Results for Environment
40,772 grants found
Showing 33,761 – 33,780 of 40,772 grants for "Environment"
Administrative Core
Abstract The Administrative Core will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, B...
Cancer Immunotherapy Winter School (CIWS)
4.0 PROJECT SUMMARY/ABSTRACT Established in 1984, the Society for Immunotherapy of Cancer (SITC) is the world’s leading member-driven organization specifically dedicated to improvi...
Behavioral and Momentary Assessment of Fear-based Mechanisms underlying Remission in Weight-restored Anorexia Nervosa
Project Summary/Abstract Anorexia nervosa (AN) is a psychiatric illness characterized by low weight, extreme food restriction, intense fear of weight gain, and disturbance in body...
Deciphering the germline-specific mechanisms regulating piRNA gene expression from large genomic domains
Project Summary/Abstract The Piwi-interacting RNA (piRNA) pathway is a conserved small RNA pathway that protects germ cells from consequences arising from active foreign genetic el...
The role of PLIN5 deficiency in podocyte lipotoxicity and progression of Alport Syndrome
PROJECT SUMMARY/ABSTRACT Alport Syndrome (AS) is a hereditary disease caused by mutations in collagen type IV, a main component of the glomerular basement membrane (GBM). Podocytes...
Regulation of endothelial cell phosphatidylserine in thrombosis
Project Summary/Abstract A prothrombotic vessel wall is implicated as a major driver of cardiovascular disease, including heart attacks, strokes, and venous thromboembolism. Despit...
TRPC6 inhibition therapy to rescue cardiac muscle dysfunction in muscular dystrophy
Project Summary This proposal tests the efficacy and mechanisms by which a recently developed, bioavailable, selective small- molecule inhibitor of Transient Receptor Potential Can...
Impact of membrane composition on cholecystokinin receptor structure and function
PROJECT SUMMARY/ABSTRACT Cholecystokinin acts on type 1 receptors (CCK1Rs) present on vagal afferent neurons to regulate satiety, important in prevention and treatment of obesity....
Understanding the predeterminants of transcription factor regulatory activity
PROJECT SUMMARY / ABSTRACT The goal of my research program is to understand how transcription factors (TFs) direct the regulatory programs that underlie cell fate decisions. My lab...
New Methodologies for Connectomics
PROJECT ABSTRACT The nervous systems of animals are comprised of neurons connected by a large number of synapses. The resulting neural networks underlie animal behavior and contrib...
Regulation of endothelial cell phosphatidylserine in thrombosis
Project Summary/Abstract A prothrombotic vessel wall is implicated as a major driver of cardiovascular disease, including heart attacks, strokes, and venous thromboembolism. Despit...
Optimizing Respiratory Culture Practices for Mechanically Ventilated Children
Brief Summary The number of mechanically ventilated children has grown 80-fold since the 1990s and ventilator- associated infections (VAIs) are a leading complication. In the absen...
Impact of membrane composition on cholecystokinin receptor structure and function
PROJECT SUMMARY/ABSTRACT Cholecystokinin acts on type 1 receptors (CCK1Rs) present on vagal afferent neurons to regulate satiety, important in prevention and treatment of obesity....
Behavioral and Neural Substrates of Odor-Guided Navigation in the Human Brain
ABSTRACT Sensory systems have evolved to help meet the behavioral needs of organisms to ensure survival. Across the animal kingdom, two sensory functions are paramount: first, to i...
TRPC6 inhibition therapy to rescue cardiac muscle dysfunction in muscular dystrophy
Project Summary This proposal tests the efficacy and mechanisms by which a recently developed, bioavailable, selective small- molecule inhibitor of Transient Receptor Potential Can...
The role of PLIN5 deficiency in podocyte lipotoxicity and progression of Alport Syndrome
PROJECT SUMMARY/ABSTRACT Alport Syndrome (AS) is a hereditary disease caused by mutations in collagen type IV, a main component of the glomerular basement membrane (GBM). Podocytes...
Mixed methods research to increase engagement and smoking abstinence among African Americans enrolled in Quitline text messaging services
Project Summary/Abstract Cigarettes are used by over 34 million U.S. adults and cause more than 480,000 deaths annually due to smoking and smoke exposure. Despite smoking at simila...
Defining Host-pathogen Interactions in CAUTI to Guide Novel Drug Development
PPROJECT ABSTRACT More than 30 million urinary catheters (UCs) are placed every year in the US, making them the most commonly used indwelling medical device. While short-term UC us...
Collaborative Research: Leveraging Fluid-Structure Interactions for Efficient Control in Geophysical Flows
Microvehicles provide a low-cost platform for a variety of robotics and automation applications. Their excellent maneuverability, agility, and ability to operate in truly three-dim...
Large Baseline Quantum-Enhanced Imaging Networks
Imaging and parameter estimation underpin most of modern science, and the development of improved imaging techniques will have an extremely broad impact, scientifically and cultura...