrated analyses of the epigenome to understand the molecular basis of hematopoietic malignancies
PROJECT SUMMARY Research Plan: An impaired hematopoietic differentiation process underlies bone marrow malignancies like leukemia, but we still lack the mechanistic understanding o...
Mechanism of functional modulation of glutamate receptors by their auxiliary subunits
PROJECT SUMMARY The AMPA type ionotropic glutamate receptors (AMPARs) are ligand gated ion channels activated by the neu- rotransmitter glutamate. They mediate the majority of exci...
Uncovering Epigenetic and Transcriptional Drivers of Neuroendocrine Plasticity at Single-Cell Level in Patients with Small Cell Lung Cancer Transformation
PROJECT SUMMARY/ABSTRACT Research: In lung adenocarcinoma (LUAD), neuroendocrine (NE) transformation to small cell lung cancer (SCLC) is associated with metastasis and resistance t...
Understanding longitudinal microbiome change in relation to immunologic outcomes in pediatric SCT recipients.
PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award proposal will provide didactic and experiential training, expert mentorship, and an except...
Investigating the Role of LRRK2 Hyperactivity in Autophagic and Synaptic Deficits
PROJECT SUMMARY Parkinson?s disease (PD) is the second-most prevalent neurodegenerative disease and the fastest- growing.PD increases in both prevalence and severity with age, and...
Effects of geospatial factors and health worker characteristics on child health: implications for interventions in low-resource settings
The career goal of the investigator is to become an independent epidemiologist at an academic institution and utilize a multidisciplinary framework to research and design intervent...
Integrated analyses of the epigenome to understand the molecular basis of hematopoietic malignancies
PROJECT SUMMARY Research Plan: An impaired hematopoietic differentiation process underlies bone marrow malignancies like leukemia, but we still lack the mechanistic understanding o...
Identifying neurophysiological mechanisms of susceptibility to estradiol fluctuation and irritability symptoms in the menopause transition: An experimental approach
PROJECT SUMMARY The emergence of irritability, not depressed mood, is the primary source of distress and impairment for perimenopausal women. Irritability, the predisposition to ex...
LAAZ-NPH Clinical Center
PROJECT SUMMARY Nutrition is at the epicenter of human health and disease. However, our current “one size fits all” approach to clinical nutrition is failing a large segment of the...
The Louisiana Clinical Center of Nutrition for Precision Health (LA-NPH)
PROJECT SUMMARY Nutrition is at the epicenter of human health and disease. However, our current “one size fits all” approach to clinical nutrition is failing a large segment of the...
3D Genome Organization and Gene Expression in Drosophila
Project Summary/Abstract Topologically associating domains (TADs) are three-dimensional organizational units that bring distant genetic loci into close proximity with their regulat...
Patient-Centered Outcomes of the First Approved Peanut Allergy Treatment
PROJECT SUMMARY/ABSTRACT Jennifer Dantzer, MD MHS is an allergy and immunology physician-scientist at Johns Hopkins University, with a Master's Degree in Epidemiology. This K2...
Patient-Centered Outcomes of the First Approved Peanut Allergy Treatment
PROJECT SUMMARY/ABSTRACT Jennifer Dantzer, MD MHS is an allergy and immunology physician-scientist at Johns Hopkins University, with a Master's Degree in Epidemiology. This K2...
Shu complex and RAD52 function in DNA damage recognition and subsequent repair
PROJECT SUMMARY/ABSTRACT Alkylating agents in our environment from tobacco, pesticides, and produced during drinking water purification cause DNA lesions. These DNA lesions can cau...
Understanding the dynamics of cochlear amplification
PROJECT SUMMARY The cochlea acts as a nonlinear amplifier that boosts mechanical sensitivity and frequency tuning at low but not high stimulus levels. Although cochlear responses t...
Prediction of outcomes for deep brain stimulation using multimodal MRI
PROJECT SUMMARY/ABSTRACT Parkinson disease (PD) is a common and growing source of disability worldwide, and adjunctive surgical treatments are often necessary to optimize treatment...
Elucidating the role of RNA oxidation on amyotrophic lateral sclerosis onset and progression
PROJECT SUMMARY A growing body of evidence implicates oxidative stress in Amyotrophic Lateral Sclerosis (ALS). Nevertheless, it is currently unknow if it is a cause, a by-product o...