Results for Environment
40,772 grants found
Showing 33,621 – 33,640 of 40,772 grants for "Environment"
The gene regulatory landscape of healthy and failed repair proximal tubule subpopulations in kidney disease
Chronic kidney disease (CKD) has an immense burden on healthcare, with a prevalence of 37 million in the American population. Untreated CKD leads to fibrosis and declining renal fu...
Systematic characterization of cancer variants using single-cell functional genomics
PROJECT SUMMARY/ABSTRACT Cancer is a genetic disease, and the set of mutations in a tumor affects both its behavior and its response to therapies. Large sequencing initiatives have...
Longitudinal Antecedents of Attention Problems in Very Preterm Children: Role of Epigenetics, Executive Function, and Caregiver Psychological Distress
PROJECT SUMMARY/ABSTRACT This K01 proposal will prepare the candidate for an independent research career studying environmental and biological contributors to child neurodevelopmen...
Controlling renal oxidative stress in CKD via targeting FGF23 bioactivity
Project Summary: Rafiou Agoro, PhD is a molecular and cellular biologist whose overarching career goal is to identify promising therapeutic targets relevant for the prevention/trea...
Evaluating the Implementation of High Intensity Home-Based Rehabilitation Following Stroke
Project Summary Stroke is a highly prevalent condition that contributes to significant deficits in functional mobility, particularly in older adults. To address these deficits, pos...
Accelerated evolution of biological RNAs
Project Summary: RNA is capable of diverse biological functions based on its ability to adopt well-defined structures. RNA also can serve as a genetic material that can be synthesi...
Momentary Geospatial, Psychological, and Behavioral Risk for Substance Use in Young Adults Under Criminal Justice Supervision
Project Summary/Abstract This K01 Mentored Research Scientist Development Award will facilitate my long-term career goal of establishing an independently-funded, interdisciplinary...
Evaluating the Implementation of High Intensity Home-Based Rehabilitation Following Stroke
Project Summary Stroke is a highly prevalent condition that contributes to significant deficits in functional mobility, particularly in older adults. To address these deficits, pos...
Prevention of Neonatal Sepsis by Therapeutic Targeting of MDSCs
ABSTRACT Neonatal sepsis results in more than 3 million deaths per annum worldwide and the highest risk of mortality occurs in preterm infants (≤37 weeks). This increased vulnerabi...
Longitudinal Antecedents of Attention Problems in Very Preterm Children: Role of Epigenetics, Executive Function, and Caregiver Psychological Distress
PROJECT SUMMARY/ABSTRACT This K01 proposal will prepare the candidate for an independent research career studying environmental and biological contributors to child neurodevelopmen...
The gene regulatory landscape of healthy and failed repair proximal tubule subpopulations in kidney disease
Chronic kidney disease (CKD) has an immense burden on healthcare, with a prevalence of 37 million in the American population. Untreated CKD leads to fibrosis and declining renal fu...
The Short Course on the Application of Machine Learning for Automated Quantification of Behavior
PROJECT SUMMARY/ABSTRACT Elucidating the mechanism and function of neural encodings and circuit dynamics has been a major challenge in neuroscience and behavioral analyses. However...
Trans-megakaryocyte migration as neutrophil amplifier
Project summary / abstract This K01 award is to provide Dr. Pierre Cunin with the advanced research training, protected time, and mentoring needed to become an independent investig...
The Symmetry-HF Study: Symptom Dynamics and Clinical Biomarkers of Heart Failure in Older Adult Care Dyads After Heart Failure Hospitalization
PROJECT SUMMARY Heart failure (HF) is a devastating public health issue for America's aging population. It is the primary reason for hospital admission for older adults, and H...
Insomnia Treatment and Cardiometabolic Health in Older Adults with Posttraumatic Stress Disorder
Project Summary/Abstract Monica Kelly, PhD is an Adjunct Assistant Professor at the David Geffen School of Medicine at UCLA. She is fully committed to becoming an independently fun...
Evaluating the Implementation of High Intensity Home-Based Rehabilitation Following Stroke
Project Summary Stroke is a highly prevalent condition that contributes to significant deficits in functional mobility, particularly in older adults. To address these deficits, pos...
The impact of vaping aerosol exposure on innate pulmonary defense mechanisms in nonhuman primates
PROJECT SUMMARY Vaping is a serious public health concern that was associated with outbreaks of hospitalizations and deaths in 2019. These outbreaks of electronic vaping associated...
U-RISE at PVAMU
URISE at PVAMU PI/PD: Regisford The increasing need for a well-trained STEM workforce, made more poignant during this COVID-19 pandemic, also requires a diverse population to meet...
Therapeutic potential of FANCM for BRCA1-linked cancer
Project Summary/Abstract Breast and ovarian cancer are among the most common cancers in women worldwide.PARP inhibitors have shown potential for the treatment of BRCA-linked cancer...
Neurocognitive Impairments Resulting from Adolescent Prescription Opioid Use Disorder: Longitudinal Impact, Neural Mechanisms, and Comorbidities
PROJECT SUMMARY/ABSTRACT The goals of the proposed K99 career training plan include: 1) gaining expertise and research experience in substance use disorders (SUD), addictive proces...