Results for Environment
40,772 grants found
Showing 33,661 – 33,680 of 40,772 grants for "Environment"
Effects of GLP-1 Receptor Agonists on Airway Inflammation and Platelet Activation in Asthma
PROJECT SUMMARY/ABSTRACT Despite the high prevalence of metabolic dysregulation among patients with asthma, precise mechanisms driving airway inflammation in this population are no...
Validation of a pediatric thrombosis risk assessment model and characterization of bleeding in hospitalized children through the Children's Hospital Acquired Thrombosis (CHAT) Consortium
PROJECT SUMMARY/ABSTRACT Venous thromboembolism (VTE), a serious and life-threatening condition, has increased in incidence for hospitalized pediatric patients by 70-200%. This has...
The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly
PROJECT SUMMARY Cancer continues to be a leading cause of death worldwide. Despite significant efforts devoted towards developing effective treatments, the survival rates remain lo...
Diabetes Promotes Breast Tumor via Glycation-Induced Mechanical Changes in ECM
PROJECT SUMMARY/ABSTRACT Diabetes mellitus is a complex disease associated with hyperglycemia. A growing body of epidemiological evidence supports that patients with comorbidity of...
Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease
Project Summary/Abstract Intestinal immune responses are linked to the trillions of microorganisms that colonize the gastrointestinal tract. Thus, inter-individual variations in th...
Fibrotic extracellular matrix: uncovering its role in breast cancer genome stability and metabolic plasticity
PROJECT ABSTRACT The candidate, Dr. Elizabeth Moore, seeks the proposed Mentored Research Scientist Development Award (K01) to acquire the necessary training and experience to beco...
Functional deficits in neurovascular coupling in Alzheimer's disease
PROJECT SUMMARY Alzheimer’s disease (AD) is a major public health burden in the United states with a death toll that continues to increase steeply. While cerebral blood flow (CBF)...
Neurohumoral Interactions Coordinating Mammalian Cardiomyocyte Size and Proliferation
Project Summary Heart failure after ischemic injury remains a leading cause of death in the United States due to the inability of adult humans to replace lost cardiac muscle after...
Defining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo
Project Summary/Abstract Candidate Goals and Mission Relevance: The applicant’s broad, long-term objective is to investigate how high- (circuit/behavioral) and low- (subcellular/mo...
Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAA
PROJECT SUMMARY Dysregulation of innate immunity is thought to be a significant contributor to Alzheimer’s disease (AD) pathogenesis. We have focused on harnessing innate immunity...
Neurohumoral Interactions Coordinating Mammalian Cardiomyocyte Size and Proliferation
Project Summary Heart failure after ischemic injury remains a leading cause of death in the United States due to the inability of adult humans to replace lost cardiac muscle after...
Neurohumoral Interactions Coordinating Mammalian Cardiomyocyte Size and Proliferation
Project Summary Heart failure after ischemic injury remains a leading cause of death in the United States due to the inability of adult humans to replace lost cardiac muscle after...
Fibrotic extracellular matrix: uncovering its role in breast cancer genome stability and metabolic plasticity
PROJECT ABSTRACT The candidate, Dr. Elizabeth Moore, seeks the proposed Mentored Research Scientist Development Award (K01) to acquire the necessary training and experience to beco...
Functional deficits in neurovascular coupling in Alzheimer's disease
PROJECT SUMMARY Alzheimer’s disease (AD) is a major public health burden in the United states with a death toll that continues to increase steeply. While cerebral blood flow (CBF)...
Health and economic impact analysis of a reduced nicotine cigarette policy on vulnerable populations
PROJECT SUMMARY/ABSTRACT The Food and Drug Administration (FDA) is considering a regulation that would reduce nicotine content in cigarettes to non-addictive levels. This could hav...
IMPAKT Study: Imaging Modalities in Pediatric Assessments of Kidney Transplants
PROJECT SUMMARY/ ABSTRACT The overarching objectives of this proposal are to investigate whether novel quantitative MRI and ultrasound imaging parameters can reliably detect kidney...
Regulation of lupus pathogenesis through modulation of thymic development of pathobiont-specific T cells
PROJECT SUMMARY/ABSTRACT CANDIDATE: I am a postdoctoral research associate in the laboratory of Dr. Gretchen E. Diehl in the Immunology Program at Memorial Sloan-Kettering Cancer C...
Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAA
PROJECT SUMMARY Dysregulation of innate immunity is thought to be a significant contributor to Alzheimer’s disease (AD) pathogenesis. We have focused on harnessing innate immunity...
A Multi-Method Investigation of Cannabis Messaging: Characterizing Source, Content, and Associations with Cannabis Consumption
With the majority of US states having adopted legislation to medically and/or recreationally legalize cannabis, public perception of the drug is now overwhelmingly favorable. Incre...
Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
PROJECT SUMMARY/ABSTRACT Alcohol- (ALD) and non-alcoholic fatty (NAFLD) liver disease are the two leading etiologies of liver disease, accounting for more than 50% of liver-related...