Results for Environment
40,772 grants found
Showing 33,401 – 33,420 of 40,772 grants for "Environment"
Prevention of Crohns Disease in High-Risk Individuals
PROJECT SUMMARY/ABSTRACT Crohn’s disease (CD) is a chronic, disabling inflammatory bowel disease (IBD) associated with enormous social and economic impact, decreased quality of lif...
Targeting Pancreatic Cancer Senescence with ImmunoPET
Project Summary Pancreatic cancer is the fourth-most lethal cancer across both sexes, with five-year overall survival of all stages at 12%. In patients diagnosed with pancreatic ca...
Development and characterization of human iPSC-derived neutrophil therapies against pathogenic Aspergilli
Project Summary Over 300,000 new global cases of invasive pulmonary aspergillosis (IPA) are reported each year, with a mortality rate as high as 90%. Therefore, the development of...
A community-led intervention (DAiLY) promoting a heart-healthy diet and active lifestyle: The Yup'ik way
Project Summary/Abstract Heart disease is the leading cause of death for Alaska Native men and the second leading cause of death (after cancer) among women and Alaska Native people...
Unraveling the neural mechanism underlying context-dependent decision making
PROJECT SUMMARY Humans live in a complex and dynamic environment. In our daily lives, many decisions depend on contextual information. For example, when drivers enter a two-way str...
Upstream Requirements for the Regulation of Mitochondrial Bioenergetics by the Mitochondrial Acyl Carrier Protein
PROJECT SUMMARY Recent advances in cell biology have implicated metabolism in diseases ranging from cancer to heart failure. The cellular hubs of metabolism, mitochondria, are ofte...
A metabolomics-based laboratory developed test to better predict and monitor progression of type 1 diabetes
Abstract Type I diabetes (T1D) is an autoimmune disorder in which the host’s T cells attack the insulin-producing β-cells in the pancreatic islet of Langerhans. The onset of sympto...
Reducing Lung Cancer Risk among Appalachian Women Using Community‐Engaged Intervention Research
PROJECT SUMMARY Appalachian women are at high risk for lung cancer. Lung cancer is the leading cause of cancer-related death for women in the US, including the Appalachian region....
Trait-shift induced interaction modification: How individual variation affects ecosystem stability
Individual organisms of the same species can exhibit substantial variation in traits that are important for their interaction with the environment and other species. The distributi...
CAREER: Heterogeneous Secure Computation Framework for Large-scale Data Processing
User-generated data is collected widely on a large scale due to its huge value. Large-scale data collection has significant privacy concerns due to the growing data breaches. Diffe...
2024 Colloidal Semiconductor Nanocrystals Gordon Research Conference and Gordon Research Seminar
Non-Technical SummaryThe 2024 Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) on Colloidal Semiconductor Nanocrystals will take place in early July 2024. These c...
CAREER: Designing and Probing Emergent Phases with Tunable Magnons in Graphene
Non-technical abstractMagnons are quantum mechanical, wave-like objects in magnetic materials that display fundamentally different characteristics than electrons. Harnessing magnon...
Synthesis and design of macrocyclic collagen mimetic peptides for targeting the cancer-implicated DDR2 kinase
Project Summary / Abstract Collagen lays the foundation of bodily tissues, serving to strengthen, connect, and signal from the micro to the macro scale. The importance of collagen...
Harnessing Magnonic Nonreciprocity Through Dissipation Engineering
Energy dissipation resulting from the interaction of a system with its environment has been traditionally viewed solely as a foe that limits signal lifetimes. However, the advent o...
Rare Airway Cell Function in Post-Viral Chronic Inflammation
PROJECT SUMMARY The airway epithelium serves as a barrier between the aerosol environment and the underlying submucosa. Inhaled air often carries noxious agents and pathogens that...
Adenoviral manipulation of arginine methylation
Project Summary: As obligate intracellular pathogens, viruses must hijack cellular machinery to facilitate productive infection. For DNA viruses that depend on host RNA processing...
An investigation into how hepatitis C status affects fibrosis stage and progression among Alaska Native people with non-alcoholic fatty liver disease
PROJECT SUMMARY/ABSTRACT – Research Project 1: “An investigation into how hepatitis C status affects fibrosis stage and progression among Alaska Native people with non-alcoholic fa...
Glutamine Starvation as a Means to Enhance Antibiotic Efficacy against M. tuberculosis
Project Summary Mycobacterium tuberculosis (Mtb) is a public health threat responsible for nearly 2 million deaths annually. While an efficacious chemotherapeutic regimen exists, i...
Toward unshielded MRI for improved safety and access
PROJECT SUMMARY/ABSTRACT Magnetic resonance imaging (MRI) is a valuable non-invasive imaging technology, but it is expensive and out of reach for many centers, especially those in...
Function of reactive astrocytes in aging and neurodegenerative disease
ABSTRACT/PROJECT SUMMARY Reactive astrocytes (RAs) are a feature of normal aging and neurodegeneration. RAs drastically change their morphology and gene expression, notably increas...